LINC00839 and POMT2

Number of citations of the paper that reports this interaction (PubMedID 30631154)
76

Data Source:
BioGRID (unspecified method)

		LINC00839	POMT2
Description		long intergenic non-protein coding RNA 839	protein O-mannosyltransferase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Nucleoplasm Nucleolus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane
	Molecular Function		Mannosyltransferase Activity Dolichyl-phosphate-mannose-protein Mannosyltransferase Activity Transferase Activity Glycosyltransferase Activity Metal Ion Binding
	Biological Process		Protein Glycosylation Protein O-linked Glycosylation Dentate Gyrus Development Protein O-linked Glycosylation Via Mannose Basement Membrane Organization Reactive Gliosis
Pathways			Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 DAG1 core M2 glycosylations DAG1 core M3 glycosylations DAG1 core M1 glycosylations Regulation of CDH1 posttranslational processing and trafficking to plasma membrane
Drugs
Diseases			Dystroglycanopathy; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama congenital muscular dystrophy (FCMD); Congenital muscular dystrophy with muscle hypertrophy (MDC1C); Congenital muscular dystrophy with severe intellectual impairment and abnormal glycosylation (MDC1D) Limb-girdle muscular dystrophy (LGMD) Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy
GWAS
Interacting Genes		82 interacting genes: ADAMTS15 AKAP13 ALDH16A1 APOL3 BFSP1 CALM1 CC2D1B CCDC93 CDC16 CEP192 CEP295NL CHPF CIZ1 CLGN CLPTM1 COPB1 DNAH10 DPEP3 EFL1 EID2 EMX1 FAAP100 FAM13B FBXL5 HAPLN4 IQCN IRX4 JAKMIP2 KLK14 KRT1 KRT6B L1CAM LRTM3 MEX3A MEX3B MEX3C MEX3D MICAL2 MYO7A NDUFA2 NOC4L NOTCH3 NVL OS9 P4HB PABPN1 PALM3 PARP6 PHACTR1 PKD1L2 PLOD3 PNPLA3 POMT2 PRSS1 PRSS3 PTBP1 PTEN PTPRA QSOX2 RAPGEF6 RIF1 RPLP2 RPTOR RYR2 SEMA4D SEPTIN12 SEPTIN9 SERHL2 SLC7A14 SOWAHB SREBF2 SYNE1 SYNE3 TAS1R3 TCF24 TMC4 TRO UBE2S VANGL1 YAP1 YIPF1 ZFPL1	3 interacting genes: GLP1R LINC00839 POMT1
Entrez ID		84856	29954
HPRD ID		17516	09592
Ensembl ID		ENSG00000185904	ENSG00000009830
Uniprot IDs			Q9UKY4
PDB IDs
Enriched GO Terms of Interacting Partners?			Glucagon-like Peptide 1 Receptor Activity Dolichyl-phosphate-mannose-protein Mannosyltransferase Complex Response To Psychosocial Stress Glucagon Receptor Activity Dolichyl-phosphate-mannose-protein Mannosyltransferase Activity Post-translational Protein Targeting To Membrane, Translocation Cellular Response To Glucagon Stimulus Protein O-linked Glycosylation Via Mannose Mannosyltransferase Activity Activation Of Adenylate Cyclase Activity Positive Regulation Of Lyase Activity Positive Regulation Of Adenylate Cyclase Activity Response To Glucagon Positive Regulation Of Cyclase Activity Intracellular Protein Transmembrane Transport Positive Regulation Of Blood Pressure Peptide Hormone Binding G Protein-coupled Peptide Receptor Activity Negative Regulation Of Blood Pressure
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