RASGRP1

Gene Name		RAS guanyl releasing protein 1 (calcium and DAG-regulated)
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Gene Ontology Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Mast Cell Granule
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Lipid Binding
	Biological Process	Cytokine Production Inflammatory Response To Antigenic Stimulus Signal Transduction Ras Protein Signal Transduction Blood Coagulation Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Differentiation Platelet Activation Secretory Granule Localization Activation Of Rho GTPase Activity Fc-epsilon Receptor Signaling Pathway Mast Cell Degranulation Innate Immune Response Vesicle Transport Along Microtubule
Pathways		G alpha (q) signalling events Signaling by the B Cell Receptor (BCR) Signaling by GPCR Integrin alphaIIb beta3 signaling Platelet Aggregation (Plug Formation) Effects of PIP2 hydrolysis G alpha (q) signalling events Downstream signaling events of B Cell Receptor (BCR) GPCR downstream signaling FCERI mediated NF-kB activation Rap1 signalling Activation of RAS in B cells Gastrin-CREB signalling pathway via PKC and MAPK Fc epsilon receptor (FCERI) signaling Platelet activation, signaling and aggregation Adaptive Immune System Innate Immune System
Drugs
Diseases
GWAS		Bipolar disorder ( 18711365) Crohn's disease ( 23128233) Type 1 diabetes ( 18840781) Type 1 diabetes autoantibodies ( 21829393) Type 2 diabetes ( 22961080)
Protein-protein Interactions		2 interactors: DGKZ HRAS
Entrez ID		10125
HPRD ID		04909
Ensembl ID		ENSG00000172575
Uniprot IDs		B2RA89 F5H514 O95267
PDB IDs		4L9M 4L9U
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Checkpoint Negative Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Regulation Of Mitotic Cell Cycle Blood Coagulation Hemostasis Negative Regulation Of Cell Cycle Positive Regulation Of Rac Protein Signal Transduction Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Ruffle Assembly Regulation Of Body Fluid Levels Wound Healing Regulation Of Ras Protein Signal Transduction Mitotic Cell Cycle Process Regulation Of MiRNA Metabolic Process Response To Wounding Regulation Of Small GTPase Mediated Signal Transduction Mitotic Cell Cycle Negative Regulation Of Catalytic Activity Negative Regulation Of Rho GTPase Activity Positive Regulation Of Actin Cytoskeleton Reorganization Cell Migration Cell Motility Regulation Of Ruffle Assembly Regulation Of Cell Cycle Negative Regulation Of Ras GTPase Activity Cell Cycle Process Cellular Senescence Regulation Of Long-term Neuronal Synaptic Plasticity Locomotion Negative Regulation Of GTPase Activity Regulation Of Synaptic Transmission, GABAergic Regulation Of Rac Protein Signal Transduction Regulation Of Actin Cytoskeleton Reorganization Cell Cycle Social Behavior Positive Regulation Of Wound Healing Epithelial Tube Branching Involved In Lung Morphogenesis Movement Of Cell Or Subcellular Component Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Cellular Response To Stress Positive Regulation Of Ras Protein Signal Transduction Positive Regulation Of Rac GTPase Activity Regulation Of Neuronal Synaptic Plasticity Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Small GTPase Mediated Signal Transduction Visual Learning Visual Behavior Activation Of MAPKK Activity
Tagcloud ?		adenoma benign dampened delta erk feedback guanyl hras ilk insights integrin mechanistic neurofibromas null p27 pdpk1 peroxisome phosphoinositide pparbeta proliferator promotes releasing repression restore senescence shrna tumorigenesis turn upregulation