CEP76 and TOB2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		CEP76	TOB2
Description		centrosomal protein 76	transducer of ERBB2, 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Protein-containing Complex	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding	Transcription Corepressor Activity Protein Binding Nuclear Vitamin D Receptor Binding
	Biological Process	Regulation Of Centriole Replication	Female Gamete Generation Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Osteoclast Differentiation Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Ossification Negative Regulation Of DNA-templated Transcription
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 31361310) Autism spectrum disorder or schizophrenia ( 28540026) Meat-related diet ( 32066663) Neuroticism ( 29255261) Refractive error ( 32231278) Vitiligo ( 22561518)
Interacting Genes		105 interacting genes: AKAP7 AKT1 ANKRD36 ASH2L BANP C22orf39 CABP5 CACNB3 CAPN3 CAVIN3 CCDC92 CCNK CDK18 CENPI CIRSR COIL CRYBA4 CSNK1G1 CUTC CWF19L2 DCTD DDX6 DEAF1 DMTN DVL3 DZIP1L EAF1 EIF1AD EP400P1 ERCC3 FAM90A1 GDAP2 GFAP GORASP2 HACL2 HSF2 HSPB7 IQUB KDM1A KDM4D KIAA1143 KIFBP KLHDC4 L3MBTL2 LATS1 LNX1 MAGEA11 MBD3 MFAP1 MISP MLH1 MYOZ1 NEK6 NFYC NHLRC2 NME5 PAICS PARD6B PATZ1 PDGFRB PDRG1 PDZD4 PDZD7 PIN1 PKP1 PLA2G6 PLCB1 POM121 RADIL RALGPS1 RBM41 RIPPLY3 RNF128 RPL9 SALL2 SCNM1 SH2D4A SINHCAF SMG9 SPG21 STK26 SUOX TBC1D27P TCEA2 TCEANC TCF19 TFAP2D THRA TOB2 TSPOAP1 TSSC4 TTC21A TTLL10 TUFT1 TXNDC9 VEZF1 WDFY3 YY1 ZBTB24 ZBTB4 ZMAT2 ZNF185 ZNF653 ZNF76 ZNF85	7 interacting genes: BHLHE40 CEP76 CNOT7 CNOT8 PABPC1 RPS6KA1 TMEM132D
Entrez ID		79959	10766
HPRD ID		12694	09583
Ensembl ID		ENSG00000101624	ENSG00000183864
Uniprot IDs		B4DP81 Q8TAP6	Q14106
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding Nucleus	Regulation Of Translation Positive Regulation Of MRNA Catabolic Process CCR4-NOT Complex CCR4-NOT Core Complex Poly(A)-specific Ribonuclease Activity Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of MRNA Metabolic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulatory NcRNA-mediated Gene Silencing Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Post-transcriptional Regulation Of Gene Expression RNA Catabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability 3'-5'-RNA Exonuclease Activity Positive Regulation Of Viral Genome Replication MiRNA-mediated Gene Silencing By MRNA Destabilization Exonuclease Activity Regulation Of MRNA Metabolic Process Nucleobase-containing Compound Catabolic Process Positive Regulation Of Viral Process Regulation Of Viral Genome Replication Cytoplasmic Ribonucleoprotein Granule MRNA Destabilization P-body RNA Destabilization MiRNA-mediated Post-transcriptional Gene Silencing Regulation Of Viral Life Cycle Nuclease Activity Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Positive Regulation Of Catabolic Process Nucleic Acid Binding Post-transcriptional Gene Silencing Regulation Of Viral Process MRNA Metabolic Process PiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Protein Metabolic Process Positive Regulation Of Hepatic Stellate Cell Activation MRF Binding MCRD-mediated MRNA Stability Complex Ribosomal Protein S6 Kinase Activity Hepatocyte Proliferation PiRNA Binding Positive Regulation Of RNA Metabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay CRD-mediated MRNA Stabilization
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