NFKBID and GRB10

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NFKBID	GRB10
Description		NFKB inhibitor delta	growth factor receptor bound protein 10
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Cytoplasm Cytosol Plasma Membrane Protein-containing Complex
	Molecular Function	Protein Binding	Insulin Receptor Binding Protein Binding Signaling Receptor Complex Adaptor Activity Protein-macromolecule Adaptor Activity Identical Protein Binding
	Biological Process	Inflammatory Response Regulation Of Gene Expression T Cell Receptor Signaling Pathway Positive Regulation Of T-helper 17 Cell Differentiation	Signal Transduction Insulin Receptor Signaling Pathway Gene Expression Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Insulin Positive Regulation Of Phosphorylation Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of D-glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway ERK1 And ERK2 Cascade Positive Regulation Of Cold-induced Thermogenesis Vascular Associated Smooth Muscle Cell Migration
Pathways			Signaling by SCF-KIT IRS activation Signal attenuation Insulin receptor signalling cascade RET signaling FLT3 Signaling Response of EIF2AK1 (HRI) to heme deficiency
Drugs
Diseases
GWAS			Acute lymphoblastic leukemia (childhood) ( 23512250) Age-related hearing impairment ( 34108613) Appendicular lean mass ( 33097823) Area under the curve of insulin levels ( 24699409) Birth weight ( 31043758) Blood pressure (smoking interaction) ( 25189868) Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Corpus callosum mid-anterior volume ( 31530798) Corrected insulin response ( 24699409) Corrected insulin response adjusted for insulin sensitivity index ( 24699409) Diastolic blood pressure ( 30224653) Eosinophil count ( 32888494 27863252) Estimated glomerular filtration rate ( 31152163 31015462) Fasting blood glucose ( 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting glucose ( 34059833) Fasting insulin ( 34059833) Femoral neck bone mineral density ( 22504420) Fractures ( 30158200) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Incremental insulin ( 24699409) Insulin levels adjusted for BMI ( 24699409) Insulin-related traits (multivariate analysis) ( 32002517) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Metabolite levels ( 23823483) Morning person ( 30696823) Ratio of the area under the curve for insulin and the area under the curve for glucose ( 24699409) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901) Schizophrenia (treatment resistant) ( 25223841) Subcortical volume (MOSTest) ( 32665545) Sum eosinophil basophil counts ( 27863252) Systemic sclerosis ( 21779181) Total body bone mineral density ( 29304378) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		111 interacting genes: ADAMTSL4 AIRIM ANXA11 ARHGEF2 BEX2 C1orf94 CCHCR1 CRYBA2 CTRC CYB5R2 DDX25 DMRT3 DTX3 EFHC2 ELOA ESR2 FAAP20 FAM107A FARS2 FOXI1 GADD45GIP1 GFAP GIGYF1 GLYCTK GPANK1 GRB10 HDAC4 HNRNPF HNRNPH1 HOXA1 HOXB5 HOXC8 HOXC9 HOXD3 HSBP1L1 IHO1 IKZF3 INCA1 IRX6 KICS2 KRT19 KRT34 KRT40 KRT75 KRT76 KRTAP6-2 LCK LGALS14 LHX3 LMO2 LMO3 LMO4 MEOX2 MRPL28 MRPL53 MYEF2 NCK2 NDUFB7 NICN1 NUP54 PATL1 PATZ1 PAX6 PKP1 PLEKHN1 POMC POU4F2 PRDM6 PRMT7 PSMB8 PTCD1 QARS1 RAD51D RBM14 RBM41 RBM4B RFX2 RING1 RSPH1 RTP5 RUNX1 SAMD11 SAMD4A SCNM1 SH2D1B SH3RF1 SLU7 SMAD4 SMG9 SNAPC3 SORBS3 SPMIP2 SS18 SSC4D TCF19 TCF4 TCL1A TEKT4 TEKT5 TFIP11 TRAF2 TRIM29 TRIM9 TRIML2 TSEN54 TSSK3 UTP23 VIM ZBTB16 ZC2HC1B ZIC1	49 interacting genes: AANAT ABL1 AKT1 APP BAIAP2 BCR BLK CHFR CNOT9 DOK1 EGFR ELK1 EPHB1 ERBB2 ERBB4 FARS2 FYN GHR GIGYF1 GIGYF2 IGF1R INSR IRS1 JAK2 KANK2 KDR KIT KPNA3 MAP2K1 MAP3K14 MAPK1 MEGF10 NEDD4 NFKBID NOA1 PDGFRB PICK1 RAF1 RET SRC TEKT4 TEPSIN TNK1 TRIM55 TRIM63 TXK WEE2-AS1 ZDHHC17 ZMYND19
Entrez ID		84807	2887
HPRD ID		18140	03312
Ensembl ID		ENSG00000167604	ENSG00000106070
Uniprot IDs		A0A286YF31 A0AAQ5BIF9 Q8NI38	A0A2R8YCL1 Q13322
PDB IDs			1NRV 3HK0
Enriched GO Terms of Interacting Partners?		Protein Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II Intermediate Filament Organization Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Nucleus RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of RNA Metabolic Process Intermediate Filament Regulation Of Transcription By RNA Polymerase II Cell Differentiation DNA-binding Transcription Factor Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Structural Constituent Of Skin Epidermis Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Cellular Developmental Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Anterior/posterior Pattern Specification Chromatin Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Speck Neuron Fate Specification Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Pattern Specification Process Regionalization RNA Metabolic Process Sequence-specific Double-stranded DNA Binding Positive Regulation Of Biosynthetic Process Developmental Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cell Fate Specification Positive Regulation Of Macromolecule Metabolic Process Ventral Spinal Cord Interneuron Specification MRNA Splicing, Via Spliceosome Supramolecular Fiber Organization Keratin Filament CD27 Signaling Pathway Embryonic Morphogenesis RNA Splicing, Via Transesterification Reactions Axonemal A Tubule Inner Sheath RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding	Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Kinase Activity Kinase Activity Protein Phosphorylation Phosphorylation Transferase Activity Insulin-like Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Autophosphorylation Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Modification Process Peptidyl-tyrosine Phosphorylation ATP Binding Nucleotide Binding Positive Regulation Of Protein Phosphorylation Positive Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Signal Transduction Response To Growth Factor Positive Regulation Of Phosphorylation Regulation Of Intracellular Signal Transduction ERBB2 Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Phosphorus Metabolic Process Protein Metabolic Process Receptor Complex Regulation Of Signaling Regulation Of Cell Communication Signal Transduction Regulation Of Signal Transduction Regulation Of Protein Modification Process Cellular Response To Growth Factor Stimulus Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Protein Phosphorylation Intracellular Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Cell Migration Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Protein Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Motility
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