NFKBID and IKZF3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NFKBID	IKZF3
Description		NFKB inhibitor delta	IKAROS family zinc finger 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding Protein Heterodimerization Activity Promoter-specific Chromatin Binding
	Biological Process	Inflammatory Response Regulation Of Gene Expression T Cell Receptor Signaling Pathway Positive Regulation Of T-helper 17 Cell Differentiation	Regulation Of Transcription By RNA Polymerase II Mesoderm Development Response To Bacterium B Cell Differentiation T Cell Differentiation Regulation Of B Cell Proliferation B Cell Activation Regulation Of Apoptotic Process Regulation Of B Cell Differentiation Regulation Of Lymphocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS			Acute lymphoblastic leukemia (childhood) ( 29348612) Asthma ( 28461288 31959851 31619474) Asthma (moderate or severe) ( 30552067) Asthma and hay fever ( 24388013) Asthma or allergic disease (pleiotropy) ( 29785011) Asthma with severe exacerbations ( 32841424) Atopic march ( 26542096) Bronchial hyperresponsiveness in asthma ( 27439200) Crohn's disease ( 21102463 28067908) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Inflammatory bowel disease ( 23128233 28067908) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lymphocyte count ( 29403010 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Marginal zone lymphoma or systemic lupus erythematosus ( 31407831) Multiple sclerosis ( 24076602 31604244) Neutrophil percentage of granulocytes ( 27863252) Pediatric autoimmune diseases ( 26301688) Polycystic ovary syndrome ( 30343302) Primary biliary cholangitis ( 20639880 23000144 30643196 28062665 19458352 26394269) Primary biliary cirrhosis ( 22961000) Refractive error ( 32231278) Rheumatoid arthritis ( 24390342 23143596 30423114) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Selective IgA deficiency ( 27723758) Self-reported allergy ( 23817569) Systemic lupus erythematosus ( 27399966 26502338) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 31672989) Type 1 diabetes ( 30659077 25751624) Ulcerative colitis ( 28067908 21297633 20228799)
Interacting Genes		111 interacting genes: ADAMTSL4 AIRIM ANXA11 ARHGEF2 BEX2 C1orf94 CCHCR1 CRYBA2 CTRC CYB5R2 DDX25 DMRT3 DTX3 EFHC2 ELOA ESR2 FAAP20 FAM107A FARS2 FOXI1 GADD45GIP1 GFAP GIGYF1 GLYCTK GPANK1 GRB10 HDAC4 HNRNPF HNRNPH1 HOXA1 HOXB5 HOXC8 HOXC9 HOXD3 HSBP1L1 IHO1 IKZF3 INCA1 IRX6 KICS2 KRT19 KRT34 KRT40 KRT75 KRT76 KRTAP6-2 LCK LGALS14 LHX3 LMO2 LMO3 LMO4 MEOX2 MRPL28 MRPL53 MYEF2 NCK2 NDUFB7 NICN1 NUP54 PATL1 PATZ1 PAX6 PKP1 PLEKHN1 POMC POU4F2 PRDM6 PRMT7 PSMB8 PTCD1 QARS1 RAD51D RBM14 RBM41 RBM4B RFX2 RING1 RSPH1 RTP5 RUNX1 SAMD11 SAMD4A SCNM1 SH2D1B SH3RF1 SLU7 SMAD4 SMG9 SNAPC3 SORBS3 SPMIP2 SS18 SSC4D TCF19 TCF4 TCL1A TEKT4 TEKT5 TFIP11 TRAF2 TRIM29 TRIM9 TRIML2 TSEN54 TSSK3 UTP23 VIM ZBTB16 ZC2HC1B ZIC1	157 interacting genes: ABLIM3 AIRIM AKAP10 AKAP9 ANKS1A AQP1 ARMC7 ARNT2 ATP6V0D1 ATP6V0D2 ATPAF2 ATXN7L2 BCAS2 BCL2L1 BLK BLZF1 BYSL CABP4 CABP5 CARD9 CATSPER1 CATSPERT CCDC102B CCDC187 CCDC24 CCDC57 CCHCR1 CDC37 CDC7 CDK4 CDKN1A CDKN2D CFAP206 CHCHD2 CHD3 CKS1B CLCNKA CRBN CRK CRYBA4 DGCR6 DTX2 EFHC1 EGLN3 EMC2 ENKD1 EXOC8 EXOSC5 FAM124B FANCG FANCL FARS2 FBF1 FHL3 FRS3 GEM GOLGA2 GOLGA6A GRAP2 GRB2 HNRNPF HNRNPLL HOXC8 HRAS IKZF1 IKZF4 IKZF5 ING5 KANK2 KAT5 KIF9 KIFC3 KLHL38 