PRRC2B and RERE

Number of citations of the paper that reports this interaction (PubMedID 16713569)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PRRC2B	RERE
Description		proline rich coiled-coil 2B	arginine-glutamic acid dipeptide repeats
Image		No pdb structure
GO Annotations	Cellular Component		Histone Deacetylase Complex Nucleus Nucleoplasm Nuclear Body
	Molecular Function	RNA Binding Protein Binding	Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Cell Differentiation	Chromatin Remodeling Regulation Of DNA-templated Transcription Cerebellum Development Cerebellar Purkinje Cell Layer Maturation Cerebellar Granule Cell Precursor Proliferation Radial Glia Guided Migration Of Purkinje Cell Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Branching Morphogenesis Of A Nerve Dendrite Morphogenesis
Pathways
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Lung function ( 31902109) Urate levels ( 31578528)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergy ( 27182965) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Appendicular lean mass ( 33097823) Asthma ( 34103634 32296059 31619474 31361310 30929738) Asthma (adult onset) ( 30929738) Asthma (moderate or severe) ( 30552067) Asthma and major depressive disorder ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Autoimmune thyroid disease ( 32581359) Body size at age 10 ( 32376654) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Daytime nap ( 33568662) Depression ( 29700475) Diastolic blood pressure ( 27841878) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Feeling miserable ( 29500382) Femoral neck bone mineral density ( 22504420) Fish- and plant-related diet ( 32066663) Glaucoma (primary open-angle) ( 33627673) Heel bone mineral density ( 28869591 30598549) Hippocampal volume in normal cognition ( 29274321) Loneliness ( 31518406) Lymphocyte count ( 32888494 27863252) Major depressive disorder ( 27479909) Medication use (adrenergics, inhalants) ( 31015401) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Optic cup area ( 25631615 28073927) Parkinson's disease ( 32201043) Refractive error ( 32231278) Schizophrenia ( 28991256 29483656 30285260) Smoking initiation ( 30617275 33082346) Smoking status (ever vs never smokers) ( 30643258) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 33536424) Systolic blood pressure ( 30578418) Tonsillectomy ( 28928442 27182965) Total body bone mineral density ( 29304378) Total carotid plaque area (excess vs minimal atherosclerosis) ( 32811377) Upper eyelid morphology ( 29921221) Vertical cup-disc ratio ( 25241763 20548946) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Vitiligo ( 20410501 27723757) White blood cell count ( 32888494 27863252)
Interacting Genes		41 interacting genes: ALG13 ANKHD1 APP ATN1 ATXN1 ATXN1L BAG4 BCAS2 CRK CTBP1 DAPK1 DDX11 DIMT1 DMRTB1 DNAJC5 DPY30 EHMT2 ESS2 EXOSC1 EXOSC4 EXOSC7 FBXO7 IPO5 LSM5 MRPL44 NIP7 NXF1 NXF5 PRPF39 QKI RBFOX2 RBPMS RERE RPL13 SF1 SRPK2 SRSF4 TRNAU1AP TXNL4A YTHDF1 YTHDF3	25 interacting genes: ALG13 ATN1 CBFA2T2 CCDC120 ECM1 EFEMP1 EFEMP2 EHMT2 H3C14 KAT6A KRTAP12-4 KRTAP4-12 KRTAP6-2 LZTR1 NR2E1 PLSCR1 PRRC2A PRRC2B PSMA3 RBFOX2 SNRPC TRIM22 TRIP6 VHL ZMYND8
Entrez ID		84726	473
HPRD ID		13805	05566
Ensembl ID		ENSG00000288701	ENSG00000142599
Uniprot IDs		Q5JSZ5 Q9BU62	Q9P2R6
PDB IDs			2YQK
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleus RNA Processing RNA Metabolic Process Nucleic Acid Binding RNA Splicing MRNA Metabolic Process Nucleolus MRNA Processing MRNA Binding Nucleoplasm Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Splicing, Via Transesterification Reactions Nucleolar Exosome (RNase Complex) Regulation Of MRNA Metabolic Process Cytoplasmic Stress Granule Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Macromolecule Metabolic Process Regulation Of RNA Splicing Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Regulation Of MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing POZ Domain Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Stress Granule Assembly Negative Regulation Of Macromolecule Metabolic Process MRNA Splice Site Recognition Exoribonuclease Complex Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Spliceosomal Complex Nuclear RNA Export Factor Complex U4 SnRNA 3'-end Processing Protein-RNA Complex Assembly Cytoplasm Transcription Corepressor Activity Negative Regulation Of Metabolic Process Spliceosomal Complex Assembly Memory Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Nuclear MRNA Surveillance Nuclear Inclusion Body N6-methyladenosine-containing RNA Reader Activity	Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Nucleoplasm Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Binding Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Transcription Corepressor Activity Negative Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Cajal Body Protein Binding Developmental Process Zinc Ion Binding Camera-type Eye Development Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Extracellular Matrix Structural Constituent Regulation Of Gene Expression Epidermal Growth Factor Receptor Binding Eye Development DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Forebrain Generation Of Neurons Histone H3K56 Methyltransferase Activity Positive Regulation Of Smooth Muscle Cell-matrix Adhesion N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase Activity Endoplasmic Reticulum Tubular Network Maintenance
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