PRRC2B and DIMT1

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		PRRC2B	DIMT1
Description		proline rich coiled-coil 2B	DIM1 rRNA methyltransferase and ribosome maturation factor
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm Nucleolus Cytosol Small-subunit Processome
	Molecular Function	RNA Binding Protein Binding	RRNA (adenine-N6,N6-)-dimethyltransferase Activity RNA Binding Methyltransferase Activity Transferase Activity 18S RRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase Activity
	Biological Process	Cell Differentiation	RRNA Modification RRNA Processing RRNA Methylation Methylation Ribosomal Small Subunit Biogenesis Positive Regulation Of RRNA Processing
Pathways			rRNA modification in the nucleus and cytosol
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Lung function ( 31902109) Urate levels ( 31578528)
Interacting Genes		41 interacting genes: ALG13 ANKHD1 APP ATN1 ATXN1 ATXN1L BAG4 BCAS2 CRK CTBP1 DAPK1 DDX11 DIMT1 DMRTB1 DNAJC5 DPY30 EHMT2 ESS2 EXOSC1 EXOSC4 EXOSC7 FBXO7 IPO5 LSM5 MRPL44 NIP7 NXF1 NXF5 PRPF39 QKI RBFOX2 RBPMS RERE RPL13 SF1 SRPK2 SRSF4 TRNAU1AP TXNL4A YTHDF1 YTHDF3	4 interacting genes: APP CEBPA NEDD9 PRRC2B
Entrez ID		84726	27292
HPRD ID		13805	13676
Ensembl ID		ENSG00000288701	ENSG00000086189
Uniprot IDs		Q5JSZ5 Q9BU62	A0A0C4DGB1 A8K9K8 Q9UNQ2
PDB IDs			1ZQ9 6W6C 6W6F 7MQA 7WTS
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleus RNA Processing RNA Metabolic Process Nucleic Acid Binding RNA Splicing MRNA Metabolic Process Nucleolus MRNA Processing MRNA Binding Nucleoplasm Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Splicing, Via Transesterification Reactions Nucleolar Exosome (RNase Complex) Regulation Of MRNA Metabolic Process Cytoplasmic Stress Granule Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Macromolecule Metabolic Process Regulation Of RNA Splicing Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Regulation Of MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing POZ Domain Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Stress Granule Assembly Negative Regulation Of Macromolecule Metabolic Process MRNA Splice Site Recognition Exoribonuclease Complex Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Spliceosomal Complex Nuclear RNA Export Factor Complex U4 SnRNA 3'-end Processing Protein-RNA Complex Assembly Cytoplasm Transcription Corepressor Activity Negative Regulation Of Metabolic Process Spliceosomal Complex Assembly Memory Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Nuclear MRNA Surveillance Nuclear Inclusion Body N6-methyladenosine-containing RNA Reader Activity	Regulation Of Dendritic Spine Maintenance Learning Or Memory Cognition Positive Regulation Of Lymphocyte Migration Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Cell Activation Positive Regulation Of Mononuclear Cell Migration Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Lymphocyte Migration Positive Regulation Of Leukocyte Chemotaxis RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Notch Signaling Pathway Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Inflammatory Response Positive Regulation Of Protein Metabolic Process Positive Regulation Of Chemotaxis Endosome To Plasma Membrane Transport Vesicle Cell Maturation Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Postsynapse Organization Lipoprotein Particle Positive Regulation Of Cell Differentiation Memory Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Cellular Response To Metal Ion Nervous System Process CHOP-C/EBP Complex Response To Vitamin B2 C/EBP Complex Positive Regulation Of Immunological Synapse Formation Positive Regulation Of Proteolysis Positive Regulation Of Immune System Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Developmental Maturation Regulation Of Chemotaxis Positive Regulation Of Protein Catabolic Process Cellular Response To Norepinephrine Stimulus
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