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SORBS2 and PAK2
Number of citations of the paper that reports this interaction (PMID
16374509
)
26
Data Source:
HPRD
(in vitro)
SORBS2
PAK2
Gene Name
sorbin and SH3 domain containing 2
p21 protein (Cdc42/Rac)-activated kinase 2
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Plasma Membrane
Actin Cytoskeleton
Z Disc
Perinuclear Region Of Cytoplasm
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Perinuclear Region Of Cytoplasm
Molecular Function
Structural Constituent Of Cytoskeleton
Protein Binding
Cytoskeletal Adaptor Activity
Structural Constituent Of Muscle
Protein Domain Specific Binding
Poly(A) RNA Binding
Metal Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Receptor Signaling Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Kinase Binding
Protein Tyrosine Kinase Activator Activity
Identical Protein Binding
Biological Process
Actin Filament Organization
Cell Adhesion
Biological_process
Cell Migration
Mitotic Cell Cycle
Protein Phosphorylation
Negative Regulation Of Protein Kinase Activity
Apoptotic Process
Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
Signal Transduction
Axon Guidance
Viral Process
Phosphorylation
Peptidyl-serine Phosphorylation
Signal Transduction By Phosphorylation
T Cell Costimulation
Intracellular Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Regulation Of Growth
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Innate Immune Response
Protein Autophosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of Defense Response To Virus By Virus
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
T Cell Receptor Signaling Pathway
Positive Regulation Of Protein Tyrosine Kinase Activity
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Pathways
Regulation of PAK-2p34 activity by PS-GAP/RHG10
Costimulation by the CD28 family
Axon guidance
HIV Infection
FCERI mediated MAPK activation
VEGFA-VEGFR2 Pathway
Nef and signal transduction
Ephrin signaling
Activation of Rac
VEGFR2 mediated vascular permeability
Programmed Cell Death
EPH-Ephrin signaling
Innate Immune System
Generation of second messenger molecules
Semaphorin interactions
Apoptotic execution phase
CD28 co-stimulation
Regulation of activated PAK-2p34 by proteasome mediated degradation
Host Interactions of HIV factors
The role of Nef in HIV-1 replication and disease pathogenesis
CD28 dependent Vav1 pathway
Stimulation of the cell death response by PAK-2p34
TCR signaling
Signaling by VEGF
Sema3A PAK dependent Axon repulsion
Fc epsilon receptor (FCERI) signaling
Signaling by Robo receptor
Regulation of Apoptosis
Adaptive Immune System
Drugs
Diseases
GWAS
Visceral adipose tissue/subcutaneous adipose tissue ratio (
22589738
)
Total ventricular volume (
21116278
)
Protein-Protein Interactions
35 interactors:
ABL1
ABL2
ACTN1
ADAM15
AKT1
AKT2
ATPAF2
CBL
DLGAP1
DLGAP2
DLGAP4
EFS
EGFR
FLOT1
MDM2
MLLT4
NCK2
NR1H2
PAK1
PAK2
PALLD
PKM
PTK2B
PTPN12
RPL9
SEMA6A
SH2D4A
SYNJ1
TRAF4
VCL
VPS37C
WAS
WASF1
YWHAE
YWHAZ
51 interactors:
ABI1
ABI3
ABL1
APP
ARHGAP10
ARHGEF6
ARHGEF7
BRAF
CASP3
CDC42
DOCK2
DST
EIF4B
EIF4G1
EP300
FYN
GRB2
HCK
HIST1H4F
LCK
LIMK1
LYN
MAPK1
MAPK3
MKNK1
MYC
MYL2
MYLK
NCK1
NPHP1
PACSIN3
RAC1
RAC2
RAF1
RHOJ
RIOK3
RPS6
SH3GL2
SH3KBP1
SH3PXD2A
SH3RF1
SH3RF3
SNX33
SNX9
SORBS1
SORBS2
SORBS3
SRC
SYN1
VIM
YES1
Entrez ID
8470
5062
HPRD ID
12473
05428
Ensembl ID
ENSG00000154556
ENSG00000180370
Uniprot IDs
B7Z3D7
B7Z997
O94875
A8K5M4
Q13177
PDB IDs
4IGZ
3PCS
Enriched GO Terms of Interacting Partners
?
