PDE3B and HPGDS

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PDE3B	HPGDS
Description		phosphodiesterase 3B	hematopoietic prostaglandin D synthase
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GO Annotations	Cellular Component	Endoplasmic Reticulum Golgi Apparatus Cytosol Membrane Guanyl-nucleotide Exchange Factor Complex	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Protein Kinase B Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	Magnesium Ion Binding Glutathione Transferase Activity Prostaglandin-D Synthase Activity Calcium Ion Binding Protein Binding Transferase Activity Isomerase Activity Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Angiogenesis Negative Regulation Of Cell Adhesion Signal Transduction G Protein-coupled Receptor Signaling Pathway Insulin Receptor Signaling Pathway Negative Regulation Of Angiogenesis Negative Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Angiogenesis Negative Regulation Of Lipid Catabolic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of CAMP/PKA Signal Transduction	Prostaglandin Biosynthetic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Prostaglandin Metabolic Process Glutathione Metabolic Process Signal Transduction Locomotory Behavior Response To Nematode Response To Selenium Ion Negative Regulation Of Male Germ Cell Proliferation
Pathways		PDE3B signalling PDE3B signalling G alpha (s) signalling events	Glutathione conjugation Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Drugs		Caffeine Caffeine Papaverine Amrinone 6-(4-{[2-(3-iodobenzyl)-3-oxocyclohex-1-en-1-yl]amino}phenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one Hg9a-9, Nonanoyl-N-Hydroxyethylglucamide 3-isobutyl-1-methyl-7H-xanthine Trapidil	Glutathione Tretinoin 2-(2f-Benzothiazolyl)-5-Styryl-3-(4f-Phthalhydrazidyl)Tetrazolium Chloride Glutathione disulfide Deoxycholic acid 3-phenyl-5-(1H-pyrazol-3-yl)isoxazole PHENYL-5-(1H-PYRAZOL-3-YL)-1,3-THIAZOLE Tranilast 4-{[4-(4-fluoro-3-methylphenyl)-1,3-thiazol-2-yl]amino}-2-hydroxybenzoic acid 4-(BENZHYDRYLOXY)-1-[3-(1H-TETRAAZOL-5-YL)PROPYL]PIPERIDINE Nocodazole 3-(4-nitrophenyl)-1H-pyrazole 1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID
Diseases
GWAS		Adiponectin levels ( 31178129) Bipolar disorder ( 31043756) Femur bone mineral density x serum urate levels interaction ( 34046847) HDL cholesterol ( 30275531) High density lipoprotein cholesterol levels ( 29083408) High light scatter reticulocyte count ( 32888494) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Mean spheric corpuscular volume ( 32888494) Multiple sclerosis ( 31604244) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum 25-Hydroxyvitamin D levels ( 31841498) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Type 2 diabetes ( 30297969) Vitamin D levels ( 25208829) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for body mass index ( 28430825)	Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Blood protein levels ( 30072576) Testicular germ cell tumor ( 23666239 28604728 28604732)
Interacting Genes		7 interacting genes: AKT1 ANKRA2 HPGDS LNX1 PRKACA YWHAB YWHAQ	7 interacting genes: ABHD17A ARRDC3 C14orf39 HK3 LIF MELTF PDE3B
Entrez ID		5140	27306
HPRD ID		03626	04001
Ensembl ID		ENSG00000152270	ENSG00000163106
Uniprot IDs		A7E2E5 Q13370	A0A384P5J0 O60760
PDB IDs		1SO2 1SOJ 8SYC	1IYH 1IYI 1V40 2CVD 2VCQ 2VCW 2VCX 2VCZ 2VD0 2VD1 3EE2 3KXO 3VI5 3VI7 4EC0 4EDY 4EDZ 4EE0 5AIS 5AIV 5AIX 5YWE 5YWX 5YX1 6N4E 6W58 6W8H 6ZTC 7JR6 7JR8
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Vascular Endothelial Cell Response To Fluid Shear Stress Response To Laminar Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Positive Regulation Of Cholesterol Biosynthetic Process Protein Serine/threonine/tyrosine Kinase Activity Postsynapse Positive Regulation Of Cholesterol Metabolic Process Cellular Response To Fluid Shear Stress 14-3-3 Protein Binding Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Steroid Biosynthetic Process Protein Domain Specific Binding Peptidyl-serine Phosphorylation Protein-containing Complex Positive Regulation Of Steroid Metabolic Process Response To Fluid Shear Stress Positive Regulation Of Glucose Metabolic Process Regulation Of Cholesterol Metabolic Process Regulation Of Protein Maturation TORC1 Signaling Negative Regulation Of TORC1 Signaling Regulation Of TRNA Methylation Regulation Of Monoatomic Ion Transport Regulation Of Steroid Biosynthetic Process TOR Signaling Negative Regulation Of Transport Response To Heat Negative Regulation Of TOR Signaling Protein Kinase Binding Regulation Of TORC1 Signaling Regulation Of Glucose Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Regulation Of Steroid Metabolic Process Negative Regulation Of Protein Localization To Lysosome Positive Regulation Of Protein Localization To Endoplasmic Reticulum Regulation Of Cellular Localization Establishment Of Protein Localization Response To Insulin-like Growth Factor Stimulus Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Mammalian Oogenesis Stage Negative Regulation Of Small Molecule Metabolic Process TRNA (guanine-N7)-methylation Cellular Response To Rapamycin Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Endodeoxyribonuclease Activity Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Transmembrane Transport Regulation Of Nucleocytoplasmic Transport	Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Heat Generation Hexokinase Activity Mannokinase Activity Glucokinase Activity Fructokinase Activity Leukemia Inhibitory Factor Signaling Pathway Leukemia Inhibitory Factor Receptor Binding Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Locomotion Involved In Locomotory Behavior Beta-3 Adrenergic Receptor Binding Negative Regulation Of Protein Localization To Microtubule Meiotic DNA Double-strand Break Processing Involved In Reciprocal Meiotic Recombination Meiotic DNA Double-strand Break Processing Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Postsynaptic Recycling Endosome Membrane Protein Depalmitoylation Positive Regulation Of Protein Metabolic Process Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Regulation Of Cell Adhesion Muscle Organ Morphogenesis Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Lung Lobe Morphogenesis Positive Regulation Of Plasminogen Activation Guanyl-nucleotide Exchange Factor Complex Regulation Of Locomotion Involved In Locomotory Behavior Heat Generation Central Element
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