LINC00839 and RAPGEF6

Number of citations of the paper that reports this interaction (PubMedID 30631154)
76

Data Source:
BioGRID (unspecified method)

		LINC00839	RAPGEF6
Description		long intergenic non-protein coding RNA 839	Rap guanine nucleotide exchange factor 6
Image		No pdb structure
GO Annotations	Cellular Component		Cytoplasm Centrosome Cytosol Plasma Membrane Membrane Apical Plasma Membrane Endocytic Vesicle
	Molecular Function		Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP-dependent Protein Binding Small GTPase Binding Phosphatidic Acid Binding
	Biological Process		Signal Transduction Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Microvillus Assembly Regulation Of GTPase Activity Protein Localization To Plasma Membrane Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Microvillus Assembly
Pathways
Drugs
Diseases
GWAS			Alzheimer's disease in APOE e4- carriers ( 25778476) Asthma ( 32296059) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Diisocyanate-induced asthma ( 25918132) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mosquito bite size ( 28199695) Perceived unattractiveness to mosquitoes ( 28199695) Subcortical volume (MOSTest) ( 32665545) Subjective well-being ( 27089181) Ulcerative colitis ( 28067908)
Interacting Genes		82 interacting genes: ADAMTS15 AKAP13 ALDH16A1 APOL3 BFSP1 CALM1 CC2D1B CCDC93 CDC16 CEP192 CEP295NL CHPF CIZ1 CLGN CLPTM1 COPB1 DNAH10 DPEP3 EFL1 EID2 EMX1 FAAP100 FAM13B FBXL5 HAPLN4 IQCN IRX4 JAKMIP2 KLK14 KRT1 KRT6B L1CAM LRTM3 MEX3A MEX3B MEX3C MEX3D MICAL2 MYO7A NDUFA2 NOC4L NOTCH3 NVL OS9 P4HB PABPN1 PALM3 PARP6 PHACTR1 PKD1L2 PLOD3 PNPLA3 POMT2 PRSS1 PRSS3 PTBP1 PTEN PTPRA QSOX2 RAPGEF6 RIF1 RPLP2 RPTOR RYR2 SEMA4D SEPTIN12 SEPTIN9 SERHL2 SLC7A14 SOWAHB SREBF2 SYNE1 SYNE3 TAS1R3 TCF24 TMC4 TRO UBE2S VANGL1 YAP1 YIPF1 ZFPL1	8 interacting genes: ABCA1 LINC00839 MRAS NEDD4 PTPN13 RAP1A RAP2A YWHAG
Entrez ID		84856	51735
HPRD ID		17516	11483
Ensembl ID		ENSG00000185904	ENSG00000158987
Uniprot IDs			B2RTU6 Q8TEU7
PDB IDs			2D93 3LNY
Enriched GO Terms of Interacting Partners?			GDP Binding G Protein Activity Rap Protein Signal Transduction Regulation Of Cellular Component Organization Regulation Of Intracellular Signal Transduction Sphingolipid Floppase Activity Regulation Of Developmental Process Protein Localization To Lysosome Regulation Of Dendrite Morphogenesis Regulation Of Synapse Organization Formation Of Structure Involved In A Symbiotic Process Regulation Of Cell Junction Assembly GTPase Activity Small GTPase-mediated Signal Transduction Response To Vitamin B3 Intracellular Protein Localization Positive Regulation Of High-density Lipoprotein Particle Assembly Apolipoprotein A-I Receptor Activity Phagocytic Vesicle Protein Localization To Vacuole Channel Inhibitor Activity Intracellular Signal Transduction Regulation Of Dendrite Development Negative Regulation Of Excitatory Synapse Assembly Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Response To Antineoplastic Agent GTP Binding Regulation Of Neuron Projection Development Negative Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Regulation Of High-density Lipoprotein Particle Assembly Phosphothreonine Residue Binding Protein Kinase C Inhibitor Activity Negative Regulation Of Phosphorylation Phosphatidylserine Floppase Activity Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Extracellular Exosome Apolipoprotein A-I-mediated Signaling Pathway Regulation Of Cell Communication Floppase Activity Sphingolipid Translocation Establishment Of Protein Localization Lipoprotein Biosynthetic Process Phosphatidylcholine Floppase Activity Signal Release Apolipoprotein A-I Binding Regulation Of Signaling Phosphoserine Residue Binding Nuclear Receptor-mediated Corticosteroid Signaling Pathway
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