KRT19 LDOC1 LENG1 LGALS14 LMO1 LMO2 LMO4 LNX1 LONRF1 MAD2L2 MAGOHB MCM7 MCRS1 MID2 MISP MKRN3 MORN3 MRPL28 MRPL53 MYO15B NATD1 NEK6 NFKBID NME7 NOS3 NTAQ1 NUDT16L1 NXT2 OAZ3 OSGIN1 PCID2 PDZD4 PFDN5 PIK3R1 PIK3R2 PIN1 POLM POLR1C PPP1R16B PPP1R18 PRDM1 PRKAA1 PRKAA2 PRKAB2 PSMA1 PSMF1 RAD51D RBBP8 RCOR3 RHOA RNF6 RUNX1 SCNM1 SMARCB1 SMARCD1 SPG21 STAMBPL1 STK16 STK26 STX11 SUMO1 TBC1D22B TCAF1 TCAP TCEANC TCHP TEKT3 TEKT4 TFAP2D TLE5 TRAPPC6A TRIM42 TSEN15 TSGA10IP TSSK3 TSTD2 UBE2I USP2 VBP1 YES1 ZGPAT ZMYM2 ZNF587 ZNF76
Entrez ID		84807	22806
HPRD ID		18140	05869
Ensembl ID		ENSG00000167604	ENSG00000161405
Uniprot IDs		A0A286YF31 A0AAQ5BIF9 Q8NI38	Q9UKT9
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II Intermediate Filament Organization Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Nucleus RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of RNA Metabolic Process Intermediate Filament Regulation Of Transcription By RNA Polymerase II Cell Differentiation DNA-binding Transcription Factor Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Structural Constituent Of Skin Epidermis Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Cellular Developmental Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Anterior/posterior Pattern Specification Chromatin Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Speck Neuron Fate Specification Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Pattern Specification Process Regionalization RNA Metabolic Process Sequence-specific Double-stranded DNA Binding Positive Regulation Of Biosynthetic Process Developmental Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cell Fate Specification Positive Regulation Of Macromolecule Metabolic Process Ventral Spinal Cord Interneuron Specification MRNA Splicing, Via Spliceosome Supramolecular Fiber Organization Keratin Filament CD27 Signaling Pathway Embryonic Morphogenesis RNA Splicing, Via Transesterification Reactions Axonemal A Tubule Inner Sheath RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding	Protein Binding Nucleus Centrosome Microtubule-based Process Organelle Organization Cytoplasm Nucleoplasm Phosphotyrosine Residue Binding Cis-Golgi Network AMP-activated Protein Kinase Activity Microtubule Cytoskeleton Organization Lipid Droplet Disassembly Sperm Flagellum Microtubule Cytoskeleton Organization Involved In Mitosis Cytoskeleton Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Plasma Membrane Proton-transporting V-type ATPase Complex Axonemal A Tubule Inner Sheath Phosphatidylethanolamine Biosynthetic Process Protein K6-linked Ubiquitination Positive Regulation Of Lymphocyte Activation Regulation Of Mitotic Cell Cycle Nucleotide-activated Protein Kinase Complex Ephrin Receptor Binding Spindle Organization Microtubule Nucleation Cytoskeleton Organization Motile Cilium Regulation Of Autophagy Cyclin D2-CDK4 Complex Axonemal Microtubule Mitotic Spindle Organization Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Cell Activation Regulation Of Organelle Organization Regulation Of Mitotic Cell Cycle Phase Transition Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Cell Activation Regulation Of Lymphocyte Activation Hepatocyte Apoptotic Process Protein Localization To Lipid Droplet Organelle Assembly Regulation Of Cell Cycle
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