SPRYD3 and MYCBP2

Number of citations of the paper that reports this interaction (PubMedID 21653829)
54

Data Source:
BioGRID (two hybrid)

		SPRYD3	MYCBP2
Description		SPRY domain containing 3	MYC binding protein 2
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GO Annotations	Cellular Component		Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Microtubule Cytoskeleton Membrane Axon Cell Projection
	Molecular Function		Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Transferase Activity Small GTPase Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process		Axon Guidance Motor Neuron Axon Guidance Regulation Of Synaptic Assembly At Neuromuscular Junction Protein Ubiquitination Branchiomotor Neuron Axon Guidance Central Nervous System Projection Neuron Axonogenesis Positive Regulation Of Protein Ubiquitination Regulation Of Protein Localization Circadian Regulation Of Gene Expression Negative Regulation Of Protein Catabolic Process Rhythmic Process Cell Morphogenesis Involved In Neuron Differentiation Neuromuscular Process Regulation Of Cytoskeleton Organization Axon Development Protein K48-linked Ubiquitination Regulation Of Axon Guidance
Pathways
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172)	Chronotype ( 30696823) Iris heterochromicity ( 30895295) Morning person ( 30696823) Preeclampsia ( 23551011) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)
Interacting Genes		1 interacting genes: MYCBP2	50 interacting genes: AATF APPL1 ARL6IP5 ASB8 ATP13A2 BTG3 CALM1 CD81 CEBPA CFL1 CUEDC2 DHRS4L2 DSCR9 DYRK1A ERBB3 FHL3 FSCN1 HSP90AB1 HUNK IGFBP6 LCOR LDHB LSM14A MYC NDUFB9 NMNAT2 OAZ1 PABPN1 PI4KB PRXL2A PTPN12 PUF60 RGPD8 RPS5 RSPH1 SERPINB6 SOD1 SPARCL1 SPRYD3 SRPK2 TBC1D9 TBC1D9B TBR1 TTN UBE2D2 UBE2D3 UBE2L3 UCHL1 YWHAG YWHAQ
Entrez ID		84926	23077
HPRD ID		08603	10104
Ensembl ID		ENSG00000167778	ENSG00000005810
Uniprot IDs		Q8NCJ5	O75592
PDB IDs		2YYO	5O6C 6T7F
Enriched GO Terms of Interacting Partners?		Branchiomotor Neuron Axon Guidance Regulation Of Axon Guidance Regulation Of Synaptic Assembly At Neuromuscular Junction Motor Neuron Axon Guidance Cell Morphogenesis Involved In Neuron Differentiation Central Nervous System Projection Neuron Axonogenesis Central Nervous System Neuron Axonogenesis Axon Development Circadian Regulation Of Gene Expression	Cytoplasm Intracellular Signal Transduction
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