RAPGEF6 and RAP2A

Number of citations of the paper that reports this interaction (PMID 12581858)
13

Data Source:
HPRD (in vivo, in vitro)

		RAPGEF6	RAP2A
Gene Name		Rap guanine nucleotide exchange factor (GEF) 6	RAP2A, member of RAS oncogene family
Image
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Apical Plasma Membrane Endocytic Vesicle	Cytosol Plasma Membrane Midbody Recycling Endosome Recycling Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Ras GTPase Binding GTP-dependent Protein Binding Phosphatidic Acid Binding	GTPase Activity Protein Binding GTP Binding
	Biological Process	Ras Protein Signal Transduction Microvillus Assembly Positive Regulation Of Rap GTPase Activity Regulation Of GTPase Activity Protein Localization To Plasma Membrane Establishment Of Endothelial Intestinal Barrier	Positive Regulation Of Protein Phosphorylation Microvillus Assembly Negative Regulation Of Cell Migration Actin Cytoskeleton Reorganization Positive Regulation Of Protein Autophosphorylation Rap Protein Signal Transduction Cellular Protein Localization Cellular Response To Drug Establishment Of Protein Localization Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of JNK Cascade Regulation Of Dendrite Morphogenesis Protein Localization To Plasma Membrane
Pathways
Drugs			Guanosine-5\'-Triphosphate Guanosine-5\'-Diphosphate
Diseases
GWAS
Protein-Protein Interactions		7 interactors: ABCA1 MRAS NEDD4 PTPN13 RAP1A RAP2A YWHAG	32 interactors: ACVR1 ARHGAP29 BMPR1B EEF1A1 ENSA FKBP2 FNTB FTL GABARAPL2 GRIN1 GRIN2D MAP4K4 MLLT4 NEDD4 PLG RAF1 RALA RALGDS RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASIP1 RASSF5 RGS14 RRP9 RUNDC3A SERPINA1 SMAD1 TGFBR1 TM7SF2 TNIK
Entrez ID		51735	5911
HPRD ID		11483	01547
Ensembl ID		ENSG00000158987
Uniprot IDs		B2RTU6 Q8TEU7	P10114
PDB IDs		2D93 3LNY	1KAO 2RAP 3RAP
Enriched GO Terms of Interacting Partners?		Rap Protein Signal Transduction Regulation Of Neuron Differentiation Regulation Of Signal Transduction Establishment Of Protein Localization Regulation Of Cell Differentiation Regulation Of Neurogenesis Ras Protein Signal Transduction Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Cell Development Protein Localization Regulation Of Neuron Projection Development Regulation Of Dendrite Morphogenesis Regulation Of Cell Projection Organization Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Transmission Of Virus Development Involved In Symbiotic Interaction Protein Transport Regulation Of Dendrite Development Regulation Of Phosphorus Metabolic Process Generation Of Neurons Small GTPase Mediated Signal Transduction Signal Transduction Neurogenesis Positive Regulation Of Transport Signaling Intracellular Signal Transduction Cellular Response To Organic Substance Interleukin-1 Beta Secretion Cell Communication Regulation Of Cellular Component Organization Membrane Organization Apolipoprotein A-I-mediated Signaling Pathway Progesterone Receptor Signaling Pathway Interleukin-1 Secretion Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Transport Negative Regulation Of Cholesterol Storage High-density Lipoprotein Particle Assembly Nervous System Development Glucocorticoid Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Cellular Localization System Development Intracellular Cholesterol Transport Intracellular Sterol Transport Phospholipid Homeostasis Regulation Of Protein Phosphorylation	Intracellular Signal Transduction Response To Stimulus Regulation Of Signaling Regulation Of Catalytic Activity Cell Communication Signal Transduction Cellular Response To Stimulus Positive Regulation Of Metabolic Process Positive Regulation Of Rap GTPase Activity Signaling Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Rap GTPase Activity Positive Regulation Of Catalytic Activity Regulation Of Rap Protein Signal Transduction Signal Transduction By Phosphorylation Regulation Of Metabolic Process Small GTPase Mediated Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Regulation Of GTPase Activity Wound Healing Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Ras Protein Signal Transduction Regulation Of Dendrite Morphogenesis Response To Wounding Regulation Of Cell Projection Organization Positive Regulation Of GTPase Activity Positive Regulation Of Hydrolase Activity Platelet Activation Regulation Of Ras GTPase Activity Cellular Response To Growth Factor Stimulus Response To Organic Substance Regulation Of Cellular Process Response To Growth Factor Regulation Of Dendrite Development Cardiovascular System Development Cell Surface Receptor Signaling Pathway Positive Regulation Of Ras GTPase Activity Regulation Of Cell Differentiation Negative Regulation Of Cell Proliferation Cell Activation Regulation Of Cellular Localization Cell Differentiation Blood Vessel Development Response To Stress Vasculature Development Regulation Of Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Activation Of MAPKK Activity
Tagcloud ?			cleave competitors degrades diaminopimelic effectors endopeptidase endopeptidases exploiting extrude heteromeric marcescens meso muropeptides neutralization neutralize orthologues pentapeptides promiscuity rap1a raps serratia ssp1 ssp2 steric tetrapenta tetrapeptides tetratetra tetratetrapeptides tripeptides
Tagcloud (Difference) ?			cleave competitors degrades diaminopimelic effectors endopeptidase endopeptidases exploiting extrude heteromeric marcescens meso muropeptides neutralization neutralize orthologues pentapeptides promiscuity rap1a raps serratia ssp1 ssp2 steric tetrapenta tetrapeptides tetratetra tetratetrapeptides tripeptides
Tagcloud (Intersection) ?