ATG4D and GABARAPL2

Number of citations of the paper that reports this interaction (PMID 19549685)
34

Data Source:
BioGRID (enzymatic study)

		ATG4D	GABARAPL2
Gene Name		autophagy related 4D, cysteine peptidase	GABA(A) receptor-associated protein-like 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrial Matrix Cytosol	Golgi Membrane Pre-autophagosomal Structure Autophagic Vacuole Membrane Intracellular Cytoplasm Autophagic Vacuole Golgi Apparatus Cytosol Extrinsic Component Of Membrane Cytoplasmic Vesicle
	Molecular Function	Cysteine-type Endopeptidase Activity	SNARE Binding Protein Binding Microtubule Binding Beta-tubulin Binding GABA Receptor Binding ATPase Binding
	Biological Process	Autophagic Vacuole Assembly Mitochondrion Degradation C-terminal Protein Lipidation Proteolysis Protein Targeting To Membrane Apoptotic Process Cellular Response To Nitrogen Starvation Protein Processing Nucleophagy Protein Delipidation	Autophagic Vacuole Assembly Mitochondrion Degradation Intra-Golgi Vesicle-mediated Transport Autophagy Cellular Response To Nitrogen Starvation Protein Transport Positive Regulation Of ATPase Activity Nucleophagy Membrane Fusion Negative Regulation Of Proteasomal Protein Catabolic Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: CASP3 CASP8 GABARAPL1 GABARAPL2	50 interactors: AAMP AGTRAP AHNAK2 APP ARFGAP1 ATG13 ATG3 ATG4A ATG4B ATG4D ATG7 BCL2L13 CALCOCO1 CALCOCO2 CCDC155 CLN8 EGFR FUNDC1 GIMAP6 GOSR1 KBTBD7 KIAA1958 KLHL5 KRTAP10-7 KRTAP10-9 LRSAM1 MAP1LC3B MLX NBR1 NSF PTPRA RAP1A RAP2A RCN2 RPS2 SGTA SIK2 SQSTM1 TBC1D25 TBC1D5 TBC1D9 TBC1D9B TNIP1 TP53INP2 TSR2 UBA5 ULK1 ULK2 VDR YWHAZ
Entrez ID		84971	11345
HPRD ID		07005	16246
Ensembl ID		ENSG00000130734	ENSG00000034713
Uniprot IDs		B4DGM8 Q86TL0	P60520
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleophagy Mitochondrion Degradation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Organelle Disassembly Mitochondrion Organization Autophagic Vacuole Assembly Macroautophagy Catabolic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Execution Phase Of Apoptosis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Proteolysis Activation Of Cysteine-type Endopeptidase Activity Extrinsic Apoptotic Signaling Pathway Zymogen Activation Vacuole Organization Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Response To Tumor Necrosis Factor Membrane Fusion Positive Regulation Of Endopeptidase Activity Cellular Response To Starvation Positive Regulation Of Peptidase Activity Autophagy Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Positive Regulation Of Hydrolase Activity Cellular Response To Nutrient Levels Response To Starvation Intrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Response To Stress TRAIL-activated Apoptotic Signaling Pathway Cellular Response To Extracellular Stimulus Protein Processing Myeloid Cell Differentiation Positive Regulation Of Proteolysis Cellular Response To Stress Positive Regulation Of Catalytic Activity Glial Cell Apoptotic Process Regulation Of Apoptotic DNA Fragmentation Apoptotic Signaling Pathway Regulation Of Endopeptidase Activity Response To External Stimulus Regulation Of Peptidase Activity Response To Nutrient Levels Positive Regulation Of Macrophage Differentiation Cellular Component Assembly Negative Regulation Of Activated T Cell Proliferation Response To Cobalt Ion	Autophagy Macroautophagy Response To Starvation Cellular Response To Nutrient Levels Cellular Response To Starvation Autophagic Vacuole Assembly Cellular Response To Extracellular Stimulus Response To Nutrient Levels Response To Extracellular Stimulus Vacuole Organization Mitochondrion Degradation Organelle Disassembly Nucleophagy Membrane Organization Positive Regulation Of Autophagy Response To Stress Cellular Response To Nitrogen Starvation Catabolic Process Regulation Of Autophagy Response To External Stimulus Protein Localization Establishment Of Protein Localization Protein Delipidation Mitochondrion Organization Cellular Response To Stress Positive Regulation Of Metabolic Process Organelle Assembly C-terminal Protein Lipidation Establishment Of Protein Localization To Membrane Protein Localization To Membrane Protein Transport Positive Regulation Of Cellular Metabolic Process Intracellular Transport Cellular Localization Cell Communication Positive Regulation Of Macroautophagy Cellular Component Assembly Response To Stimulus Establishment Of Localization In Cell Cellular Response To Stimulus Protein Targeting To Membrane Regulation Of Signaling Regulation Of Signal Transduction Organelle Organization Cellular Metabolic Process Protein Lipidation Lipoprotein Biosynthetic Process Negative Regulation Of Collateral Sprouting Positive Regulation Of Catalytic Activity Positive Regulation Of Hydrolase Activity
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