SMARCA5 and CHRAC1

Number of citations of the paper that reports this interaction (PubMedID 12434153)
0

Data Source:
HPRD (in vivo)

		SMARCA5	CHRAC1
Description		SNF2 related chromatin remodeling ATPase 5	chromatin accessibility complex subunit 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Condensed Chromosome Fibrillar Center Nucleus Nucleoplasm Chromatin Silencing Complex Chromosome Pericentric Heterochromatin Nucleolus CHRAC NURF Complex ACF Complex ISWI-type Complex RSF Complex Site Of Double-strand Break Nuclear Replication Fork WICH Complex NoRC Complex CERF Complex B-WICH Complex	Nucleus Pericentric Heterochromatin Epsilon DNA Polymerase Complex CHRAC
	Molecular Function	DNA Binding Chromatin Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Nucleosome Binding Histone Binding ATP-dependent Chromatin Remodeler Activity Nucleosome Array Spacer Activity Histone Octamer Slider Activity	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Transferase Activity Nucleotidyltransferase Activity Protein Heterodimerization Activity
	Biological Process	RDNA Heterochromatin Formation Regulation Of DNA Replication DNA Repair Chromatin Organization Nucleosome Assembly Chromatin Remodeling DNA Methylation-dependent Constitutive Heterochromatin Formation DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA Damage Response Negative Regulation Of Transcription By RNA Polymerase I Heterochromatin Formation Positive Regulation Of DNA Replication Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Antiviral Innate Immune Response Negative Regulation Of Mitotic Chromosome Condensation Cellular Response To Leukemia Inhibitory Factor	DNA-templated DNA Replication Regulation Of DNA Replication Nucleosome Assembly Chromatin Remodeling DNA Biosynthetic Process
Pathways		NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Deposition of new CENPA-containing nucleosomes at the centromere
Drugs		Beta-D-Glucose 4-Deoxy-Alpha-D-Glucose
Diseases
GWAS		Appendicular lean mass ( 33097823) Height ( 31562340) Malaria ( 31844061)	Experiencing mood swings ( 29500382)
Interacting Genes		20 interacting genes: BAZ1A BAZ1B BAZ2A CDT1 CHRAC1 CREB1 CTNNB1 DNMT3B GSK3A H3-3A H3C1 H4C16 HDAC2 MAF POLE3 PTEN RAD21 RSF1 SATB1 USP7	5 interacting genes: APP FAM9B POLE3 SMARCA5 UBC
Entrez ID		8467	54108
HPRD ID		04538	06275
Ensembl ID		ENSG00000153147	ENSG00000104472
Uniprot IDs		O60264	Q9NRG0
PDB IDs		6NE3 8V4Y 8V6V 8V7L 9E1L 9E1M 9E1N 9E1O 9E1P 9E1Q 9E1R 9E1U 9E1V 9E1W 9E1X
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Chromatin Organization Protein-DNA Complex Assembly Nucleosome Assembly Nucleosome Organization Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process CHRAC Negative Regulation Of Metabolic Process Epigenetic Regulation Of Gene Expression Regulation Of Metabolic Process Pericentric Heterochromatin DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Chromatin Negative Regulation Of Gene Expression, Epigenetic Macromolecule Metabolic Process Cellular Component Assembly Regulation Of Transcription By RNA Polymerase II Nucleic Acid Metabolic Process Fungiform Papilla Formation Protein-containing Complex Assembly Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Chromosome Organization Negative Regulation Of Chromosome Condensation Regulation Of DNA Replication Negative Regulation Of RNA Metabolic Process Protein-containing Complex Organization Hair Follicle Placode Formation Epsilon DNA Polymerase Complex Regulation Of DNA Metabolic Process Positive Regulation Of Metabolic Process Heterochromatin Formation Negative Regulation Of Gene Expression DNA Replication DNA-templated DNA Replication Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process	CHRAC Epigenetic Regulation Of Gene Expression Pericentric Heterochromatin Acetylcholine Receptor Activator Activity Amyloid-beta Complex Growth Cone Lamellipodium Chromatin Remodeling Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Lipoprotein Particle Positive Regulation Of Protein Import WICH Complex Negative Regulation Of Mitotic Chromosome Condensation Nucleosome Assembly ISWI-type Complex Regulation Of DNA Replication NoRC Complex Histone Octamer Slider Activity RSF Complex ACF Complex Nucleosome Organization PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Heterochromatin Formation Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Chromatin Organization Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling CERF Complex Negative Regulation Of Chromosome Condensation Negative Regulation Of Gene Expression, Epigenetic Leading Strand Elongation Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Nucleosome Array Spacer Activity Protein-DNA Complex Assembly Epsilon DNA Polymerase Complex
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