MICALL1 and ZP3

Number of citations of the paper that reports this interaction (PubMedID 19945174)
29

Data Source:
BioGRID (two hybrid)

		MICALL1	ZP3
Description		MICAL like 1	zona pellucida glycoprotein 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Late Endosome Trans-Golgi Network Centriole Cytoskeleton Plasma Membrane Adherens Junction Cilium Cytoplasmic Side Of Endosome Membrane Membrane Late Endosome Membrane Cell Projection Recycling Endosome Membrane Ciliary Membrane	Extracellular Region Extracellular Space Plasma Membrane Membrane Extracellular Matrix Egg Coat
	Molecular Function	Protein Binding Cytoskeletal Anchor Activity Protein-macromolecule Adaptor Activity Small GTPase Binding Identical Protein Binding Cadherin Binding Metal Ion Binding Phosphatidic Acid Binding	Extracellular Matrix Structural Constituent Protein Binding Carbohydrate Binding Acrosin Binding Structural Constituent Of Egg Coat Identical Protein Binding Receptor Ligand Activity
	Biological Process	Cell Migration Involved In Sprouting Angiogenesis Protein Targeting To Membrane Endocytosis Receptor-mediated Endocytosis Protein Transport Neuron Projection Development Endocytic Recycling Slow Endocytic Recycling Protein Localization To Endosome Cilium Assembly Protein Localization To Cilium Plasma Membrane Tubulation Plasma Membrane Bounded Cell Projection Organization	Positive Regulation Of Type IV Hypersensitivity Blastocyst Formation Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Leukocyte Migration Positive Regulation Of Humoral Immune Response Signal Transduction Single Fertilization Binding Of Sperm To Zona Pellucida Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-4 Production Egg Coat Formation Positive Regulation Of T Cell Proliferation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Oocyte Development Positive Regulation Of Inflammatory Response Positive Regulation Of Acrosome Reaction Negative Regulation Of Binding Of Sperm To Zona Pellucida Positive Regulation Of Acrosomal Vesicle Exocytosis Positive Regulation Of Ovarian Follicle Development Positive Regulation Of Antral Ovarian Follicle Growth
Pathways			Interaction With Cumulus Cells And The Zona Pellucida
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Heel bone mineral density ( 30598549) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494)	Parkinson disease and lewy body pathology ( 25663231)
Interacting Genes		6 interacting genes: RAB13 RAB1A RFFL YWHAB YWHAG ZP3	11 interacting genes: ACR CLDN11 ENGASE FURIN MALL MICALL1 MRPS16 OR2L13 PCDH17 SPACA3 UBAP2L
Entrez ID		85377	7784
HPRD ID		11363	01690
Ensembl ID		ENSG00000100139	ENSG00000188372
Uniprot IDs		A0A7P0T9P2 B0QY86 B0QY91 Q8N3F8	P21754
PDB IDs		2KSP
Enriched GO Terms of Interacting Partners?		Establishment Of Protein Localization Intracellular Protein Localization Protein Sequestering Activity Trans-Golgi Network To Recycling Endosome Transport Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Type IV Hypersensitivity Positive Regulation Of Antral Ovarian Follicle Growth Melanosome Cellular Response To Insulin Stimulus Recycling Endosome Membrane Regulation Of T Cell Mediated Immunity Epithelial Cell Development Positive Regulation Of Immune Response Response To Insulin Protein Localization To Cell Leading Edge Establishment Of Sertoli Cell Barrier Regulation Of TOR Signaling Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Protein Kinase C Inhibitor Activity Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Adaptive Immune Response Positive Regulation Of Acrosomal Vesicle Exocytosis Positive Regulation Of Ovarian Follicle Development Egg Coat Formation Acrosin Binding Negative Regulation Of Binding Of Sperm To Zona Pellucida Structural Constituent Of Egg Coat Egg Coat Regulation Of Type IV Hypersensitivity Regulation Of Acrosomal Vesicle Exocytosis Endosome Cellular Response To Peptide Hormone Stimulus Regulation Of Binding Of Sperm To Zona Pellucida Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of Ovarian Follicle Development Growth Hormone Secretion Insulin-responsive Compartment Protein Targeting Phosphoserine Residue Binding Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Lymphocyte Mediated Immunity Cell Development Regulation Of Adaptive Immune Response Extracellular Exosome Protein Domain Specific Binding Positive Regulation Of Hypersensitivity Virion Assembly Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Acrosome Reaction Regulation Of Immune Response	Acrosomal Matrix Sperm-egg Recognition Cell-cell Recognition Cell Recognition Binding Of Sperm To Zona Pellucida Acrosome Matrix Dispersal Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Mannosyl-glycoprotein Endo-beta-N-acetylglucosaminidase Activity Cytoplasmic Side Of Endosome Membrane Amidase Activity Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Slow Endocytic Recycling Axon Ensheathment Negative Regulation Of Receptor Catabolic Process Presynaptic Active Zone Assembly Protease Binding Acrosomal Vesicle Viral Translation Viral Life Cycle Serine-type Peptidase Activity Plasma Membrane Organization Cytokine Precursor Processing Nerve Growth Factor Binding Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Transforming Growth Factor Beta1 Production Regulation Of Synaptic Vesicle Clustering Serine-type Endopeptidase Activity Fucose Binding Positive Regulation Of Stress Granule Assembly Lysozyme Activity
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