EPS15L1 and EPN1

Number of citations of the paper that reports this interaction (PMID 9723620)
127

Data Source:
HPRD (in vitro)

		EPS15L1	EPN1
Gene Name		epidermal growth factor receptor pathway substrate 15-like 1	epsin 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Plasma Membrane Coated Pit Membrane	Nucleus Cytoplasm Plasma Membrane Coated Pit
	Molecular Function	Calcium Ion Binding Protein Binding	Transcription Factor Binding Lipid Binding
	Biological Process	Endocytosis Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway	In Utero Embryonic Development Endocytosis Epidermal Growth Factor Receptor Signaling Pathway Notch Signaling Pathway Female Pregnancy Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Embryonic Organ Development
Pathways		Signaling by EGFR EGFR downregulation Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer	Signaling by EGFR EGFR downregulation Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer
Drugs
Diseases
GWAS		Multiple sclerosis ( 22190364) White blood cell count ( 21738480) White matter integrity ( 23218918)	Major depressive disorder ( 23377640)
Protein-Protein Interactions		8 interactors: AGFG1 AGFG2 EPN1 GNG5 ITSN1 ITSN2 STON2 TRAPPC2B	20 interactors: AP2A1 AP2A2 CDK1 CLTC CRMP1 DAZAP2 EPS15 EPS15L1 FBXO25 KIAA1377 LAPTM5 MED31 PLEKHB2 REPS2 RNF11 SCNN1A SCNN1B SCNN1G UBC ZBTB16
Entrez ID		58513	29924
HPRD ID		09445	06270
Ensembl ID		ENSG00000127527	ENSG00000063245
Uniprot IDs		Q9UBC2	Q9Y6I3
PDB IDs			1INZ
Enriched GO Terms of Interacting Partners?		Regulation Of Ras GTPase Activity Endocytosis Regulation Of Ras Protein Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Regulation Of GTPase Activity Synaptic Vesicle Endocytosis Synaptic Vesicle Recycling Positive Regulation Of Hydrolase Activity Regulation Of ARF GTPase Activity Regulation Of Signal Transduction Regulation Of ARF Protein Signal Transduction Vesicle-mediated Transport Synaptic Vesicle Transport Synaptic Transmission Positive Regulation Of Catalytic Activity Regulation Of Signaling Regulation Of Intracellular Signal Transduction Establishment Of Vesicle Localization Vesicle Localization Cell-cell Signaling Positive Regulation Of Rho GTPase Activity Regulation Of Rho GTPase Activity Regulation Of Catalytic Activity Establishment Of Organelle Localization Regulation Of Rho Protein Signal Transduction Acrosome Assembly Intermediate Filament Organization Transport Organelle Localization Positive Regulation Of Ras GTPase Activity Regulation Of Cellular Process Spermatid Nucleus Differentiation Positive Regulation Of Metabolic Process	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Sodium Ion Homeostasis Negative Regulation Of Hyaluronan Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Excretion Multicellular Organismal Water Homeostasis Water Homeostasis Sensory Perception Of Taste Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Post-Golgi Vesicle-mediated Transport Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Golgi To Endosome Transport Endocytosis Regulation Of Defense Response To Virus By Virus Axon Guidance Cell Projection Morphogenesis Cell Part Morphogenesis Clathrin-mediated Endocytosis Sodium Ion Transmembrane Transport Endosomal Transport Axonogenesis Axon Development Toll-like Receptor 5 Signaling Pathway Protein Ubiquitination Toll-like Receptor 10 Signaling Pathway Cellular Response To Growth Factor Stimulus Pronuclear Fusion Sodium Ion Transport Cell Morphogenesis Involved In Neuron Differentiation Cell Morphogenesis Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Chemotaxis Response To Growth Factor Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Toll-like Receptor 2 Signaling Pathway Protein Modification By Small Protein Conjugation Golgi Vesicle Transport Toll-like Receptor 9 Signaling Pathway
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