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of Cellular Component Movement
Signaling
Positive Regulation Of Transport
Cell Communication
Positive Regulation Of Organelle Organization
Programmed Cell Death
Regulation Of Cell Motility
Cell Death
Death
Protein Autophosphorylation
Regulation Of Cellular Component Organization
Cell Activation
Regulation Of Locomotion
Regulation Of Cellular Ketone Metabolic Process
Regulation Of Organelle Organization
Positive Regulation Of Intracellular Transport
Regulation Of Signaling
Axonogenesis
Cell Morphogenesis Involved In Differentiation
Regulation Of Catalytic Activity
Cellular Localization
Regulation Of Signal Transduction
Apoptotic Process
Regulation Of Oxidoreductase Activity
Cell Development
Axon Development
Positive Regulation Of Signal Transduction
Fc Receptor Signaling Pathway
Cell Morphogenesis Involved In Neuron Differentiation
Regulation Of Cellular Localization
Regulation Of Intracellular Transport
Neuron Projection Development
Innate Immune Response
Actin Filament Organization
Neuron Projection Morphogenesis
Neurogenesis
Positive Regulation Of Oxidoreductase Activity
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of Establishment Of Protein Localization
Cell Projection Organization
Regulation Of Apoptotic Process
Regulation Of Phosphorus Metabolic Process
Cell Adhesion
Movement Of Cell Or Subcellular Component
Neuron Development
Regulation Of Actin Cytoskeleton Organization
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Endocytosis
Movement Of Cell Or Subcellular Component
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Fc Receptor Mediated Stimulatory Signaling Pathway
Fc-gamma Receptor Signaling Pathway
Fc Receptor Signaling Pathway
Regulation Of Cellular Component Organization
Axon Guidance
Cell Surface Receptor Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Locomotion
Cytoskeleton Organization
Chemotaxis
Phagocytosis
Axonogenesis
Neurotrophin TRK Receptor Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Immune Response-regulating Signaling Pathway
ERBB Signaling Pathway
Axon Development
Cellular Response To Peptide Hormone Stimulus
Cell Morphogenesis Involved In Neuron Differentiation
Cell Morphogenesis Involved In Differentiation
Cellular Response To Peptide
Cell Projection Organization
Actin Filament-based Process
Neuron Projection Morphogenesis
Signal Transduction
Signaling
Response To Peptide Hormone
Peptidyl-tyrosine Autophosphorylation
Cell Communication
Innate Immune Response
Cellular Response To Organonitrogen Compound
Cell Development
Cellular Response To Growth Factor Stimulus
Apoptotic Process
Response To Peptide
Intracellular Signal Transduction
Actin Cytoskeleton Organization
Cell Projection Morphogenesis
Regulation Of Immune System Process
Cellular Response To Organic Substance
Response To Growth Factor
Cell Part Morphogenesis
Programmed Cell Death
Tagcloud
?
cot
densitometry
erk2
hog
immunoreactivities
jnks
kinases
mapkapk2
mapks
mek1
mekkl
mkk3
mlk3
mos
myocytes
pakl
phenomena
probed
proliferate
proto
raf1
rafb
resist
rsk1
rsk2
sekl
tpl
ventricle
ventricles
Tagcloud (Difference)
?
cot
densitometry
erk2
hog
immunoreactivities
jnks
kinases
mapkapk2
mapks
mek1
mekkl
mkk3
mlk3
mos
myocytes
pakl
phenomena
probed
proliferate
proto
raf1
rafb
resist
rsk1
rsk2
sekl
tpl
ventricle
ventricles
Tagcloud (Intersection)
?