Wiki-Pi
Answer Survey
Home
About
Help
Advanced Search
RAPGEF6 and PTPN13
Number of citations of the paper that reports this interaction (PMID
12095257
)
18
Data Source:
HPRD
(in vitro, two hybrid)
RAPGEF6
PTPN13
Gene Name
Rap guanine nucleotide exchange factor (GEF) 6
protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
Image
Gene Ontology Annotations
Cellular Component
Cytosol
Plasma Membrane
Apical Plasma Membrane
Endocytic Vesicle
Nucleus
Cytoplasm
Cytoskeleton
Plasma Membrane
Lamellipodium
Neuron Projection
Cell Body
Extracellular Vesicular Exosome
Molecular Function
Guanyl-nucleotide Exchange Factor Activity
Protein Binding
Ras GTPase Binding
GTP-dependent Protein Binding
Phosphatidic Acid Binding
Protein Tyrosine Phosphatase Activity
Protein Binding
Phosphatidylinositol 3-kinase Regulatory Subunit Binding
Biological Process
Ras Protein Signal Transduction
Microvillus Assembly
Positive Regulation Of Rap GTPase Activity
Regulation Of GTPase Activity
Protein Localization To Plasma Membrane
Establishment Of Endothelial Intestinal Barrier
Protein Dephosphorylation
Regulation Of Phosphatidylinositol 3-kinase Signaling
Peptidyl-tyrosine Dephosphorylation
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions
7 interactors:
ABCA1
MRAS
NEDD4
PTPN13
RAP1A
RAP2A
YWHAG
21 interactors:
APC
ARHGAP29
BRD7
CRIP2
CTNNB1
EFNB1
EFNB2
FADD
FAS
FASLG
GHR
NFKBIA
NGFR
NGFRAP1
PDLIM4
PKN2
PLEKHA1
PRKACA
RAPGEF6
TRIP6
YWHAZ
Entrez ID
51735
5783
HPRD ID
11483
02602
Ensembl ID
ENSG00000158987
ENSG00000163629
Uniprot IDs
B2RTU6
Q8TEU7
Q12923
PDB IDs
2D93
3LNY
1D5G
1Q7X
1WCH
2M0Z
2M10
3LNX
3LNY
3PDZ
Enriched GO Terms of Interacting Partners
?
Rap Protein Signal Transduction
Regulation Of Neuron Differentiation
Regulation Of Signal Transduction
Establishment Of Protein Localization
Regulation Of Cell Differentiation
Regulation Of Neurogenesis
Ras Protein Signal Transduction
Regulation Of Signaling
Regulation Of Intracellular Signal Transduction
Regulation Of Cell Development
Protein Localization
Regulation Of Neuron Projection Development
Regulation Of Dendrite Morphogenesis
Regulation Of Cell Projection Organization
Regulation Of Phosphatidylinositol 3-kinase Signaling
Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage
Transmission Of Virus
Development Involved In Symbiotic Interaction
Protein Transport
Regulation Of Dendrite Development
Regulation Of Phosphorus Metabolic Process
Generation Of Neurons
Small GTPase Mediated Signal Transduction
Signal Transduction
Neurogenesis
Positive Regulation Of Transport
Signaling
Intracellular Signal Transduction
Cellular Response To Organic Substance
Interleukin-1 Beta Secretion
Cell Communication
Regulation Of Cellular Component Organization
Membrane Organization
Apolipoprotein A-I-mediated Signaling Pathway
Progesterone Receptor Signaling Pathway
Interleukin-1 Secretion
Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage
Regulation Of Protein Metabolic Process
Positive Regulation Of Intracellular Transport
Negative Regulation Of Cholesterol Storage
High-density Lipoprotein Particle Assembly
Nervous System Development
Glucocorticoid Receptor Signaling Pathway
Cellular Response To Stimulus
Regulation Of Cellular Localization
System Development
Intracellular Cholesterol Transport
Intracellular Sterol Transport
Phospholipid Homeostasis
Regulation Of Protein Phosphorylation
Signal Transduction
Signaling
Cell Communication
Apoptotic Process
Programmed Cell Death
Cell Death
Death
Cellular Response To Stimulus
Regulation Of Signal Transduction
Regulation Of Myeloid Cell Differentiation
Regulation Of Cell Proliferation
Regulation Of Signaling
Cell Surface Receptor Signaling Pathway
Necroptotic Signaling Pathway
Apoptotic Signaling Pathway
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Cell Death
Positive Regulation Of Signal Transduction
Response To Stimulus
Regulation Of Intracellular Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Regulation Of Apoptotic Process
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Cell Death
Cell Adhesion
T Cell Differentiation In Thymus
Regulation Of Protein Metabolic Process
Enzyme Linked Receptor Protein Signaling Pathway
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Cell Junction Assembly
Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Negative Regulation Of Cell Death
Cell-cell Junction Organization
Motor Neuron Apoptotic Process
Regulation Of Cysteine-type Endopeptidase Activity
Regulation Of Proteolysis
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Cellular Process
Activation Of Cysteine-type Endopeptidase Activity
Regulation Of Cellular Protein Metabolic Process
Extrinsic Apoptotic Signaling Pathway
Zymogen Activation
Regulation Of Myeloid Leukocyte Differentiation
Necroptotic Process
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Tagcloud
?
adenocarcinomas
atxn2
biology
consistently
couple
deregulation
dhx9
driver
exome
hundreds
kras
mutations
myof
never
overlap
preferentially
recurrent
respective
rps6kb2
seq
sequenced
smokers
somatic
sp1
sptan1
stratification
targetable
ten
thousands
Tagcloud (Difference)
?
adenocarcinomas
atxn2
biology
consistently
couple
deregulation
dhx9
driver
exome
hundreds
kras
mutations
myof
never
overlap
preferentially
recurrent
respective
rps6kb2
seq
sequenced
smokers
somatic
sp1
sptan1
stratification
targetable
ten
thousands
Tagcloud (Intersection)
?