RAPGEF6

Gene Name		Rap guanine nucleotide exchange factor (GEF) 6
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Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Apical Plasma Membrane Endocytic Vesicle
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Ras GTPase Binding GTP-dependent Protein Binding Phosphatidic Acid Binding
	Biological Process	Ras Protein Signal Transduction Microvillus Assembly Positive Regulation Of Rap GTPase Activity Regulation Of GTPase Activity Protein Localization To Plasma Membrane Establishment Of Endothelial Intestinal Barrier
Pathways
Drugs
Diseases
GWAS
Protein-protein Interactions		7 interactors: ABCA1 MRAS NEDD4 PTPN13 RAP1A RAP2A YWHAG
Entrez ID		51735
HPRD ID		11483
Ensembl ID		ENSG00000158987
Uniprot IDs		B2RTU6 Q8TEU7
PDB IDs		2D93 3LNY
Enriched GO Terms of Interacting Partners?		Rap Protein Signal Transduction Regulation Of Neuron Differentiation Regulation Of Signal Transduction Establishment Of Protein Localization Regulation Of Cell Differentiation Regulation Of Neurogenesis Ras Protein Signal Transduction Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Cell Development Protein Localization Regulation Of Neuron Projection Development Regulation Of Dendrite Morphogenesis Regulation Of Cell Projection Organization Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Transmission Of Virus Development Involved In Symbiotic Interaction Protein Transport Regulation Of Dendrite Development Regulation Of Phosphorus Metabolic Process Generation Of Neurons Small GTPase Mediated Signal Transduction Signal Transduction Neurogenesis Positive Regulation Of Transport Signaling Intracellular Signal Transduction Cellular Response To Organic Substance Interleukin-1 Beta Secretion Cell Communication Regulation Of Cellular Component Organization Membrane Organization Apolipoprotein A-I-mediated Signaling Pathway Progesterone Receptor Signaling Pathway Interleukin-1 Secretion Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Transport Negative Regulation Of Cholesterol Storage High-density Lipoprotein Particle Assembly Nervous System Development Glucocorticoid Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Cellular Localization System Development Intracellular Cholesterol Transport Intracellular Sterol Transport Phospholipid Homeostasis Regulation Of Protein Phosphorylation
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