SMARCA5 and GSK3A

Number of citations of the paper that reports this interaction (PubMedID 30824926)
69

Data Source:
BioGRID (two hybrid)

		SMARCA5	GSK3A
Description		SNF2 related chromatin remodeling ATPase 5	glycogen synthase kinase 3 alpha
Image
GO Annotations	Cellular Component	Chromatin Condensed Chromosome Fibrillar Center Nucleus Nucleoplasm Chromatin Silencing Complex Chromosome Pericentric Heterochromatin Nucleolus CHRAC NURF Complex ACF Complex ISWI-type Complex RSF Complex Site Of Double-strand Break Nuclear Replication Fork WICH Complex NoRC Complex CERF Complex B-WICH Complex	Nucleus Cytoplasm Mitochondrion Cytosol Axon Beta-catenin Destruction Complex Neuronal Cell Body Apical Dendrite Postsynapse Proximal Dendrite
	Molecular Function	DNA Binding Chromatin Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Nucleosome Binding Histone Binding ATP-dependent Chromatin Remodeler Activity Nucleosome Array Spacer Activity Histone Octamer Slider Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase A Catalytic Subunit Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity
	Biological Process	RDNA Heterochromatin Formation Regulation Of DNA Replication DNA Repair Chromatin Organization Nucleosome Assembly Chromatin Remodeling DNA Methylation-dependent Constitutive Heterochromatin Formation DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA Damage Response Negative Regulation Of Transcription By RNA Polymerase I Heterochromatin Formation Positive Regulation Of DNA Replication Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Antiviral Innate Immune Response Negative Regulation Of Mitotic Chromosome Condensation Cellular Response To Leukemia Inhibitory Factor	Regulation Of Systemic Arterial Blood Pressure Cardiac Left Ventricle Morphogenesis Glycogen Metabolic Process Nervous System Development Insulin Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of UDP-glucose Catabolic Process Regulation Of Neuron Projection Development Wnt Signaling Pathway Cell Migration Viral Protein Processing Cell Differentiation Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of TOR Signaling Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Insulin Stimulus Cellular Response To Interleukin-3 Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Heart Contraction Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of D-glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Excitatory Postsynaptic Potential Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Lithium Ion Cellular Response To Glucocorticoid Stimulus Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Autosome Genomic Imprinting Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitophagy Cellular Response To Oxygen-containing Compound Positive Regulation Of Amyloid-beta Formation Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Establishment Of Protein Localization Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity
Pathways		NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Deposition of new CENPA-containing nucleosomes at the centromere	AKT phosphorylates targets in the cytosol XBP1(S) activates chaperone genes Constitutive Signaling by AKT1 E17K in Cancer Suppression of apoptosis Maturation of nucleoprotein Maturation of nucleoprotein
Drugs		Beta-D-Glucose 4-Deoxy-Alpha-D-Glucose	Fostamatinib
Diseases
GWAS		Appendicular lean mass ( 33097823) Height ( 31562340) Malaria ( 31844061)	Meat-related diet ( 32066663)
Interacting Genes		20 interacting genes: BAZ1A BAZ1B BAZ2A CDT1 CHRAC1 CREB1 CTNNB1 DNMT3B GSK3A H3-3A H3C1 H4C16 HDAC2 MAF POLE3 PTEN RAD21 RSF1 SATB1 USP7	76 interacting genes: AKAP11 AKT1 ALKBH3 AP3D1 AURKAIP1 BCCIP BCL2L1 BCL3 BICD1 C11orf98 CCDC174 CHTOP CNTROB CREB1 CREM DCAF8 DDI1 DEAF1 DNAJB1 DRC1 EBNA1BP2 EIF2B5 FAM193B GLI3 GOLGA6C H2AZ2 HMBS HMGN1 HNRNPM HSF1 HSP90AA1 HSP90AB1 LCOR LDHA LRP6 LRRC37A2 LRSAM1 MAEA MAPT MCL1 MTCH1 MYC MYL12A NBR1 OGT PRKACA PRKCA PRKCB PRKCD PRKCG PRKCH PRKCZ PRKD3 PRKDC PSMD8 PTMA PXN RICTOR RPL15 RPL19 RPL29 RPS15 RPS19 RUNX1 SBNO1 SGK1 SGK3 SMARCA5 SMG7 SPG21 STAT2 SUGP2 TTC16 UBTF VCPIP1 YWHAG
Entrez ID		8467	2931
HPRD ID		04538	06002
Ensembl ID		ENSG00000153147	ENSG00000105723
Uniprot IDs		O60264	P49840
PDB IDs		6NE3 8V4Y 8V6V 8V7L 9E1L 9E1M 9E1N 9E1O 9E1P 9E1Q 9E1R 9E1U 9E1V 9E1W 9E1X	7SXF 7SXG
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Chromatin Organization Protein-DNA Complex Assembly Nucleosome Assembly Nucleosome Organization Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process CHRAC Negative Regulation Of Metabolic Process Epigenetic Regulation Of Gene Expression Regulation Of Metabolic Process Pericentric Heterochromatin DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Chromatin Negative Regulation Of Gene Expression, Epigenetic Macromolecule Metabolic Process Cellular Component Assembly Regulation Of Transcription By RNA Polymerase II Nucleic Acid Metabolic Process Fungiform Papilla Formation Protein-containing Complex Assembly Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Chromosome Organization Negative Regulation Of Chromosome Condensation Regulation Of DNA Replication Negative Regulation Of RNA Metabolic Process Protein-containing Complex Organization Hair Follicle Placode Formation Epsilon DNA Polymerase Complex Regulation Of DNA Metabolic Process Positive Regulation Of Metabolic Process Heterochromatin Formation Negative Regulation Of Gene Expression DNA Replication DNA-templated DNA Replication Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process	Diacylglycerol-dependent Serine/threonine Kinase Activity Response To Peptide Hormone Negative Regulation Of Apoptotic Process Cytosol Negative Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Response To Heat Regulation Of Apoptotic Process Response To Hormone Macromolecule Metabolic Process Nucleoplasm Protein Phosphorylation Protein Serine Kinase Activity Nucleus Cytoplasmic Translation Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Cellular Response To Heat Phosphorylation Protein Serine/threonine Kinase Activity Cellular Response To Stress Protein Kinase C Signaling Response To Temperature Stimulus Positive Regulation Of Immune System Process Cytoplasm Protein Metabolic Process Cellular Response To Peptide Hormone Stimulus Response To Stress Intracellular Signal Transduction Protein Kinase Activity Leukocyte Apoptotic Process Positive Regulation Of Leukocyte Differentiation Translation Macromolecule Biosynthetic Process Positive Regulation Of Protein Localization Positive Regulation Of Metabolic Process Nitric-oxide Synthase Regulator Activity Positive Regulation Of Biosynthetic Process Positive Regulation Of Translation Cellular Response To Oxygen-containing Compound Protein Serine/threonine/tyrosine Kinase Activity CAMP/PKA Signal Transduction DNA Damage Response Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Protein Localization Nucleic Acid Metabolic Process Regulation Of Cellular Component Organization Regulation Of Immune System Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Metabolic Process Kinase Activity
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