CEP76 and KLHDC4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		CEP76	KLHDC4
Description		centrosomal protein 76	kelch domain containing 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Protein-containing Complex
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Regulation Of Centriole Replication
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS			Hippocampal volume in mild cognitive impairment ( 29274321)
Interacting Genes		105 interacting genes: AKAP7 AKT1 ANKRD36 ASH2L BANP C22orf39 CABP5 CACNB3 CAPN3 CAVIN3 CCDC92 CCNK CDK18 CENPI CIRSR COIL CRYBA4 CSNK1G1 CUTC CWF19L2 DCTD DDX6 DEAF1 DMTN DVL3 DZIP1L EAF1 EIF1AD EP400P1 ERCC3 FAM90A1 GDAP2 GFAP GORASP2 HACL2 HSF2 HSPB7 IQUB KDM1A KDM4D KIAA1143 KIFBP KLHDC4 L3MBTL2 LATS1 LNX1 MAGEA11 MBD3 MFAP1 MISP MLH1 MYOZ1 NEK6 NFYC NHLRC2 NME5 PAICS PARD6B PATZ1 PDGFRB PDRG1 PDZD4 PDZD7 PIN1 PKP1 PLA2G6 PLCB1 POM121 RADIL RALGPS1 RBM41 RIPPLY3 RNF128 RPL9 SALL2 SCNM1 SH2D4A SINHCAF SMG9 SPG21 STK26 SUOX TBC1D27P TCEA2 TCEANC TCF19 TFAP2D THRA TOB2 TSPOAP1 TSSC4 TTC21A TTLL10 TUFT1 TXNDC9 VEZF1 WDFY3 YY1 ZBTB24 ZBTB4 ZMAT2 ZNF185 ZNF653 ZNF76 ZNF85	8 interacting genes: CEP76 KDM1A MFHAS1 SUV39H1 SUV39H2 TERF1 TRIM55 TRIM63
Entrez ID		79959	54758
HPRD ID		12694	11180
Ensembl ID		ENSG00000101624	ENSG00000104731
Uniprot IDs		B4DP81 Q8TAP6	Q8TBB5
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding Nucleus	Histone H3K9 Trimethyltransferase Activity Histone H3K9 Methyltransferase Activity Epigenetic Programming In The Zygotic Pronuclei Histone H3 Methyltransferase Activity Telomeric DNA Binding Epigenetic Programming Of Gene Expression Histone Methyltransferase Activity Chromosome Epigenetic Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Regulation Of DNA Metabolic Process ENoSc Complex Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Cellular Response To Hypoxia Circadian Rhythm Cellular Response To Decreased Oxygen Levels Protein Demethylase Activity Chromosome, Centromeric Region Cellular Response To Oxygen Levels Negative Regulation Of Gene Expression, Epigenetic Chromatin Remodeling Methyltransferase Activity RDNA Heterochromatin Formation RDNA Heterochromatin Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Establishment Of Protein Localization To Telomere Telomerase Activity Shelterin Complex Ankyrin Repeat Binding Chromosome, Telomeric Region Innate Immune Response Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Response To Fungicide MRF Binding Guanine Metabolic Process Diapedesis Skeletal Muscle Atrophy Skeletal Muscle Adaptation Striated Muscle Atrophy Histone H3K9me2 Methyltransferase Activity
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