SORBS2 and PALLD

Number of citations of the paper that reports this interaction (PMID 16125169)
15

Data Source:
BioGRID (two hybrid)

		SORBS2	PALLD
Gene Name		sorbin and SH3 domain containing 2	palladin, cytoskeletal associated protein
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Gene Ontology Annotations	Cellular Component	Nucleus Plasma Membrane Actin Cytoskeleton Z Disc Perinuclear Region Of Cytoplasm	Ruffle Nucleus Cytoplasm Mitochondrion Actin Filament Plasma Membrane Focal Adhesion Actin Cytoskeleton Z Disc Lamellipodium
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Adaptor Activity Structural Constituent Of Muscle Protein Domain Specific Binding Poly(A) RNA Binding Metal Ion Binding	Actin Binding Protein Binding Muscle Alpha-actinin Binding
	Biological Process	Actin Filament Organization Cell Adhesion Biological_process Cell Migration	Cytoskeleton Organization
Pathways
Drugs
Diseases
GWAS		Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Non-alcoholic fatty liver disease histology (AST) ( 20708005) Response to iloperidone treatment (QT prolongation) ( 18521091)
Protein-Protein Interactions		35 interactors: ABL1 ABL2 ACTN1 ADAM15 AKT1 AKT2 ATPAF2 CBL DLGAP1 DLGAP2 DLGAP4 EFS EGFR FLOT1 MDM2 MLLT4 NCK2 NR1H2 PAK1 PAK2 PALLD PKM PTK2B PTPN12 RPL9 SEMA6A SH2D4A SYNJ1 TRAF4 VCL VPS37C WAS WASF1 YWHAE YWHAZ	6 interactors: ACTN1 ACTN2 EZR ITGB5 LIG4 SORBS2
Entrez ID		8470	23022
HPRD ID		12473	09731
Ensembl ID		ENSG00000154556	ENSG00000129116
Uniprot IDs		B7Z3D7 B7Z997 O94875	B2RTX2 Q8WX93
PDB IDs		4IGZ	2DM2 2DM3
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Component Movement Signaling Positive Regulation Of Transport Cell Communication Positive Regulation Of Organelle Organization Programmed Cell Death Regulation Of Cell Motility Cell Death Death Protein Autophosphorylation Regulation Of Cellular Component Organization Cell Activation Regulation Of Locomotion Regulation Of Cellular Ketone Metabolic Process Regulation Of Organelle Organization Positive Regulation Of Intracellular Transport Regulation Of Signaling Axonogenesis Cell Morphogenesis Involved In Differentiation Regulation Of Catalytic Activity Cellular Localization Regulation Of Signal Transduction Apoptotic Process Regulation Of Oxidoreductase Activity Cell Development Axon Development Positive Regulation Of Signal Transduction Fc Receptor Signaling Pathway Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Cellular Localization Regulation Of Intracellular Transport Neuron Projection Development Innate Immune Response Actin Filament Organization Neuron Projection Morphogenesis Neurogenesis Positive Regulation Of Oxidoreductase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Establishment Of Protein Localization Cell Projection Organization Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Cell Adhesion Movement Of Cell Or Subcellular Component Neuron Development Regulation Of Actin Cytoskeleton Organization	Cell Adhesion Actin Filament-based Process Actin Filament Organization Actin Filament Bundle Assembly Actin Cytoskeleton Organization Cell-matrix Adhesion Cell-substrate Adhesion Focal Adhesion Assembly Adherens Junction Assembly Cell-substrate Junction Assembly Cytoskeleton Organization Platelet Degranulation Adherens Junction Organization Single Organismal Cell-cell Adhesion Organelle Organization DNA Ligation Involved In DNA Recombination Cell Activation Cellular Component Assembly Protein Localization To Tight Junction Platelet Activation Cell Junction Assembly Cell-cell Junction Organization Membrane To Membrane Docking Muscle Contraction Lagging Strand Elongation Pro-B Cell Differentiation Microspike Assembly Muscle System Process Establishment Of Integrated Proviral Latency Negative Regulation Of Protein Localization To Cell Surface Protein Localization To Cell Junction Cell Projection Assembly Immunoglobulin V(D)J Recombination Establishment Of Viral Latency T Cell Receptor V(D)J Recombination Negative Regulation Of Potassium Ion Transmembrane Transporter Activity DNA Ligation Involved In DNA Repair Leukocyte Cell-cell Adhesion Cytoskeletal Anchoring At Plasma Membrane Exocytosis Lymphoid Progenitor Cell Differentiation Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Potassium Ion Transmembrane Transport DNA Ligation Stress Fiber Assembly Microvillus Assembly Vesicle-mediated Transport Regulation Of Apoptotic Process
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