PRRC2B and DDX11

Number of citations: 84 (PubMedID 34133714)
Data Source: BioGRID (two hybrid)

		PRRC2B	DDX11
Name		proline rich coiled-coil 2B	DEAD/H-box helicase 11
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	None	Chromatin Spindle Pole Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Centrosome Cytoskeleton Midbody Mitotic Cohesin Complex Extracellular Exosome
	Molecular Function	RNA Binding Protein Binding	Nucleotide Binding Nucleic Acid Binding DNA Binding DNA Helicase Activity Chromatin Binding DNA Replication Origin Binding Double-stranded DNA Binding Single-stranded DNA Binding RNA Binding Single-stranded RNA Binding Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA ATP-dependent Activity, Acting On RNA Hydrolase Activity Hydrolase Activity, Acting On Acid Anhydrides, In Phosphorus-containing Anhydrides Isomerase Activity ATP Hydrolysis Activity 5'-3' DNA Helicase Activity Triplex DNA Binding Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding G-quadruplex DNA Binding Catalytic Activity, Acting On A Nucleic Acid
	Biological Process	Cell Differentiation	Nucleobase-containing Compound Metabolic Process DNA Replication DNA Repair DNA Damage Response Sister Chromatid Cohesion Replication Fork Processing Negative Regulation Of Protein Binding Establishment Of Sister Chromatid Cohesion Positive Regulation Of Chromatin Binding Positive Regulation Of Sister Chromatid Cohesion Cellular Response To Hydroxyurea Cellular Response To Cisplatin Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Cellular Response To Bleomycin Nucleolar Chromatin Organization Positive Regulation Of Double-strand Break Repair
Pathways		None	XBP1(S) activates chaperone genes
Diseases		None	Warsaw breakage syndrome
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847 ) Lung function ( 31902109 ) Urate levels ( 31578528 )	No GWAS studies recorded
Interacting Genes		41 interacting genes: ALG13 ANKHD1 APP ATN1 ATXN1 ATXN1L BAG4 BCAS2 CRK CTBP1 DAPK1 DDX11 DIMT1 DMRTB1 DNAJC5 DPY30 EHMT2 ESS2 EXOSC1 EXOSC4 EXOSC7 FBXO7 IPO5 LSM5 MRPL44 NIP7 NXF1 NXF5 PRPF39 QKI RBFOX2 RBPMS RERE RPL13 SF1 SRPK2 SRSF4 TRNAU1AP TXNL4A YTHDF1 YTHDF3	4 interacting genes: EIF4ENIF1 KAT7 PFN2 PRRC2B
Entrez ID		84726	1663
HPRD ID		13805	03095
Ensembl ID		ENSG00000288701	ENSG00000013573
Uniprot IDs		Q5JSZ5 Q9BU62	Q2NKM7 Q96FC9
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		RNA Binding Nucleus RNA Processing RNA Metabolic Process Nucleic Acid Binding RNA Splicing MRNA Metabolic Process Nucleolus MRNA Processing MRNA Binding Nucleoplasm Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Splicing, Via Transesterification Reactions Nucleolar Exosome (RNase Complex) Regulation Of MRNA Metabolic Process Cytoplasmic Stress Granule Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Macromolecule Metabolic Process Regulation Of RNA Splicing Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Regulation Of MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing POZ Domain Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Stress Granule Assembly Negative Regulation Of Macromolecule Metabolic Process MRNA Splice Site Recognition Exoribonuclease Complex Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Spliceosomal Complex Nuclear RNA Export Factor Complex U4 SnRNA 3'-end Processing Protein-RNA Complex Assembly Cytoplasm Transcription Corepressor Activity Negative Regulation Of Metabolic Process Spliceosomal Complex Assembly Memory Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Nuclear MRNA Surveillance Nuclear Inclusion Body N6-methyladenosine-containing RNA Reader Activity	Maintenance Of Protein Localization At Cell Tip Histone H3K23 Acetyltransferase Activity Histone H3K4 Acetyltransferase Activity Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Histone H3-K14 Acetyltransferase Complex Response To Dithiothreitol Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Modification Of Postsynaptic Actin Cytoskeleton Presynaptic Actin Cytoskeleton Organization Presynaptic Cytoskeleton Organization Negative Regulation Of Ruffle Assembly Maintenance Of Animal Organ Identity Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Intermediate Filament Binding Regulation Of Ventricular Cardiac Muscle Cell Action Potential Alpha-catenin Binding Cell Tip Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Intermediate Filament Bundle Assembly Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Desmosome Assembly Internal Protein Amino Acid Acetylation Response To Anisomycin Internal Peptidyl-lysine Acetylation DNA Replication-dependent Chromatin Disassembly Response To Hydroxyurea Histone H4K8 Acetyltransferase Activity Histone H4K12 Acetyltransferase Activity Histone H3K14 Acetyltransferase Activity Histone H4K16 Acetyltransferase Activity Response To Sorbitol Histone H3 Acetyltransferase Activity Histone H4K5 Acetyltransferase Activity Response To Actinomycin D Positive Regulation Of Hematopoietic Stem Cell Proliferation Histone H4 Acetyltransferase Activity Nuclear Export Signal Receptor Activity Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Peptidyl-lysine Acetylation Negative Regulation Of Epithelial Cell Migration Regulation Of Actin Filament-based Process Desmosome Organization Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of DNA-templated DNA Replication Initiation DNA Replication Origin Binding P-body Assembly Ventricular Cardiac Muscle Cell Action Potential Regulation Of Hematopoietic Stem Cell Proliferation Natural Killer Cell Differentiation Modification Of Postsynaptic Structure