ATG4D and GABARAPL2

Number of citations of the paper that reports this interaction (PubMedID 19549685)
47

Data Source:
BioGRID (enzymatic study)

		ATG4D	GABARAPL2
Description		autophagy related 4D cysteine peptidase	GABA type A receptor associated protein like 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix	Golgi Membrane Autophagosome Membrane Cytoplasm Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Cytoplasmic Vesicle
	Molecular Function	Cysteine-type Endopeptidase Activity Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Protein-phosphatidylethanolamide Deconjugating Activity Cysteine-type Exopeptidase Activity	SNARE Binding Protein Binding Phospholipid Binding Microtubule Binding Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding GABA Receptor Binding ATPase Binding
	Biological Process	Autophagosome Assembly Mitophagy Proteolysis Autophagy Apoptotic Process Protein Transport Protein Processing Protein Localization To Phagophore Assembly Site Piecemeal Microautophagy Of The Nucleus Aggrephagy Protein Delipidation	Autophagosome Assembly Mitophagy Intra-Golgi Vesicle-mediated Transport Autophagy Cellular Response To Nitrogen Starvation Protein Transport Positive Regulation Of ATP-dependent Activity Protein Localization To Endoplasmic Reticulum Autophagosome Maturation Negative Regulation Of Proteasomal Protein Catabolic Process
Pathways		Macroautophagy	Macroautophagy TBC/RABGAPs
Drugs
Diseases
GWAS			Age at first sexual intercourse ( 34211149) Blood protein levels ( 30072576) Pancreatic cancer ( 25086665)
Interacting Genes		7 interacting genes: CASP3 CASP8 GABARAP GABARAPL1 GABARAPL2 MAP1LC3B TRIM55	103 interacting genes: AAMP AGTRAP AHNAK2 AMBRA1 ANK2 APP APPL1 ARFGAP1 ATG13 ATG3 ATG4A ATG4B ATG4D ATG7 AZI2 BCL2L13 BICC1 BNIP3L BRD9 BSDC1 CALCOCO1 CALCOCO2 CARS2 CDC37 CEBPA CLN8 CUL3 DYNLL1 DYNLL2 EGFR ERBB2 ERBB3 ERBB4 FUNDC1 GIMAP6 GOSR1 GPR37 HAP1 INSYN1 KASH5 KBTBD6 KBTBD7 KIAA1958 KIF16B KLHL5 KRTAP10-7 KRTAP10-9 LRSAM1 LZTR1 MAP4K2 MCPH1 MEF2A MEFV MLX MRPL49 MYBPC1 NBR1 NCOR1 NEDD4 NPSR1 NSF NUDT15 OPTN OSBPL3 OSBPL7 PDLIM1 PTPRA RAP1A RAP2A RB1CC1 RCN2 RESF1 RETREG1 RETREG3 RPS2 SCYL3 SEPTIN3 SGTA SIK2 SMO SQSTM1 TAX1BP1 TBC1D25 TBC1D5 TBC1D9 TBC1D9B TEX264 TNIP1 TP53INP1 TP53INP2 TRIM21 TRIM25 TRIM32 TRIM45 TSR2 UBA5 ULK1 ULK2 VDR WDFY3 YWHAZ ZBTB2 ZNF774
Entrez ID		84971	11345
HPRD ID		07005	16246
Ensembl ID		ENSG00000130734	ENSG00000034713
Uniprot IDs		B4DGM8 Q86TL0	P60520
PDB IDs			4CO7 6H8C 7LK3 7YO8 8Q6Q
Enriched GO Terms of Interacting Partners?		Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Autophagosome Assembly Autophagosome Organization Autophagosome Maturation Vacuole Organization Autophagosome Membrane Mitophagy Autophagy Of Mitochondrion Autophagosome GABA Receptor Binding Ubiquitin Protein Ligase Binding Phospholipid Binding Protein-containing Complex Disassembly Macroautophagy Beta-tubulin Binding Cellular Response To Starvation Response To Starvation Response To Anesthetic Cellular Response To Nutrient Levels Death-inducing Signaling Complex Organelle Assembly Autophagy Positive Regulation Of Pyroptotic Inflammatory Response Response To Cobalt Ion Microtubule Death Receptor Binding Response To Nutrient Levels Response To Stress Execution Phase Of Apoptosis Pyroptotic Inflammatory Response Microtubule Binding Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Organelle Organization Cellular Response To Stress Apoptotic Signaling Pathway Cytoplasmic Vesicle Cysteine-type Endopeptidase Activity Positive Regulation Of Neuron Apoptotic Process Regulation Of Proteolysis Catabolic Process Phospholipase A2 Activator Activity Response To Estradiol Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Response To Tumor Necrosis Factor Extrinsic Apoptotic Signaling Pathway Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Positive Regulation Of Protein K48-linked Ubiquitination Axoneme Cysteine-type Peptidase Activity	Autophagosome Autophagy Macroautophagy Autophagy Of Mitochondrion Mitophagy Autophagosome Assembly Autophagosome Organization Catabolic Process Nucleophagy Vacuole Organization Piecemeal Microautophagy Of The Nucleus Phagophore Assembly Site Microautophagy Positive Regulation Of Autophagy Regulation Of Autophagy Positive Regulation Of Catabolic Process Cytosol Reticulophagy Cytoplasm Aggrephagy Cytoplasmic Vesicle Intracellular Protein Localization Organelle Assembly Atg1/ULK1 Kinase Complex Organelle Organization Positive Regulation Of Macroautophagy Protein Polyubiquitination Regulation Of Intracellular Signal Transduction Regulation Of Macroautophagy Protein-phosphatidylethanolamide Deconjugating Activity Autophagosome Membrane Macromolecule Catabolic Process Response To Stress Regulation Of Signal Transduction Protein Delipidation Regulation Of Signaling Receptor Complex Protein Modification Process Protein K48-linked Ubiquitination Response To Mitochondrial Depolarisation Protein Modification By Small Protein Conjugation Positive Regulation Of Metabolic Process Regulation Of Cell Communication Establishment Of Protein Localization Protein Binding Phagophore Assembly Site Membrane ERBB2 Signaling Pathway Regulation Of MAPK Cascade Protein Metabolic Process Identical Protein Binding
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