MICALL1 and ZP3

Number of citations of the paper that reports this interaction (PMID 19945174)
4

Data Source:
BioGRID (two hybrid)

		MICALL1	ZP3
Gene Name		MICAL-like 1	zona pellucida glycoprotein 3 (sperm receptor)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Early Endosome Late Endosome Trans-Golgi Network Extrinsic Component Of Membrane Late Endosome Membrane Recycling Endosome Membrane	Acrosomal Vesicle Outer Acrosomal Membrane Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Cytoplasm Multivesicular Body Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Membrane Secretory Granule Extracellular Matrix Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Zinc Ion Binding Rab GTPase Binding Identical Protein Binding Phosphatidic Acid Binding	Signal Transducer Activity Manganese Ion Transmembrane Transporter Activity Protein Binding Store-operated Calcium Channel Activity Carbohydrate Binding Acrosin Binding
	Biological Process	Protein Targeting To Membrane Endocytosis Receptor-mediated Endocytosis Neuron Projection Development Slow Endocytic Recycling Protein Localization To Endosome Membrane Tubulation Cellular Response To Nerve Growth Factor Stimulus Retrograde Transport, Endosome To Plasma Membrane	Positive Regulation Of Type IV Hypersensitivity Blastocyst Formation Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Leukocyte Migration Positive Regulation Of Humoral Immune Response Manganese Ion Transport Intracellular Protein Transport Single Fertilization Binding Of Sperm To Zona Pellucida Positive Regulation Of Phosphatidylinositol Biosynthetic Process Multicellular Organism Reproduction Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-4 Production Intracellular Signal Transduction Egg Coat Formation Positive Regulation Of T Cell Proliferation Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Phosphatidylinositol-mediated Signaling Oocyte Development Positive Regulation Of Inflammatory Response Positive Regulation Of Protein Kinase B Signaling Protein Kinase C Signaling Calcium Ion Transmembrane Transport Manganese Ion Transmembrane Transport Positive Regulation Of Calcium Ion Import Positive Regulation Of Acrosome Reaction Negative Regulation Of Binding Of Sperm To Zona Pellucida Positive Regulation Of Acrosomal Vesicle Exocytosis Positive Regulation Of Ovarian Follicle Development Positive Regulation Of Antral Ovarian Follicle Growth
Pathways			Interaction With The Zona Pellucida Fertilization
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: EHD1 RAB1A YWHAB YWHAG ZP3	9 interactors: ACR ENGASE FURIN MICALL1 MRPS16 OR2L13 PCDH17 SPACA3 UBAP2L
Entrez ID		85377	7784
HPRD ID		11363	01690
Ensembl ID		ENSG00000100139	ENSG00000188372
Uniprot IDs		Q8N3F8	P21754
PDB IDs		2KSP
Enriched GO Terms of Interacting Partners?		Intracellular Protein Transport Cellular Protein Localization Protein Transport Establishment Of Protein Localization Intracellular Transport Protein Localization Positive Regulation Of Transport Establishment Of Localization In Cell Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Intracellular Transport Cellular Localization Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cellular Localization Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Regulation Of Intracellular Transport Cell Differentiation Regulation Of Mitochondrion Organization Cell Development Intracellular Signal Transduction Positive Regulation Of Acrosomal Vesicle Exocytosis Positive Regulation Of Ovarian Follicle Development Positive Regulation Of Antral Ovarian Follicle Growth Positive Regulation Of Type IV Hypersensitivity Regulation Of Protein Kinase Activity Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Anatomical Structure Development Interleukin-8 Secretion Cargo Loading Into COPII-coated Vesicle Egg Coat Formation Transport Membrane Organization Positive Regulation Of Endocytic Recycling Regulation Of Ovarian Follicle Development Intrinsic Apoptotic Signaling Pathway Developmental Process Positive Regulation Of Apoptotic Signaling Pathway Protein Complex Assembly Interleukin-8 Production Negative Regulation Of Binding Of Sperm To Zona Pellucida Positive Regulation Of Phosphatidylinositol Biosynthetic Process Cellular Response To Insulin Stimulus Ras Protein Signal Transduction Regulation Of Protein Phosphorylation Regulation Of Endocytic Recycling Negative Regulation Of Protein Dephosphorylation Positive Regulation Of Acrosome Reaction Positive Regulation Of Phospholipid Biosynthetic Process Positive Regulation Of Protein Metabolic Process	Sperm-egg Recognition Cell-cell Recognition Cell Recognition Single Fertilization Fertilization Binding Of Sperm To Zona Pellucida Acrosome Matrix Dispersal Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Slow Endocytic Recycling Nerve Growth Factor Production Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Receptor Catabolic Process Nerve Growth Factor Processing Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Production Cell Wall Macromolecule Catabolic Process Sexual Reproduction Monocyte Activation Protein Localization To Endosome Peptidoglycan Catabolic Process Retrograde Transport, Endosome To Plasma Membrane Viral Protein Processing Positive Regulation Of Macrophage Activation Positive Regulation Of Membrane Protein Ectodomain Proteolysis Peptidyl-glutamic Acid Carboxylation Reproduction
Tagcloud ?			blastocyst build careful cdx2 correct embryo embryogenesis embryos epiblast filmed generates genotyped gives icm individually loxp morula onwards oocyte placenta pluripotent pools segregation specification starts te trophectoderm unambiguously zygotic
Tagcloud (Difference) ?			blastocyst build careful cdx2 correct embryo embryogenesis embryos epiblast filmed generates genotyped gives icm individually loxp morula onwards oocyte placenta pluripotent pools segregation specification starts te trophectoderm unambiguously zygotic
Tagcloud (Intersection) ?