SORBS2 and DYNC1H1

		SORBS2	DYNC1H1
Description		sorbin and SH3 domain containing 2	dynein cytoplasmic 1 heavy chain 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Apical Plasma Membrane Z Disc Lamellipodium Dendrite Cell Projection Neuronal Cell Body Synapse Perinuclear Region Of Cytoplasm Anchoring Junction	Extracellular Region Cytoplasm Centrosome Cytosol Cytoskeleton Cytoplasmic Dynein Complex Microtubule Cytoplasmic Microtubule Cell Cortex Membrane Filopodium Dynein Complex Azurophil Granule Lumen Extracellular Exosome Axon Cytoplasm
	Molecular Function	RNA Binding Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Anchor Activity Structural Constituent Of Muscle Identical Protein Binding	Nucleotide Binding RNA Binding Protein Binding ATP Binding Minus-end-directed Microtubule Motor Activity Identical Protein Binding Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding
	Biological Process	Cytoskeleton Organization Notch Signaling Pathway Cell Growth Involved In Cardiac Muscle Cell Development	Microtubule-based Movement Mitotic Spindle Organization Nuclear Migration Retrograde Axonal Transport Cytoplasmic Microtubule Organization Positive Regulation Of Intracellular Transport P-body Assembly Stress Granule Assembly Establishment Of Spindle Localization Cell Division Regulation Of Mitotic Spindle Organization Regulation Of Metaphase Plate Congression Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Spindle Assembly
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs
Diseases			Distal hereditary motor neuropathies (dHMN)
GWAS		Cardiac Troponin-T levels ( 31014085) Coronary artery disease ( 33020668) Cytokine and corticosteroid-stimulated IL-6 production ( 25896417) Cytokine-stimulated IL-6 production ( 25896417) Height ( 31562340) LDL cholesterol levels in HIV infection ( 33109212) Short-term memory (digit-span task) ( 30741946) Triglyceride levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429) Uterine fibroid size (maximum volume) ( 30196971) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143)
Interacting Genes		46 interacting genes: ABI1 ABL1 ABL2 ACTN1 ACTN4 ADAM15 AFDN AKT1 AKT2 ATPAF2 CBL CBLB DLGAP1 DLGAP2 DLGAP4 EFS EGFR EIF3H FAT1 FLOT1 GOLGA2 MDM2 NCK2 NR1H2 PAK1 PAK2 PALLD PKM PTK2B PTPN12 RPL9 SEMA6A SH2D4A SH3RF1 SHANK3 SOCS7 SYNJ1 TEPSIN TRAF4 VCL VPS37C WAS WASF1 WASL YWHAE YWHAZ	25 interacting genes: BRCA1 BTG3 CEBPA COX20 DISC1 DSCAM DSCR9 DUX4 DYNLL1 EGFR FILNC1 ITSN1 KATNA1 KATNB1 LINC01554 MTNR1B NDEL1 PRKCD RHBDD2 SMAD2 SUMO2 TENT5A TNIK YWHAG YWHAQ
Entrez ID		8470	1778
HPRD ID		12473	02524
Ensembl ID		ENSG00000154556	ENSG00000197102
Uniprot IDs		A0A8Q3WKF2 A0A8Q3WKH1 A0A8Q3WKK4 B7Z3D7 B7Z997 O94875	Q14204
PDB IDs		5VEI	5NUG 5OWO 6F1T 6F1U 6F1V 6F1Y 6F38 6F3A 7Z8F 7Z8G 7Z8H 7Z8I 7Z8J 7Z8K 7Z8L 8DYU 8DYV 8FCY 8FD6 8FDT 8FDU 8PQV 8PQW 8PQY 8PQZ 8PR0 8PR1 8PR2 8PR3 8PTK
Enriched GO Terms of Interacting Partners?		Focal Adhesion Cytosol Lamellipodium Regulation Of Cell Motility SH3 Domain Binding Regulation Of Locomotion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Glutamatergic Synapse Regulation Of Cell Migration Cell-cell Junction Anchoring Junction Cadherin Binding Regulation Of Cellular Component Organization Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Cytoplasm Postsynaptic Density Actin Cytoskeleton Cellular Response To Growth Factor Stimulus ERBB Signaling Pathway Cell Migration Plasma Membrane Intracellular Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Response To Growth Factor Phosphotyrosine Residue Binding Regulation Of Signal Transduction Positive Regulation Of Cell Migration Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Motility Actin Polymerization Or Depolymerization Cell Surface Receptor Signaling Pathway Positive Regulation Of Locomotion Signal Transduction Cell Motility Actin Filament Organization Negative Regulation Of Signal Transduction Regulation Of Actin Filament Organization Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Positive Regulation Of Cellular Component Organization Regulation Of Cell Adhesion Negative Regulation Of Signaling Regulation Of Lymphocyte Migration Developmental Process Negative Regulation Of Cell Communication Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cytoskeleton Organization	Intracellular Signal Transduction DNA Strand Resection Involved In Replication Fork Processing BRCA1-C Complex Cerebral Cortex Cell Migration Katanin Complex Radial Glia-guided Pyramidal Neuron Migration Telencephalon Cell Migration Signal Transduction Forebrain Cell Migration Microtubule Severing
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