PDE3B and ANKRA2

Number of citations of the paper that reports this interaction (PubMedID 22649097)
0

Data Source:
BioGRID (unspecified method)

		PDE3B	ANKRA2
Description		phosphodiesterase 3B	ankyrin repeat family A member 2
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Golgi Apparatus Cytosol Membrane Guanyl-nucleotide Exchange Factor Complex	Nucleus Cytoplasm Cytosol Cytoskeleton Membrane Protein-containing Complex 3M Complex
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Protein Kinase B Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	Protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Histone Deacetylase Binding Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Angiogenesis Negative Regulation Of Cell Adhesion Signal Transduction G Protein-coupled Receptor Signaling Pathway Insulin Receptor Signaling Pathway Negative Regulation Of Angiogenesis Negative Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Angiogenesis Negative Regulation Of Lipid Catabolic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of CAMP/PKA Signal Transduction	Regulation Of Gene Expression Regulation Of Protein-containing Complex Assembly
Pathways		PDE3B signalling PDE3B signalling G alpha (s) signalling events
Drugs		Caffeine Caffeine Papaverine Amrinone 6-(4-{[2-(3-iodobenzyl)-3-oxocyclohex-1-en-1-yl]amino}phenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one Hg9a-9, Nonanoyl-N-Hydroxyethylglucamide 3-isobutyl-1-methyl-7H-xanthine Trapidil
Diseases
GWAS		Adiponectin levels ( 31178129) Bipolar disorder ( 31043756) Femur bone mineral density x serum urate levels interaction ( 34046847) HDL cholesterol ( 30275531) High density lipoprotein cholesterol levels ( 29083408) High light scatter reticulocyte count ( 32888494) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Mean spheric corpuscular volume ( 32888494) Multiple sclerosis ( 31604244) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum 25-Hydroxyvitamin D levels ( 31841498) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Type 2 diabetes ( 30297969) Vitamin D levels ( 25208829) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for body mass index ( 28430825)	Monobrow thickness ( 26926045)
Interacting Genes		7 interacting genes: AKT1 ANKRA2 HPGDS LNX1 PRKACA YWHAB YWHAQ	13 interacting genes: ABL1 APP CDKN2A HDAC4 HDAC5 HDAC9 LRP2 MPL NEK6 PDE3B RFX7 SAMD4A TSHZ3
Entrez ID		5140	57763
HPRD ID		03626	12044
Ensembl ID		ENSG00000152270	ENSG00000164331
Uniprot IDs		A7E2E5 Q13370	Q9H9E1
PDB IDs		1SO2 1SOJ 8SYC	3SO8 3V2O 3V2X 3V31 4LG6 4QQI 8CXG 8CXH 8CXI
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Vascular Endothelial Cell Response To Fluid Shear Stress Response To Laminar Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Positive Regulation Of Cholesterol Biosynthetic Process Protein Serine/threonine/tyrosine Kinase Activity Postsynapse Positive Regulation Of Cholesterol Metabolic Process Cellular Response To Fluid Shear Stress 14-3-3 Protein Binding Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Steroid Biosynthetic Process Protein Domain Specific Binding Peptidyl-serine Phosphorylation Protein-containing Complex Positive Regulation Of Steroid Metabolic Process Response To Fluid Shear Stress Positive Regulation Of Glucose Metabolic Process Regulation Of Cholesterol Metabolic Process Regulation Of Protein Maturation TORC1 Signaling Negative Regulation Of TORC1 Signaling Regulation Of TRNA Methylation Regulation Of Monoatomic Ion Transport Regulation Of Steroid Biosynthetic Process TOR Signaling Negative Regulation Of Transport Response To Heat Negative Regulation Of TOR Signaling Protein Kinase Binding Regulation Of TORC1 Signaling Regulation Of Glucose Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Regulation Of Steroid Metabolic Process Negative Regulation Of Protein Localization To Lysosome Positive Regulation Of Protein Localization To Endoplasmic Reticulum Regulation Of Cellular Localization Establishment Of Protein Localization Response To Insulin-like Growth Factor Stimulus Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Mammalian Oogenesis Stage Negative Regulation Of Small Molecule Metabolic Process TRNA (guanine-N7)-methylation Cellular Response To Rapamycin Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Endodeoxyribonuclease Activity Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Transmembrane Transport Regulation Of Nucleocytoplasmic Transport	Histone Deacetylase Activity, Hydrolytic Mechanism Protein Lysine Deacetylase Activity Histone Deacetylase Activity B Cell Differentiation Negative Regulation Of Metabolic Process Protein Kinase C Binding Mononuclear Cell Differentiation Leukocyte Activation Cell Activation Regulation Of Myotube Differentiation Histone Deacetylase Complex Regulation Of Cell Differentiation Leukocyte Differentiation Regulation Of Cell Migration Involved In Sprouting Angiogenesis DNA-binding Transcription Factor Binding Regulation Of Primary Metabolic Process Mitochondrial Depolarization B Cell Activation RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Developmental Process Lymphocyte Activation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Type II Interferon Production Negative Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Macromolecule Metabolic Process Lymphocyte Differentiation Negative Regulation Of Long-term Synaptic Potentiation Regulation Of RNA Metabolic Process Positive Regulation Of Protein Sumoylation Regulation Of Striated Muscle Cell Differentiation Epigenetic Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Catecholamine Stimulus Negative Regulation Of Myotube Differentiation Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Type II Interferon Production Regulation Of Multicellular Organismal Process Response To Catecholamine Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Superoxide Anion Generation SUMO Transferase Activity Regulation Of Metabolic Process Regulation Of Superoxide Anion Generation Negative Regulation Of Biosynthetic Process Endosome Lumen Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Gene Expression
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