MICALL1 and RFFL

Number of citations of the paper that reports this interaction (PubMedID 30659120)
0

Data Source:
BioGRID (enzymatic study)

		MICALL1	RFFL
Description		MICAL like 1	ring finger and FYVE like domain containing E3 ubiquitin protein ligase
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GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Late Endosome Trans-Golgi Network Centriole Cytoskeleton Plasma Membrane Adherens Junction Cilium Cytoplasmic Side Of Endosome Membrane Membrane Late Endosome Membrane Cell Projection Recycling Endosome Membrane Ciliary Membrane	Golgi Membrane Nucleoplasm Cytoplasm Lysosome Endosome Cytosol Plasma Membrane Endosome Membrane Membrane Cytoplasmic Vesicle Recycling Endosome Membrane
	Molecular Function	Protein Binding Cytoskeletal Anchor Activity Protein-macromolecule Adaptor Activity Small GTPase Binding Identical Protein Binding Cadherin Binding Metal Ion Binding Phosphatidic Acid Binding	Protease Binding P53 Binding Protein Binding Zinc Ion Binding Transferase Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Cell Migration Involved In Sprouting Angiogenesis Protein Targeting To Membrane Endocytosis Receptor-mediated Endocytosis Protein Transport Neuron Projection Development Endocytic Recycling Slow Endocytic Recycling Protein Localization To Endosome Cilium Assembly Protein Localization To Cilium Plasma Membrane Tubulation Plasma Membrane Bounded Cell Projection Organization	Ubiquitin-dependent Protein Catabolic Process Intracellular Protein Transport Apoptotic Process Regulation Of Fibroblast Migration Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Ubiquitination Regulation Of TOR Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways			Regulation of TP53 Degradation
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Heel bone mineral density ( 30598549) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494)	Acute post-radiotherapy pain in breast cancer ( 31196165) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Night sleep phenotypes ( 27126917) QT interval ( 19305408)
Interacting Genes		6 interacting genes: RAB13 RAB1A RFFL YWHAB YWHAG ZP3	24 interacting genes: ATXN3 ATXN3L CFTR EHD1 ESPL1 MICALL1 OPTN OTUB1 OTUB2 PRKN RAB11FIP1 SFN STAM STUB1 UBE2D1 UBE2D2 UBE2D3 UBE2G2 UBE2N UBE2V2 UCHL5 USP28 USP5 USP7
Entrez ID		85377	117584
HPRD ID		11363	11489
Ensembl ID		ENSG00000100139	ENSG00000092871
Uniprot IDs		A0A7P0T9P2 B0QY86 B0QY91 Q8N3F8	Q8WZ73
PDB IDs		2KSP	1Y02
Enriched GO Terms of Interacting Partners?		Establishment Of Protein Localization Intracellular Protein Localization Protein Sequestering Activity Trans-Golgi Network To Recycling Endosome Transport Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Type IV Hypersensitivity Positive Regulation Of Antral Ovarian Follicle Growth Melanosome Cellular Response To Insulin Stimulus Recycling Endosome Membrane Regulation Of T Cell Mediated Immunity Epithelial Cell Development Positive Regulation Of Immune Response Response To Insulin Protein Localization To Cell Leading Edge Establishment Of Sertoli Cell Barrier Regulation Of TOR Signaling Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Protein Kinase C Inhibitor Activity Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Adaptive Immune Response Positive Regulation Of Acrosomal Vesicle Exocytosis Positive Regulation Of Ovarian Follicle Development Egg Coat Formation Acrosin Binding Negative Regulation Of Binding Of Sperm To Zona Pellucida Structural Constituent Of Egg Coat Egg Coat Regulation Of Type IV Hypersensitivity Regulation Of Acrosomal Vesicle Exocytosis Endosome Cellular Response To Peptide Hormone Stimulus Regulation Of Binding Of Sperm To Zona Pellucida Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of Ovarian Follicle Development Growth Hormone Secretion Insulin-responsive Compartment Protein Targeting Phosphoserine Residue Binding Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Lymphocyte Mediated Immunity Cell Development Regulation Of Adaptive Immune Response Extracellular Exosome Protein Domain Specific Binding Positive Regulation Of Hypersensitivity Virion Assembly Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Acrosome Reaction Regulation Of Immune Response	Post-translational Protein Modification Protein Deubiquitination Protein Modification By Small Protein Removal Cysteine-type Peptidase Activity Proteolysis Cysteine-type Deubiquitinase Activity Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of TORC1 Signaling Proteolysis Involved In Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Negative Regulation Of TOR Signaling Protein Polyubiquitination Cellular Response To Stress Regulation Of TORC1 Signaling Protein Ubiquitination Ubiquitin Binding Peptidase Activity Positive Regulation Of Protein Polyubiquitination Ubiquitin Conjugating Enzyme Complex Regulation Of Proteasomal Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Metabolic Process DNA Repair TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Deubiquitination Ubiquitin-protein Transferase Activity Catabolic Process DNA Damage Response Regulation Of TOR Signaling Cellular Response To Topologically Incorrect Protein Macromolecule Catabolic Process Regulation Of Protein Polyubiquitination Protein Catabolic Process TOR Signaling Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Protein Ubiquitination DNA Metabolic Process Regulation Of Cellular Response To Stress Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Intracellular Signal Transduction Cytosol Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Post-translational Protein Modification Protein Monoubiquitination
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