RASGRP1

Description		RAS guanyl releasing protein 1
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GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Zinc Ion Binding Lipid Binding Diacylglycerol Binding GTPase Regulator Activity Phosphatidylcholine Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Inflammatory Response To Antigenic Stimulus Positive Regulation Of Immune System Process Signal Transduction Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Natural Killer Cell Activation Cell Differentiation Secretory Granule Localization Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Natural Killer Cell Differentiation Positive Regulation Of T Cell Differentiation In Thymus T Cell Proliferation B Cell Proliferation T Cell Activation B Cell Activation Mast Cell Degranulation Positive Regulation Of MAP Kinase Activity Leukocyte Activation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Ras Protein Signal Transduction Vesicle Transport Along Microtubule Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of ERK1 And ERK2 Cascade Activation Of GTPase Activity Regulation Of Intracellular Signal Transduction
Pathways		Effects of PIP2 hydrolysis Activation of RAS in B cells Activation of RAS in B cells FCERI mediated NF-kB activation Integrin signaling Rap1 signalling RAF/MAP kinase cascade
Drugs
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Bipolar disorder ( 18711365) Carboplatin disposition in epthelial ovarian cancer ( 29367611) Crohn's disease ( 23128233 28067908) Estimated glomerular filtration rate ( 30604766) Glucagon levels in response to oral glucose tolerance test (decremental area under the curve for 0-30 minutes) ( 33407418) Medication use (thyroid preparations) ( 31015401) Metabolite levels ( 23823483) Mild age-related type 2 diabetes ( 34737425) Multiple sclerosis ( 24076602) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701) Psychosis (atypical) ( 24132900) Rheumatoid arthritis ( 32723749 24390342 30423114 23143596 30572963) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Systemic lupus erythematosus ( 33272962 28714469) Type 1 diabetes ( 25751624 21829393 18840781) Type 2 diabetes ( 30718926 30297969 32499647 28254843 22961080)
Novel Interacting Genes		7 novel interacting genes: AQR CD19 DAP DNAH8 MAPK7 MGA TRIM33
Interacting Genes		2 interacting genes: DGKZ HRAS
Entrez ID		10125
HPRD ID		04909
Ensembl ID		ENSG00000172575
Uniprot IDs		B2RA89 O95267
PDB IDs		4L9M 4L9U
Enriched GO Terms of Interacting Partners?
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