RAPGEF6 and MRAS

Number of citations of the paper that reports this interaction (PMID 11524421)
11

Data Source:
HPRD (in vitro, in vivo)

		RAPGEF6	MRAS
Gene Name		Rap guanine nucleotide exchange factor (GEF) 6	muscle RAS oncogene homolog
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Apical Plasma Membrane Endocytic Vesicle	Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Ras GTPase Binding GTP-dependent Protein Binding Phosphatidic Acid Binding	GTPase Activity GTP Binding GTP-dependent Protein Binding
	Biological Process	Ras Protein Signal Transduction Microvillus Assembly Positive Regulation Of Rap GTPase Activity Regulation Of GTPase Activity Protein Localization To Plasma Membrane Establishment Of Endothelial Intestinal Barrier	Ras Protein Signal Transduction Multicellular Organismal Development Muscle Organ Development Actin Cytoskeleton Organization
Pathways
Drugs
Diseases
GWAS			Coronary heart disease ( 19198612 21378990)
Protein-Protein Interactions		7 interactors: ABCA1 MRAS NEDD4 PTPN13 RAP1A RAP2A YWHAG	10 interactors: BRAF MLLT4 PIK3CA RAF1 RALGDS RAPGEF5 RAPGEF6 RASIP1 RASSF5 TCEB1
Entrez ID		51735	22808
HPRD ID		11483	06662
Ensembl ID		ENSG00000158987	ENSG00000158186
Uniprot IDs		B2RTU6 Q8TEU7	O14807 Q6FGP0 Q8WVM9
PDB IDs		2D93 3LNY
Enriched GO Terms of Interacting Partners?		Rap Protein Signal Transduction Regulation Of Neuron Differentiation Regulation Of Signal Transduction Establishment Of Protein Localization Regulation Of Cell Differentiation Regulation Of Neurogenesis Ras Protein Signal Transduction Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Cell Development Protein Localization Regulation Of Neuron Projection Development Regulation Of Dendrite Morphogenesis Regulation Of Cell Projection Organization Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Transmission Of Virus Development Involved In Symbiotic Interaction Protein Transport Regulation Of Dendrite Development Regulation Of Phosphorus Metabolic Process Generation Of Neurons Small GTPase Mediated Signal Transduction Signal Transduction Neurogenesis Positive Regulation Of Transport Signaling Intracellular Signal Transduction Cellular Response To Organic Substance Interleukin-1 Beta Secretion Cell Communication Regulation Of Cellular Component Organization Membrane Organization Apolipoprotein A-I-mediated Signaling Pathway Progesterone Receptor Signaling Pathway Interleukin-1 Secretion Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Transport Negative Regulation Of Cholesterol Storage High-density Lipoprotein Particle Assembly Nervous System Development Glucocorticoid Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Cellular Localization System Development Intracellular Cholesterol Transport Intracellular Sterol Transport Phospholipid Homeostasis Regulation Of Protein Phosphorylation	Positive Regulation Of Rap GTPase Activity Regulation Of Rap GTPase Activity Regulation Of Rap Protein Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Regulation Of Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Intracellular Signal Transduction Small GTPase Mediated Signal Transduction Cellular Response To Stimulus Regulation Of Ras Protein Signal Transduction Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of GTPase Activity Regulation Of Peptidyl-serine Phosphorylation Signal Transduction Regulation Of Metabolic Process Signaling Cell Communication Response To Stimulus Regulation Of Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Ras GTPase Activity Regulation Of Signaling Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Cellular Response To Growth Factor Stimulus Response To Growth Factor Ras Protein Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of GTPase Activity Activation Of MAPKK Activity Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Somatic Stem Cell Maintenance Death-inducing Signaling Complex Assembly Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Hydrolase Activity Positive Regulation Of Ras GTPase Activity Response To Peptide Hormone Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Hypomethylation Of CpG Island Response To Peptide Positive Regulation Of Kinase Activity Regulation Of Cellular Ketone Metabolic Process Regulation Of Cellular Process
Tagcloud ?			acetylcholine anion antihypertensive assume bioavailability cuff cyclooxygenase deleterious deoxycorticosterone doca gavage hypertension hypertensive mesenteric myograph nad nak nakatpase ouabain reasonable relaxation rosta rostafuroxin salt sbp uninephrectomized wire wistar
Tagcloud (Difference) ?			acetylcholine anion antihypertensive assume bioavailability cuff cyclooxygenase deleterious deoxycorticosterone doca gavage hypertension hypertensive mesenteric myograph nad nak nakatpase ouabain reasonable relaxation rosta rostafuroxin salt sbp uninephrectomized wire wistar
Tagcloud (Intersection) ?