CEP76 and STK26

Number of citations of the paper that reports this interaction (PubMedID 21516116)
20

Data Source:
BioGRID (two hybrid)

		CEP76	STK26
Description		centrosomal protein 76	serine/threonine kinase 26
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Protein-containing Complex	Cytoplasm Golgi Apparatus Golgi-associated Vesicle Cytosol Vesicle Membrane Membrane Apical Plasma Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery FAR/SIN/STRIPAK Complex
	Molecular Function	Protein Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Regulation Of Centriole Replication	Protein Phosphorylation Apoptotic Process Cellular Response To Starvation Negative Regulation Of Cell Migration Cellular Response To Oxidative Stress Intracellular Signal Transduction Regulation Of Apoptotic Process Protein Autophosphorylation Positive Regulation Of Microvillus Assembly
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	Apoptotic cleavage of cellular proteins
Drugs			2-[4-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl]iminocyclohexa-2,5-dien-1-yl]acetonitrile Fostamatinib
Diseases
GWAS			Gestational age at birth (maternal effect) ( 28877031)
Interacting Genes		105 interacting genes: AKAP7 AKT1 ANKRD36 ASH2L BANP C22orf39 CABP5 CACNB3 CAPN3 CAVIN3 CCDC92 CCNK CDK18 CENPI CIRSR COIL CRYBA4 CSNK1G1 CUTC CWF19L2 DCTD DDX6 DEAF1 DMTN DVL3 DZIP1L EAF1 EIF1AD EP400P1 ERCC3 FAM90A1 GDAP2 GFAP GORASP2 HACL2 HSF2 HSPB7 IQUB KDM1A KDM4D KIAA1143 KIFBP KLHDC4 L3MBTL2 LATS1 LNX1 MAGEA11 MBD3 MFAP1 MISP MLH1 MYOZ1 NEK6 NFYC NHLRC2 NME5 PAICS PARD6B PATZ1 PDGFRB PDRG1 PDZD4 PDZD7 PIN1 PKP1 PLA2G6 PLCB1 POM121 RADIL RALGPS1 RBM41 RIPPLY3 RNF128 RPL9 SALL2 SCNM1 SH2D4A SINHCAF SMG9 SPG21 STK26 SUOX TBC1D27P TCEA2 TCEANC TCF19 TFAP2D THRA TOB2 TSPOAP1 TSSC4 TTC21A TTLL10 TUFT1 TXNDC9 VEZF1 WDFY3 YY1 ZBTB24 ZBTB4 ZMAT2 ZNF185 ZNF653 ZNF76 ZNF85	13 interacting genes: APP CEP76 CFTR GOLGA2 GRB14 IKZF3 MBP NEDD4 OGT RAF1 SRPK1 TRAF6 TRIM27
Entrez ID		79959	51765
HPRD ID		12694	06663
Ensembl ID		ENSG00000101624	ENSG00000134602
Uniprot IDs		B4DP81 Q8TAP6	Q9P289
PDB IDs			3GGF 3W8I 4FZA 4FZD 4FZF 4GEH 5XY9 5YF4 7B36
Enriched GO Terms of Interacting Partners?		Protein Binding Nucleus	Positive Regulation Of Protein Metabolic Process Protein-containing Complex Enzyme Binding Cytosol Protein K63-linked Ubiquitination Positive Regulation Of Macromolecule Metabolic Process Innate Immune Response Positive Regulation Of Interleukin-6 Production Regulation Of Protein Metabolic Process Response To Other Organism Protein Modification Process Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Immune Response Positive Regulation Of Metabolic Process Intracellular Signal Transduction Homeostatic Process Defense Response To Symbiont Defense Response To Other Organism Regulation Of Interleukin-6 Production Positive Regulation Of Biosynthetic Process Response To External Biotic Stimulus Cytoplasm Immune System Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Receptor Localization To Synapse Regulation Of Protein Localization To Synapse Defense Response Negative Regulation Of Signal Transduction Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Proteolysis Amyloid-beta Complex Regulation Of Phosphorus Metabolic Process Growth Cone Lamellipodium Regulation Of Primary Metabolic Process Protein Metabolic Process Positive Regulation Of Cytokine Production Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Negative Regulation Of Transcription By RNA Polymerase II Response To Stress Amylin Binding Negative Regulation Of Signaling Positive Regulation Of Toll Signaling Pathway Developmental Process Intracellular Chemical Homeostasis Leukocyte Activation Negative Regulation Of Cell Communication Establishment Of Localization In Cell Regulation Of Cellular Localization Intracellularly ATP-gated Chloride Channel Activity
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