EPS15L1 and AGFG2

Number of citations: 48 (PubMedID 9303539)
Data Source: BioGRID (genetic interference), HPRD (in vitro)

		EPS15L1	AGFG2
Name		epidermal growth factor receptor pathway substrate 15 like 1	ArfGAP with FG repeats 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit Membrane Clathrin Coat Of Coated Pit Presynapse	Cytoplasm Membrane Cytoplasmic Vesicle
	Molecular Function	Calcium Ion Binding Protein Binding Protein-macromolecule Adaptor Activity Cadherin Binding Metal Ion Binding	GTPase Activator Activity Zinc Ion Binding Metal Ion Binding
	Biological Process	Endocytosis Endosomal Transport Synaptic Vesicle Endocytosis	Acrosome Assembly Spermatid Nucleus Differentiation Intermediate Filament Organization
Pathways		EGFR downregulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	None
GWAS		Basophil count ( 32888494 ) Body size at age 10 ( 32376654 ) Eosinophil count ( 32888494 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 32888494 ) Lymphocyte count ( 32888494 27863252 29403010 ) Lymphocyte percentage of white cells ( 32888494 27863252 ) Monocyte percentage of white cells ( 32888494 27863252 ) Multiple sclerosis ( 22190364 31604244 24076602 ) Neutrophil percentage of granulocytes ( 27863252 ) Neutrophil percentage of white cells ( 27863252 32888494 ) White blood cell count ( 27863252 21738480 32888494 ) White matter integrity ( 23218918 )	Brain morphology (MOSTest) ( 32665545 ) Hematocrit ( 27863252 ) Subcortical volume (MOSTest) ( 32665545 )
Interacting Genes		13 interacting genes: ABL1 AGFG1 AGFG2 EPN1 FCHO1 FCHO2 GNG5 LRRC7 SIM2 STON2 TRAPPC2 TRAPPC2B UBC	4 interacting genes: APP EPS15 EPS15L1 ITSN1
Entrez ID		58513	3268
HPRD ID		09445	04932
Ensembl ID		ENSG00000127527	ENSG00000106351
Uniprot IDs		A0AAQ5BI61 Q9UBC2	A4D2D6 O95081
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Vesicle-mediated Transport Clathrin-dependent Endocytosis Endocytosis Spermatid Nucleus Differentiation Clathrin-coated Pit TRAPPII Protein Complex TRAPPIII Protein Complex Establishment Of Localization In Cell Import Into Cell TRAPP Complex Vesicle Organization Clathrin Coat Assembly COPII Vesicle Coating Acrosome Assembly Vesicle Tethering Receptor-mediated Endocytosis Vesicle Coating Synaptic Vesicle Endocytosis Presynaptic Endocytosis Protein Localization To Cytoplasmic Microtubule Plus-end Cellular Component Assembly Secretory Granule Organization Transitional One Stage B Cell Differentiation Podocyte Apoptotic Process DN4 Thymocyte Differentiation Phospholipase C-inhibiting G Protein-coupled Receptor Signaling Pathway Protein-containing Complex Assembly Cytoplasm Intermediate Filament Organization Endoplasmic Reticulum-Golgi Intermediate Compartment Clathrin-coated Vesicle Nicotinate-nucleotide Adenylyltransferase Activity Protein Localization To Microtubule Plus-end Intermediate Filament Cytoskeleton Organization Nucleus Organization Intermediate Filament-based Process Vesicle-mediated Transport In Synapse Protein-containing Complex Organization Microspike Assembly B-1 B Cell Homeostasis T Cell Receptor Signaling Pathway Positive Regulation Of Establishment Of T Cell Polarity Neuropilin Signaling Pathway	Clathrin-coated Pit Endocytosis Vesicle-mediated Transport In Synapse Clathrin Coat Of Coated Pit Import Into Cell Postsynaptic Endocytic Zone Protein-macromolecule Adaptor Activity Endosomal Transport Intracellular Transport Vesicle-mediated Transport Synaptic Vesicle Endocytosis Presynaptic Endocytosis Cellular Localization Establishment Of Localization In Cell Calcium Ion Binding Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Endosome Acetylcholine Receptor Activator Activity Recycling Endosome Regulation Of Postsynapse Organization Lipoprotein Particle Positive Regulation Of Protein Import Dendritic Spine Clathrin-dependent Synaptic Vesicle Endocytosis PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Positive Regulation Of Endocytosis Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Synapse Receptor-mediated Endocytosis Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Early Endosome Membrane Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Caveolin-mediated Endocytosis Presynapse Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition