CEP76 and PLCB1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		CEP76	PLCB1
Description		centrosomal protein 76	phospholipase C beta 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Protein-containing Complex	Chromatin Nucleus Cytoplasm Cytosol Membrane Nuclear Speck Nuclear Membrane Protein-containing Complex Extracellular Exosome Glutamatergic Synapse GABA-ergic Synapse Postsynaptic Cytosol
	Molecular Function	Protein Binding	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Phospholipase C Activity GTPase Activator Activity Calcium Ion Binding Protein Binding Calmodulin Binding Lamin Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Enzyme Binding Identical Protein Binding Phosphatidylinositol Phospholipase C Activity
	Biological Process	Regulation Of Centriole Replication	G2/M Transition Of Mitotic Cell Cycle Lipid Metabolic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Learning Memory Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Glycoprotein Biosynthetic Process Lipid Catabolic Process Cerebral Cortex Development Phosphatidylinositol Catabolic Process Positive Regulation Of Insulin Secretion Positive Regulation Of Interleukin-12 Production Inositol Trisphosphate Metabolic Process Response To Monosaccharide Intracellular Signal Transduction Interleukin-12-mediated Signaling Pathway Interleukin-15-mediated Signaling Pathway Positive Regulation Of Embryonic Development Response To Peptide Hormone Fat Cell Differentiation Positive Regulation Of Myoblast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of JNK Cascade Phosphatidylinositol Metabolic Process Insulin-like Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Developmental Growth Release Of Sequestered Calcium Ion Into Cytosol Activation Of Meiosis Involved In Egg Activation Interleukin-1-mediated Signaling Pathway Regulation Of Fertilization Postsynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Retrograde Trans-synaptic Signaling By Endocanabinoid Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Fluoride Regulation Of Establishment Of Endothelial Barrier Cellular Response To Vasopressin Cellular Response To Ionomycin Cellular Response To Glyceraldehyde Ligand-gated Ion Channel Signaling Pathway Positive Regulation Of Acrosome Reaction Negative Regulation Of Monocyte Extravasation
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	PLC beta mediated events PLC beta mediated events Synthesis of IP3 and IP4 in the cytosol Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion Ca2+ pathway G alpha (q) signalling events G alpha (q) signalling events G beta:gamma signalling through PLC beta Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Presynaptic function of Kainate receptors
Drugs
Diseases			Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS			Adverse response to drug ( 30420678) Chronic kidney disease ( 26420894) Cognitive performance ( 20125193 19734545) Colorectal cancer ( 23263487) Daytime sleep phenotypes ( 27126917) Diastolic blood pressure ( 28135244) Estimated glomerular filtration rate ( 31451708 31152163) Fasting glucose ( 34074324) Femur bone mineral density x serum urate levels interaction ( 34046847) Hematocrit ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lateral ventricle temporal horn volume ( 31530798) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Metabolite levels ( 23823483) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494) Neuritic plaque ( 31497858) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Obstructive sleep apnea trait (average respiratory event duration) ( 26977737) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Response to irinotecan in non-small-cell lung cancer ( 22664479) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Social communication problems ( 24564958) Suicide ideation score in major depressive disorder ( 26079190) White blood cell count ( 32888494 27863252)
Interacting Genes		105 interacting genes: AKAP7 AKT1 ANKRD36 ASH2L BANP C22orf39 CABP5 CACNB3 CAPN3 CAVIN3 CCDC92 CCNK CDK18 CENPI CIRSR COIL CRYBA4 CSNK1G1 CUTC CWF19L2 DCTD DDX6 DEAF1 DMTN DVL3 DZIP1L EAF1 EIF1AD EP400P1 ERCC3 FAM90A1 GDAP2 GFAP GORASP2 HACL2 HSF2 HSPB7 IQUB KDM1A KDM4D KIAA1143 KIFBP KLHDC4 L3MBTL2 LATS1 LNX1 MAGEA11 MBD3 MFAP1 MISP MLH1 MYOZ1 NEK6 NFYC NHLRC2 NME5 PAICS PARD6B PATZ1 PDGFRB PDRG1 PDZD4 PDZD7 PIN1 PKP1 PLA2G6 PLCB1 POM121 RADIL RALGPS1 RBM41 RIPPLY3 RNF128 RPL9 SALL2 SCNM1 SH2D4A SINHCAF SMG9 SPG21 STK26 SUOX TBC1D27P TCEA2 TCEANC TCF19 TFAP2D THRA TOB2 TSPOAP1 TSSC4 TTC21A TTLL10 TUFT1 TXNDC9 VEZF1 WDFY3 YY1 ZBTB24 ZBTB4 ZMAT2 ZNF185 ZNF653 ZNF76 ZNF85	18 interacting genes: CEP76 CTBP1 CTBP2 GNAQ GRK2 MAPK1 MAPK3 NHERF1 PARD3 PARD6A PRKCA PRKCD RGS12 RGS4 SPTBN1 TFCP2 TRPC3 TRPM7
Entrez ID		79959	23236
HPRD ID		12694	06177
Ensembl ID		ENSG00000101624	ENSG00000182621
Uniprot IDs		B4DP81 Q8TAP6	Q9NQ66
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding Nucleus	Viral Genome Replication Protein Phosphorylation Protein Serine/threonine Kinase Activity Phosphorylation Interleukin-34-mediated Signaling Pathway G Protein-coupled Receptor Signaling Pathway Regulation Of Transport Protein Kinase Activity Plasma Membrane Protein Kinase C Signaling Regulation Of Cellular Localization Caveolin-mediated Endocytosis Regulation Of Golgi Inheritance Positive Regulation Of Macrophage Proliferation Regulation Of System Process Viral Process PAR Polarity Complex Regulation Of G Protein-coupled Receptor Signaling Pathway Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cardiac Neural Crest Cell Development Involved In Heart Development Phosphatase Binding Trachea Formation Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Platelet Activation Protein Serine Kinase Activity Kinase Activity Regulation Of Multicellular Organismal Process Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Bergmann Glial Cell Differentiation Regulation Of Signal Transduction Regulation Of Cardiac Muscle Hypertrophy Regulation Of Biological Quality Regulation Of Muscle System Process White Fat Cell Differentiation Diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Golgi Organization MAP Kinase Activity Myelination Axon Ensheathment Pseudopodium Regulation Of Early Endosome To Late Endosome Transport Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cytoskeleton Organization Schwann Cell Development Intracellular Chemical Homeostasis Ruffle
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