EPS15L1 and FCHO2

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (pull down, affinity chromatography technology)

		EPS15L1	FCHO2
Name		epidermal growth factor receptor pathway substrate 15 like 1	FCH and mu domain containing endocytic adaptor 2
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit Membrane Clathrin Coat Of Coated Pit Presynapse	Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit Membrane Clathrin-coated Vesicle Synapse Presynapse
	Molecular Function	Calcium Ion Binding Protein Binding Protein-macromolecule Adaptor Activity Cadherin Binding Metal Ion Binding	Phosphatidylserine Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol Binding Identical Protein Binding
	Biological Process	Endocytosis Endosomal Transport Synaptic Vesicle Endocytosis	Endocytosis Membrane Invagination Clathrin Coat Assembly Synaptic Vesicle Endocytosis Clathrin-dependent Endocytosis Protein Localization To Plasma Membrane
Pathways		EGFR downregulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
GWAS		Basophil count ( 32888494 ) Body size at age 10 ( 32376654 ) Eosinophil count ( 32888494 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 32888494 ) Lymphocyte count ( 32888494 27863252 29403010 ) Lymphocyte percentage of white cells ( 32888494 27863252 ) Monocyte percentage of white cells ( 32888494 27863252 ) Multiple sclerosis ( 22190364 31604244 24076602 ) Neutrophil percentage of granulocytes ( 27863252 ) Neutrophil percentage of white cells ( 27863252 32888494 ) White blood cell count ( 27863252 21738480 32888494 ) White matter integrity ( 23218918 )	Albumin-globulin ratio ( 29403010 ) Aspartate aminotransferase levels ( 33547301 33339817 29403010 ) Discordance in emotional problems in monozygotic twins ( 27043157 ) Eyebrow thickness ( 26926045 ) Factor VIII levels ( 30586737 ) Heel bone mineral density ( 30598549 ) Immunoglobulin measurement (zinc sulfate turbidity test) ( 29403010 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Mean corpuscular hemoglobin concentration ( 32888494 ) Mean platelet volume ( 32888494 ) Monobrow thickness ( 26926045 ) Non-albumin protein levels ( 29403010 ) Red cell distribution width ( 32888494 27863252 ) Serum albumin levels ( 29403010 ) Small cell lung carcinoma ( 28604730 ) vWF levels ( 30586737 ) White matter hyperintensity volume ( 33293549 ) White matter hyperintensity volume (adjusted for hypertension) ( 33293549 )
Novel Interactors		None recorded	1 novel interactors: MRPS27
Interacting Genes		13 interacting genes: ABL1 AGFG1 AGFG2 EPN1 FCHO1 FCHO2 GNG5 LRRC7 SIM2 STON2 TRAPPC2 TRAPPC2B UBC	6 interacting genes: DAB2 EPS15 EPS15L1 ITSN1 RHOU UBC
Entrez ID		58513	115548
HPRD ID		09445	13319
Ensembl ID		ENSG00000127527	ENSG00000157107
Uniprot IDs		A0AAQ5BI61 Q9UBC2	Q0JRZ9
PDB IDs		Not available	2V0O 7OG1 7OHO 7OHZ 7OI5 7OIQ 7OIT
GO Terms Enriched among Interactors		Vesicle-mediated Transport Clathrin-dependent Endocytosis Endocytosis Spermatid Nucleus Differentiation Clathrin-coated Pit TRAPPII Protein Complex TRAPPIII Protein Complex Establishment Of Localization In Cell Import Into Cell TRAPP Complex Vesicle Organization Clathrin Coat Assembly COPII Vesicle Coating Acrosome Assembly Vesicle Tethering Receptor-mediated Endocytosis Vesicle Coating Synaptic Vesicle Endocytosis Presynaptic Endocytosis Protein Localization To Cytoplasmic Microtubule Plus-end Cellular Component Assembly Secretory Granule Organization Transitional One Stage B Cell Differentiation Podocyte Apoptotic Process DN4 Thymocyte Differentiation Phospholipase C-inhibiting G Protein-coupled Receptor Signaling Pathway Protein-containing Complex Assembly Cytoplasm Intermediate Filament Organization Endoplasmic Reticulum-Golgi Intermediate Compartment Clathrin-coated Vesicle Nicotinate-nucleotide Adenylyltransferase Activity Protein Localization To Microtubule Plus-end Intermediate Filament Cytoskeleton Organization Nucleus Organization Intermediate Filament-based Process Vesicle-mediated Transport In Synapse Protein-containing Complex Organization Microspike Assembly B-1 B Cell Homeostasis T Cell Receptor Signaling Pathway Positive Regulation Of Establishment Of T Cell Polarity Neuropilin Signaling Pathway	Clathrin-coated Pit Endocytosis Protein-macromolecule Adaptor Activity Import Into Cell Clathrin Coat Of Coated Pit Postsynaptic Endocytic Zone Vesicle-mediated Transport In Synapse Clathrin Coat Assembly Vesicle-mediated Transport Receptor-mediated Endocytosis Endosomal Transport Synaptic Vesicle Endocytosis Presynaptic Endocytosis Clathrin-coated Vesicle Leading Edge Cell Differentiation Clathrin-dependent Synaptic Vesicle Endocytosis Positive Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of Aldosterone Biosynthetic Process Positive Regulation Of Aldosterone Secretion Calcium Ion Binding Positive Regulation Of Hormone Secretion Positive Regulation Of Caveolin-mediated Endocytosis Positive Regulation Of Endocytosis Plasma Membrane Positive Regulation Of Steroid Hormone Biosynthetic Process Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Hormone Biosynthetic Process Regulation Of Aldosterone Biosynthetic Process Postsynaptic Neurotransmitter Receptor Internalization Ubiquitin-dependent Endocytosis Guanyl-nucleotide Exchange Factor Activity Regulation Of Caveolin-mediated Endocytosis Positive Regulation Of Growth Hormone Secretion Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Focal Adhesion Disassembly Postsynaptic Actin Cytoskeleton Regulation Of Protein Localization AP-2 Adaptor Complex Regulation Of Hormone Secretion Cytosol Receptor-mediated Endocytosis Of Virus By Host Cell Positive Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Secretion By Cell Golgi To Endosome Transport Positive Regulation Of Receptor Recycling Endocytosis Involved In Viral Entry Into Host Cell Regulation Of Growth Hormone Secretion Regulation Of Modification Of Postsynaptic Structure