CEP76 and WDFY3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		CEP76	WDFY3
Description		centrosomal protein 76	WD repeat and FYVE domain containing 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Protein-containing Complex	Autophagosome Membrane Nucleus Nuclear Envelope Nucleoplasm Nucleolus Cytoplasm Autophagosome Cytosol Plasma Membrane Membrane Inclusion Body PML Body Axon Nuclear Membrane Atg12-Atg5-Atg16 Complex Cell Projection Perikaryon
	Molecular Function	Protein Binding	Protein Binding 1-phosphatidylinositol Binding Zinc Ion Binding Lipid Binding Metal Ion Binding
	Biological Process	Regulation Of Centriole Replication	Autophagy Macroautophagy Aggrephagy
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS			Cerebral amyloid deposition (PET imaging) ( 26252872) Monocyte percentage of white cells ( 32888494) Oropharynx cancer ( 27749845)
Interacting Genes		105 interacting genes: AKAP7 AKT1 ANKRD36 ASH2L BANP C22orf39 CABP5 CACNB3 CAPN3 CAVIN3 CCDC92 CCNK CDK18 CENPI CIRSR COIL CRYBA4 CSNK1G1 CUTC CWF19L2 DCTD DDX6 DEAF1 DMTN DVL3 DZIP1L EAF1 EIF1AD EP400P1 ERCC3 FAM90A1 GDAP2 GFAP GORASP2 HACL2 HSF2 HSPB7 IQUB KDM1A KDM4D KIAA1143 KIFBP KLHDC4 L3MBTL2 LATS1 LNX1 MAGEA11 MBD3 MFAP1 MISP MLH1 MYOZ1 NEK6 NFYC NHLRC2 NME5 PAICS PARD6B PATZ1 PDGFRB PDRG1 PDZD4 PDZD7 PIN1 PKP1 PLA2G6 PLCB1 POM121 RADIL RALGPS1 RBM41 RIPPLY3 RNF128 RPL9 SALL2 SCNM1 SH2D4A SINHCAF SMG9 SPG21 STK26 SUOX TBC1D27P TCEA2 TCEANC TCF19 TFAP2D THRA TOB2 TSPOAP1 TSSC4 TTC21A TTLL10 TUFT1 TXNDC9 VEZF1 WDFY3 YY1 ZBTB24 ZBTB4 ZMAT2 ZNF185 ZNF653 ZNF76 ZNF85	16 interacting genes: ATG5 BTG3 CEP76 GABARAPL1 GABARAPL2 GRB2 MAP1LC3C MDFI PRMT1 PRMT6 RABGAP1L STAT3 SUV39H1 TNS2 TRIM39 ZBTB44
Entrez ID		79959	23001
HPRD ID		12694	10304
Ensembl ID		ENSG00000101624	ENSG00000163625
Uniprot IDs		B4DP81 Q8TAP6	Q8IZQ1
PDB IDs			3WIM 6W9N
Enriched GO Terms of Interacting Partners?		Protein Binding Nucleus	Cellular Response To Nitrogen Starvation Cellular Response To Starvation Response To Starvation Cellular Response To Nutrient Levels Mitophagy Phosphatidylethanolamine Binding Autophagy Of Mitochondrion Autophagosome Autophagosome Assembly Autophagosome Organization Cellular Response To Stress Response To Nutrient Levels Histone Methyltransferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Histone H4R3 Methyltransferase Activity Macroautophagy Autophagosome Maturation Protein-arginine Omega-N Asymmetric Methyltransferase Activity Vacuole Organization Autophagosome Membrane Protein-arginine N-methyltransferase Activity Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Aggrephagy Response To Stress GABA Receptor Binding Autophagy Negative Regulation Of Protein Metabolic Process Phospholipid Binding Histone H3 Methyltransferase Activity Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Proteolysis Protein-containing Complex Disassembly Negative Regulation Of Catabolic Process Organelle Assembly Methyltransferase Activity Positive Regulation Of Erythrocyte Differentiation Regulation Of Megakaryocyte Differentiation DNA Damage Response Beta-tubulin Binding Protein Sequestering Activity Methylation Cytoplasmic Vesicle Guanyl-nucleotide Exchange Factor Adaptor Activity GATOR1 Complex Binding Histone H2AR3 Methyltransferase Activity Regulation Of Erythrocyte Differentiation Negative Regulation Of Macromolecule Metabolic Process Regulation Of Myeloid Cell Differentiation Cytoplasm Negative Regulation Of Proteasomal Protein Catabolic Process
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