PRRC2B and EXOSC1

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		PRRC2B	EXOSC1
Description		proline rich coiled-coil 2B	exosome component 1
Image		No pdb structure
GO Annotations	Cellular Component		Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nucleolar Exosome (RNase Complex)
	Molecular Function	RNA Binding Protein Binding	Nucleic Acid Binding RNA Binding RNA Exonuclease Activity Protein Binding
	Biological Process	Cell Differentiation	RRNA Processing RNA Processing RNA Catabolic Process
Pathways			ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Lung function ( 31902109) Urate levels ( 31578528)	Blood protein levels ( 30072576) Early spontaneous preterm birth ( 31194736) Spontaneous preterm birth with premature rupture of membranes ( 31194736)
Interacting Genes		41 interacting genes: ALG13 ANKHD1 APP ATN1 ATXN1 ATXN1L BAG4 BCAS2 CRK CTBP1 DAPK1 DDX11 DIMT1 DMRTB1 DNAJC5 DPY30 EHMT2 ESS2 EXOSC1 EXOSC4 EXOSC7 FBXO7 IPO5 LSM5 MRPL44 NIP7 NXF1 NXF5 PRPF39 QKI RBFOX2 RBPMS RERE RPL13 SF1 SRPK2 SRSF4 TRNAU1AP TXNL4A YTHDF1 YTHDF3	36 interacting genes: A2M APP ASB9 CDC37 CPSF7 DDIT4L DMRTB1 ECSIT EXOC6 EXOSC4 EXOSC5 EXOSC7 EXOSC8 EXOSC9 FHL3 KCTD1 LNX1 LSM3 MAST1 NOS3 NUP160 PAK5 PRRC2B PTEN RBPMS REL RNF32 SF1 SH3GLB2 TCF4 TEX11 UPF2 WDR83 XRN1 ZNF143 ZNF76
Entrez ID		84726	51013
HPRD ID		13805	16223
Ensembl ID		ENSG00000288701	ENSG00000171311
Uniprot IDs		Q5JSZ5 Q9BU62	B1AMU3 Q9Y3B2
PDB IDs			2NN6 6D6Q 6D6R 6H25 9G8M 9G8N 9G8O 9G8P
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleus RNA Processing RNA Metabolic Process Nucleic Acid Binding RNA Splicing MRNA Metabolic Process Nucleolus MRNA Processing MRNA Binding Nucleoplasm Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Splicing, Via Transesterification Reactions Nucleolar Exosome (RNase Complex) Regulation Of MRNA Metabolic Process Cytoplasmic Stress Granule Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Macromolecule Metabolic Process Regulation Of RNA Splicing Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Regulation Of MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing POZ Domain Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Stress Granule Assembly Negative Regulation Of Macromolecule Metabolic Process MRNA Splice Site Recognition Exoribonuclease Complex Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Spliceosomal Complex Nuclear RNA Export Factor Complex U4 SnRNA 3'-end Processing Protein-RNA Complex Assembly Cytoplasm Transcription Corepressor Activity Negative Regulation Of Metabolic Process Spliceosomal Complex Assembly Memory Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Nuclear MRNA Surveillance Nuclear Inclusion Body N6-methyladenosine-containing RNA Reader Activity	Nuclear MRNA Surveillance Exoribonuclease Complex RRNA Catabolic Process U4 SnRNA 3'-end Processing Nucleolar Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Nuclear RNA Surveillance Nuclear Exosome (RNase Complex) Exosome (RNase Complex) RNA Surveillance SnRNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing SnRNA Processing MRNA Catabolic Process RNA 3'-end Processing MRNA Metabolic Process SnRNA Metabolic Process RNA Catabolic Process Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process MRNA 3'-UTR AU-rich Region Binding 3'-5'-RNA Exonuclease Activity RRNA 3'-end Processing TRNA Decay Nucleobase-containing Compound Catabolic Process RNA Processing RRNA Metabolic Process RNA Binding RRNA Processing Nucleus RNA Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing Protein Binding Macromolecule Catabolic Process Negative Regulation Of Smooth Muscle Cell Proliferation DNA Deamination Negative Regulation Of Gene Expression Histone MRNA Catabolic Process Synapse Maturation Nucleic Acid Metabolic Process Sno(s)RNA Metabolic Process Cytosol Regulation Of Gene Expression P-body Histone MRNA Metabolic Process
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