SORBS2

Description		sorbin and SH3 domain containing 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Apical Plasma Membrane Z Disc Lamellipodium Dendrite Cell Projection Neuronal Cell Body Synapse Perinuclear Region Of Cytoplasm Anchoring Junction
	Molecular Function	RNA Binding Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Anchor Activity Structural Constituent Of Muscle Identical Protein Binding
	Biological Process	Cytoskeleton Organization Notch Signaling Pathway Cell Growth Involved In Cardiac Muscle Cell Development
Pathways
Drugs
Diseases
GWAS		Cardiac Troponin-T levels ( 31014085) Coronary artery disease ( 33020668) Cytokine and corticosteroid-stimulated IL-6 production ( 25896417) Cytokine-stimulated IL-6 production ( 25896417) Height ( 31562340) LDL cholesterol levels in HIV infection ( 33109212) Short-term memory (digit-span task) ( 30741946) Triglyceride levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429) Uterine fibroid size (maximum volume) ( 30196971) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Novel Interacting Genes		1 novel interacting genes: DYNC1H1
Interacting Genes		46 interacting genes: ABI1 ABL1 ABL2 ACTN1 ACTN4 ADAM15 AFDN AKT1 AKT2 ATPAF2 CBL CBLB DLGAP1 DLGAP2 DLGAP4 EFS EGFR EIF3H FAT1 FLOT1 GOLGA2 MDM2 NCK2 NR1H2 PAK1 PAK2 PALLD PKM PTK2B PTPN12 RPL9 SEMA6A SH2D4A SH3RF1 SHANK3 SOCS7 SYNJ1 TEPSIN TRAF4 VCL VPS37C WAS WASF1 WASL YWHAE YWHAZ
Entrez ID		8470
HPRD ID		12473
Ensembl ID		ENSG00000154556
Uniprot IDs		A0A8Q3WKF2 A0A8Q3WKH1 A0A8Q3WKK4 B7Z3D7 B7Z997 O94875
PDB IDs		5VEI
Enriched GO Terms of Interacting Partners?		Focal Adhesion Cytosol Lamellipodium Regulation Of Cell Motility SH3 Domain Binding Regulation Of Locomotion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Glutamatergic Synapse Regulation Of Cell Migration Cell-cell Junction Anchoring Junction Cadherin Binding Regulation Of Cellular Component Organization Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Cytoplasm Postsynaptic Density Actin Cytoskeleton Cellular Response To Growth Factor Stimulus ERBB Signaling Pathway Cell Migration Plasma Membrane Intracellular Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Response To Growth Factor Phosphotyrosine Residue Binding Regulation Of Signal Transduction Positive Regulation Of Cell Migration Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Motility Actin Polymerization Or Depolymerization Cell Surface Receptor Signaling Pathway Positive Regulation Of Locomotion Signal Transduction Cell Motility Actin Filament Organization Negative Regulation Of Signal Transduction Regulation Of Actin Filament Organization Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Positive Regulation Of Cellular Component Organization Regulation Of Cell Adhesion Negative Regulation Of Signaling Regulation Of Lymphocyte Migration Developmental Process Negative Regulation Of Cell Communication Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cytoskeleton Organization
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