SORBS2 and ACTN4

Number of citations of the paper that reports this interaction (PubMedID 25910212)
47

Data Source:
BioGRID (two hybrid)

		SORBS2	ACTN4
Description		sorbin and SH3 domain containing 2	actinin alpha 4
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Apical Plasma Membrane Z Disc Lamellipodium Dendrite Cell Projection Neuronal Cell Body Synapse Perinuclear Region Of Cytoplasm Anchoring Junction	Stress Fiber Extracellular Region Extracellular Space Nucleus Cytoplasm Cytoskeleton Plasma Membrane Focal Adhesion Actin Cytoskeleton Z Disc Cell Junction Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Protein-containing Complex Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome Anchoring Junction Postsynaptic Actin Cytoskeleton Ribonucleoprotein Complex
	Molecular Function	RNA Binding Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Anchor Activity Structural Constituent Of Muscle Identical Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Nucleoside Binding Transcription Coactivator Activity RNA Binding Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Nuclear Receptor Binding Chromatin DNA Binding Identical Protein Binding Protein Homodimerization Activity Nuclear Retinoic Acid Receptor Binding Transmembrane Transporter Binding Metal Ion Binding Actin Filament Binding
	Biological Process	Cytoskeleton Organization Notch Signaling Pathway Cell Growth Involved In Cardiac Muscle Cell Development	Protein Transport Actin Cytoskeleton Organization Vesicle Transport Along Actin Filament Positive Regulation Of Cell Migration Positive Regulation Of Sodium:proton Antiporter Activity Tumor Necrosis Factor-mediated Signaling Pathway Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Muscle Cell Development Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways			Platelet degranulation Nephrin family interactions
Drugs
Diseases			Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS		Cardiac Troponin-T levels ( 31014085) Coronary artery disease ( 33020668) Cytokine and corticosteroid-stimulated IL-6 production ( 25896417) Cytokine-stimulated IL-6 production ( 25896417) Height ( 31562340) LDL cholesterol levels in HIV infection ( 33109212) Short-term memory (digit-span task) ( 30741946) Triglyceride levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429) Uterine fibroid size (maximum volume) ( 30196971) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Brain morphology (MOSTest) ( 32665545) Fasting glucose ( 34074324) Heart rate ( 23583979) Immature fraction of reticulocytes ( 32888494) Logical memory (immediate recall) in mild cognitive impairment ( 29274321) Mean platelet volume ( 32888494) Retinal venular tortuosity ( 31597446) Waist circumference ( 28552196)
Interacting Genes		46 interacting genes: ABI1 ABL1 ABL2 ACTN1 ACTN4 ADAM15 AFDN AKT1 AKT2 ATPAF2 CBL CBLB DLGAP1 DLGAP2 DLGAP4 EFS EGFR EIF3H FAT1 FLOT1 GOLGA2 MDM2 NCK2 NR1H2 PAK1 PAK2 PALLD PKM PTK2B PTPN12 RPL9 SEMA6A SH2D4A SH3RF1 SHANK3 SOCS7 SYNJ1 TEPSIN TRAF4 VCL VPS37C WAS WASF1 WASL YWHAE YWHAZ	60 interacting genes: ACTC1 ACTN3 ADORA2A ATP6V1B1 ATXN7 BMP7 C14orf119 CAMK2A CAMK2B CAMK2G CDKN2A CEBPA COIL COL17A1 DDIAS DSCAM DSCR9 ESR1 GSN HDAC7 HSPB1 INO80 ITGB1 KPNA2 LCMT2 LNX1 LRRC7 MAGI1 MAPK7 MEF2A MEOX2 MICALL2 MYOZ1 MYOZ2 NEB NHERF2 NOS2 NOS3 PDE4B PDLIM1 POT1 PTGER4 PTPN11 PTPN6 RARA RNF10 RPS27 SACS SERPINE1 SLC2A4 SORBS2 STAT1 TJP1 TRIM23 TRIM3 TTN TXN UCHL5 USP6NL VDR
Entrez ID		8470	81
HPRD ID		12473	05222
Ensembl ID		ENSG00000154556	ENSG00000130402
Uniprot IDs		A0A8Q3WKF2 A0A8Q3WKH1 A0A8Q3WKK4 B7Z3D7 B7Z997 O94875	A0A0S2Z3G9 F5GXS2 H7C144 O43707
PDB IDs		5VEI	1WLX 1YDI 2R0O 6O31 6OA6
Enriched GO Terms of Interacting Partners?		Focal Adhesion Cytosol Lamellipodium Regulation Of Cell Motility SH3 Domain Binding Regulation Of Locomotion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Glutamatergic Synapse Regulation Of Cell Migration Cell-cell Junction Anchoring Junction Cadherin Binding Regulation Of Cellular Component Organization Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Cytoplasm Postsynaptic Density Actin Cytoskeleton Cellular Response To Growth Factor Stimulus ERBB Signaling Pathway Cell Migration Plasma Membrane Intracellular Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Response To Growth Factor Phosphotyrosine Residue Binding Regulation Of Signal Transduction Positive Regulation Of Cell Migration Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Motility Actin Polymerization Or Depolymerization Cell Surface Receptor Signaling Pathway Positive Regulation Of Locomotion Signal Transduction Cell Motility Actin Filament Organization Negative Regulation Of Signal Transduction Regulation Of Actin Filament Organization Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Positive Regulation Of Cellular Component Organization Regulation Of Cell Adhesion Negative Regulation Of Signaling Regulation Of Lymphocyte Migration Developmental Process Negative Regulation Of Cell Communication Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cytoskeleton Organization	Z Disc Actomyosin Structure Organization Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Development Positive Regulation Of Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Multicellular Organismal Process Calmodulin Binding Actin Cytoskeleton Organization Actin Cytoskeleton Positive Regulation Of Metabolic Process Developmental Process Cytoplasm Actin Filament-based Process Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Calcium- And Calmodulin-dependent Protein Kinase Complex Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Calcium-mediated Signaling Regulation Of Macromolecule Biosynthetic Process Telethonin Binding Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Intracellular Signal Transduction Regulation Of Developmental Process Regulation Of Signaling Regulation Of Cell Communication Myofibril Assembly Protein Kinase Binding Anatomical Structure Formation Involved In Morphogenesis Cytoskeleton Organization Actin Binding Anatomical Structure Morphogenesis Regulation Of Skeletal Muscle Adaptation Supramolecular Fiber Organization Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Calcineurin-mediated Signaling Positive Regulation Of Cytokine Production Sarcomere Organization Regulation Of Calcium Ion Transport Actinin Binding Circulatory System Process Structural Constituent Of Muscle Regulation Of Angiogenesis Cardiac Myofibril Assembly Alpha-actinin Binding Negative Regulation Of Developmental Process
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