PRRC2B and SRSF4

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		PRRC2B	SRSF4
Description		proline rich coiled-coil 2B	serine and arginine rich splicing factor 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm Nuclear Speck
	Molecular Function	RNA Binding Protein Binding	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Sequence-specific MRNA Binding
	Biological Process	Cell Differentiation	RNA Splicing, Via Transesterification Reactions Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Response To Insulin Negative Regulation Of MRNA Splicing, Via Spliceosome
Pathways			Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination
Drugs			Artenimol
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Lung function ( 31902109) Urate levels ( 31578528)	Carotid plaque maximum area ( 32469969) Hematocrit ( 32888494) Hemoglobin ( 32888494) Mean area of carotid plaque ( 32469969) Schizophrenia ( 26531332) Tourette syndrome ( 30818990)
Interacting Genes		41 interacting genes: ALG13 ANKHD1 APP ATN1 ATXN1 ATXN1L BAG4 BCAS2 CRK CTBP1 DAPK1 DDX11 DIMT1 DMRTB1 DNAJC5 DPY30 EHMT2 ESS2 EXOSC1 EXOSC4 EXOSC7 FBXO7 IPO5 LSM5 MRPL44 NIP7 NXF1 NXF5 PRPF39 QKI RBFOX2 RBPMS RERE RPL13 SF1 SRPK2 SRSF4 TRNAU1AP TXNL4A YTHDF1 YTHDF3	28 interacting genes: CPSF7 DYRK1A ERAL1 FUS GEMIN2 HAP1 HTATSF1 NXF1 PNN PPARGC1A PRPF38A PRRC2B SART1 SCAF11 SMURF1 SMURF2 SREK1 SRPK1 SRRM2 SRRM4 SRSF10 SRSF2 SRSF6 TICAM1 TRA2B UBE2I USP7 ZDHHC17
Entrez ID		84726	6429
HPRD ID		13805	09052
Ensembl ID		ENSG00000288701	ENSG00000116350
Uniprot IDs		Q5JSZ5 Q9BU62	Q08170
PDB IDs
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleus RNA Processing RNA Metabolic Process Nucleic Acid Binding RNA Splicing MRNA Metabolic Process Nucleolus MRNA Processing MRNA Binding Nucleoplasm Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Splicing, Via Transesterification Reactions Nucleolar Exosome (RNase Complex) Regulation Of MRNA Metabolic Process Cytoplasmic Stress Granule Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Macromolecule Metabolic Process Regulation Of RNA Splicing Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Regulation Of MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing POZ Domain Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Stress Granule Assembly Negative Regulation Of Macromolecule Metabolic Process MRNA Splice Site Recognition Exoribonuclease Complex Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Spliceosomal Complex Nuclear RNA Export Factor Complex U4 SnRNA 3'-end Processing Protein-RNA Complex Assembly Cytoplasm Transcription Corepressor Activity Negative Regulation Of Metabolic Process Spliceosomal Complex Assembly Memory Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Nuclear MRNA Surveillance Nuclear Inclusion Body N6-methyladenosine-containing RNA Reader Activity	RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing RNA Binding RNA Splicing, Via Transesterification Reactions Nuclear Speck RNA Metabolic Process Nucleic Acid Metabolic Process Regulation Of RNA Splicing Spliceosomal Complex Regulation Of MRNA Splicing, Via Spliceosome Nucleoplasm MRNA Splicing, Via Spliceosome Protein-RNA Complex Assembly Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process MRNA Binding Nucleic Acid Binding Regulation Of MRNA Metabolic Process Spliceosomal Complex Assembly Nucleus Protein-containing Complex Assembly Negative Regulation Of MRNA Splicing, Via Spliceosome Protein-containing Complex Organization Negative Regulation Of RNA Splicing Negative Regulation Of MRNA Metabolic Process PML Body Cellular Component Assembly Spliceosomal SnRNP Assembly U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome Pre-mRNA Binding Presynaptic Cytosol Postsynaptic Cytosol Protein Binding Nuclear Export MRNA Splice Site Recognition Wnt Signaling Pathway, Planar Cell Polarity Pathway Histone H3T45 Kinase Activity SUMO Conjugating Enzyme Activity Positive Regulation Of Neurotrophin Production Maturation Of 5S RRNA Perforant Pathway To Dendrate Granule Cell Synapse Engulfment Of Target By Autophagosome Positive Regulation Of RNA Splicing Regulation Of Amyloid-beta Formation
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