MICALL1 and YWHAB

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		MICALL1	YWHAB
Description		MICAL like 1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
Image
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Late Endosome Trans-Golgi Network Centriole Cytoskeleton Plasma Membrane Adherens Junction Cilium Cytoplasmic Side Of Endosome Membrane Membrane Late Endosome Membrane Cell Projection Recycling Endosome Membrane Ciliary Membrane	Nucleus Cytoplasm Vacuole Vacuolar Membrane Cytosol Focal Adhesion Membrane Transcription Repressor Complex Protein-containing Complex Melanosome Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding Cytoskeletal Anchor Activity Protein-macromolecule Adaptor Activity Small GTPase Binding Identical Protein Binding Cadherin Binding Metal Ion Binding Phosphatidic Acid Binding	Protein Kinase Inhibitor Activity Protein Phosphatase Inhibitor Activity Protein Binding Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Histone Deacetylase Binding Protein-containing Complex Binding Cadherin Binding Phosphoserine Residue Binding Phosphoprotein Binding Protein Sequestering Activity
	Biological Process	Cell Migration Involved In Sprouting Angiogenesis Protein Targeting To Membrane Endocytosis Receptor-mediated Endocytosis Protein Transport Neuron Projection Development Endocytic Recycling Slow Endocytic Recycling Protein Localization To Endosome Cilium Assembly Protein Localization To Cilium Plasma Membrane Tubulation Plasma Membrane Bounded Cell Projection Organization	Protein Targeting Signal Transduction Intracellular Protein Localization Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways			Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane MTOR signalling mTORC1-mediated signalling Frs2-mediated activation Frs2-mediated activation ARMS-mediated activation Signaling by Hippo Rap1 signalling Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA RHO GTPases activate PKNs TP53 Regulates Metabolic Genes RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Regulation of localization of FOXO transcription factors Signaling downstream of RAS mutants Signaling by RAF1 mutants SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs			Copper Phenethyl Isothiocyanate
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Heel bone mineral density ( 30598549) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576) Breakfast cereal skipping frequency ( 31190057) Breakfast skipping ( 31190057) Mean platelet volume ( 32888494)
Interacting Genes		6 interacting genes: RAB13 RAB1A RFFL YWHAB YWHAG ZP3	147 interacting genes: ABL1 ADAM22 AFDN AKAP13 ALS2 APP ATP5F1A BAD BAX BCL2L11 BCR BID BRAF C1QBP CAMK2A CAMK2B CBL CDC25A CDC25B CDC25C CDK11B CDK14 CDKN1B CHAF1A CRTC2 CSNK2A1 DAPK1 DHX15 DYRK1A EDC3 EGFR EPB41 EPB41L1 EPB41L3 ERRFI1 EXO1 FER FILNC1 FRMD6 GAPVD1 GEM H3C1 HDAC5 HES1 HSP90AB1 HSPA1A HSPA1B HSPA5 HSPB1 IGF1R IKBKB ING1 INSR IRS1 IRS2 ITGB1 ITGB4 KANK1 KCNK15 KCNK3 KCNK9 KIAA0930 KIF1C KIF23 KIF5B KLC1 KRT18 LARP1 LYST MAP3K3 MAPK7 MAPT MARK2 MARK4 MDM4 MICALL1 MINK1 MLXIP MPRIP MST1R MTNR1A MTNR1B NCAM2 NEDD4L OSBPL3 PARD3 PARD6B PDCL2 PDE3B PDE4B PI4KB PIK3R2 PIK3R4 PRKCD PRKCG PRKCZ PRPF6 PTPN3 RABGEF1 RACGAP1 RADIL RAF1 RAI14 RALGPS2 RASGRF1 RGS3 RGS7 RIN1 RIOK1 RIPK2 RMDN3 RNPS1 RPS6KA1 SAMSN1 SKP2 SLC4A7 SLC8A1 SLC8A2 SLC8A3 SLC9A1 SNCA SNRNP200 SON SRC SRRM2 SRSF10 SRSF3 STK38 STK38L TESK1 TESK2 TH TJP2 TNFAIP3 TPD52L1 TSC1 TSC2 TUBB UBC UCP2 UCP3 WDR77 WEE1 YWHAE YWHAG ZFP36 ZFP36L1
Entrez ID		85377	7529
HPRD ID		11363	03184
Ensembl ID		ENSG00000100139	ENSG00000166913
Uniprot IDs		A0A7P0T9P2 B0QY86 B0QY91 Q8N3F8	P31946 V9HWD6
PDB IDs		2KSP	2BQ0 2C23 4DNK 5N10 6A5Q 6BYK 6GN0 6GN8 6GNJ 6GNK 6GNN 6HEP 8DP5 8EQ8 8EQH
Enriched GO Terms of Interacting Partners?		Establishment Of Protein Localization Intracellular Protein Localization Protein Sequestering Activity Trans-Golgi Network To Recycling Endosome Transport Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Type IV Hypersensitivity Positive Regulation Of Antral Ovarian Follicle Growth Melanosome Cellular Response To Insulin Stimulus Recycling Endosome Membrane Regulation Of T Cell Mediated Immunity Epithelial Cell Development Positive Regulation Of Immune Response Response To Insulin Protein Localization To Cell Leading Edge Establishment Of Sertoli Cell Barrier Regulation Of TOR Signaling Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Protein Kinase C Inhibitor Activity Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Adaptive Immune Response Positive Regulation Of Acrosomal Vesicle Exocytosis Positive Regulation Of Ovarian Follicle Development Egg Coat Formation Acrosin Binding Negative Regulation Of Binding Of Sperm To Zona Pellucida Structural Constituent Of Egg Coat Egg Coat Regulation Of Type IV Hypersensitivity Regulation Of Acrosomal Vesicle Exocytosis Endosome Cellular Response To Peptide Hormone Stimulus Regulation Of Binding Of Sperm To Zona Pellucida Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of Ovarian Follicle Development Growth Hormone Secretion Insulin-responsive Compartment Protein Targeting Phosphoserine Residue Binding Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Lymphocyte Mediated Immunity Cell Development Regulation Of Adaptive Immune Response Extracellular Exosome Protein Domain Specific Binding Positive Regulation Of Hypersensitivity Virion Assembly Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Acrosome Reaction Regulation Of Immune Response	Kinase Activity Protein Kinase Activity Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Cytosol Protein Serine Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Protein Serine/threonine Kinase Activity Regulation Of Signal Transduction Positive Regulation Of Cell Communication Cytoplasm Protein Phosphorylation ATP Binding Positive Regulation Of Signaling Negative Regulation Of Signaling Negative Regulation Of Cell Communication Phosphorylation Negative Regulation Of Signal Transduction Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Nucleotide Binding Positive Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Programmed Cell Death Regulation Of Protein Modification Process Signal Transduction Cellular Response To Oxygen-containing Compound Protein Tyrosine Kinase Activity Response To Stress Cellular Response To Stress Regulation Of Cell Cycle Regulation Of Membrane Potential Intracellular Signaling Cassette Cellular Response To Hormone Stimulus Cadherin Binding Regulation Of Protein-containing Complex Assembly Regulation Of Phosphorus Metabolic Process Cellular Response To Insulin Stimulus Regulation Of Protein Phosphorylation Regulation Of Biological Quality Plasma Membrane Response To Insulin Positive Regulation Of Catabolic Process Phosphate-containing Compound Metabolic Process Cellular Response To Peptide Hormone Stimulus Regulation Of Phosphorylation
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