RASGRP1 and DGKZ

Number of citations of the paper that reports this interaction (PMID 11257115)
28

Data Source:
HPRD (in vitro, in vivo)

		RASGRP1	DGKZ
Gene Name		RAS guanyl releasing protein 1 (calcium and DAG-regulated)	diacylglycerol kinase, zeta
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Mast Cell Granule	Nucleus Nucleoplasm Cytoplasm Plasma Membrane Lamellipodium
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Lipid Binding	Lipid Kinase Activity NAD+ Kinase Activity Diacylglycerol Kinase Activity Enzyme Inhibitor Activity Protein Binding ATP Binding Protein C-terminus Binding Metal Ion Binding
	Biological Process	Cytokine Production Inflammatory Response To Antigenic Stimulus Signal Transduction Ras Protein Signal Transduction Blood Coagulation Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Differentiation Platelet Activation Secretory Granule Localization Activation Of Rho GTPase Activity Fc-epsilon Receptor Signaling Pathway Mast Cell Degranulation Innate Immune Response Vesicle Transport Along Microtubule	Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Blood Coagulation Phosphorylation Cell Migration Platelet Activation Mitotic G1 DNA Damage Checkpoint Intracellular Signal Transduction Negative Regulation Of Catalytic Activity Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Ras Protein Signal Transduction Lipid Phosphorylation
Pathways		G alpha (q) signalling events Signaling by the B Cell Receptor (BCR) Signaling by GPCR Integrin alphaIIb beta3 signaling Platelet Aggregation (Plug Formation) Effects of PIP2 hydrolysis G alpha (q) signalling events Downstream signaling events of B Cell Receptor (BCR) GPCR downstream signaling FCERI mediated NF-kB activation Rap1 signalling Activation of RAS in B cells Gastrin-CREB signalling pathway via PKC and MAPK Fc epsilon receptor (FCERI) signaling Platelet activation, signaling and aggregation Adaptive Immune System Innate Immune System	G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Platelet activation, signaling and aggregation Effects of PIP2 hydrolysis
Drugs
Diseases
GWAS		Bipolar disorder ( 18711365) Crohn's disease ( 23128233) Type 1 diabetes ( 18840781) Type 1 diabetes autoantibodies ( 21829393) Type 2 diabetes ( 22961080)	Immunoglobulin A ( 20694011)
Protein-Protein Interactions		2 interactors: DGKZ HRAS	18 interactors: DMD HRAS LEPR MAPK6 PLCG1 POLR2M PRKCA RASGRP1 RB1 RBL1 RBL2 SAT1 SNTA1 SNTB1 SNTB2 SNTG1 SNX27 SRC
Entrez ID		10125	8525
HPRD ID		04909	03260
Ensembl ID		ENSG00000172575	ENSG00000149091
Uniprot IDs		B2RA89 F5H514 O95267	B7Z6M3 F6UCU9 Q13574
PDB IDs		4L9M 4L9U
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Checkpoint Negative Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Regulation Of Mitotic Cell Cycle Blood Coagulation Hemostasis Negative Regulation Of Cell Cycle Positive Regulation Of Rac Protein Signal Transduction Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Ruffle Assembly Regulation Of Body Fluid Levels Wound Healing Regulation Of Ras Protein Signal Transduction Mitotic Cell Cycle Process Regulation Of MiRNA Metabolic Process Response To Wounding Regulation Of Small GTPase Mediated Signal Transduction Mitotic Cell Cycle Negative Regulation Of Catalytic Activity Negative Regulation Of Rho GTPase Activity Positive Regulation Of Actin Cytoskeleton Reorganization Cell Migration Cell Motility Regulation Of Ruffle Assembly Regulation Of Cell Cycle Negative Regulation Of Ras GTPase Activity Cell Cycle Process Cellular Senescence Regulation Of Long-term Neuronal Synaptic Plasticity Locomotion Negative Regulation Of GTPase Activity Regulation Of Synaptic Transmission, GABAergic Regulation Of Rac Protein Signal Transduction Regulation Of Actin Cytoskeleton Reorganization Cell Cycle Social Behavior Positive Regulation Of Wound Healing Epithelial Tube Branching Involved In Lung Morphogenesis Movement Of Cell Or Subcellular Component Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Cellular Response To Stress Positive Regulation Of Ras Protein Signal Transduction Positive Regulation Of Rac GTPase Activity Regulation Of Neuronal Synaptic Plasticity Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Small GTPase Mediated Signal Transduction Visual Learning Visual Behavior Activation Of MAPKK Activity	Regulation Of Lipid Kinase Activity Regulation Of Kinase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Negative Regulation Of Peptidyl-cysteine S-nitrosylation Regulation Of Phosphorus Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Communication Cellular Response To Fibroblast Growth Factor Stimulus Blood Coagulation Response To Fibroblast Growth Factor Hemostasis Regulation Of Catalytic Activity Neurotrophin TRK Receptor Signaling Pathway Ras Protein Signal Transduction Neurotrophin Signaling Pathway Intracellular Signal Transduction Leukocyte Migration Cell Cycle Regulation Of Cell Cycle Positive Regulation Of Macrophage Differentiation Fc Receptor Signaling Pathway Regulation Of Body Fluid Levels Cellular Response To Growth Factor Stimulus Wound Healing Response To Growth Factor Regulation Of Lipid Metabolic Process Regulation Of Cellular Localization Signaling Regulation Of Protein Phosphorylation Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Cellular Component Movement Regulation Of Cellular Component Movement Response To Wounding Positive Regulation Of Locomotion Positive Regulation Of ERK1 And ERK2 Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Protein Kinase Activity Mitotic Cell Cycle Regulation Of Epithelial Cell Migration Negative Regulation Of Catalytic Activity Regulation Of Muscle Contraction Organelle Localization Signal Transduction Regulation Of Immune System Process Innate Immune Response
Tagcloud ?		adenoma benign dampened delta erk feedback guanyl hras ilk insights integrin mechanistic neurofibromas null p27 pdpk1 peroxisome phosphoinositide pparbeta proliferator promotes releasing repression restore senescence shrna tumorigenesis turn upregulation
Tagcloud (Difference) ?		adenoma benign dampened delta erk feedback guanyl hras ilk insights integrin mechanistic neurofibromas null p27 pdpk1 peroxisome phosphoinositide pparbeta proliferator promotes releasing repression restore senescence shrna tumorigenesis turn upregulation
Tagcloud (Intersection) ?