CEP76 and RALGPS1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CEP76	RALGPS1
Description		centrosomal protein 76	Ral GEF with PH domain and SH3 binding motif 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Protein-containing Complex	Cytoplasm Plasma Membrane Membrane
	Molecular Function	Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Regulation Of Centriole Replication	Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Regulation Of Ral Protein Signal Transduction Intracellular Signal Transduction
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS			Appendicular lean mass ( 33097823) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Early-onset schizophrenia ( 33907183) Intraocular pressure ( 29617998 29785010 31959993) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Post bronchodilator FEV1/FVC ratio ( 26634245) Schizophrenia ( 30285260)
Interacting Genes		105 interacting genes: AKAP7 AKT1 ANKRD36 ASH2L BANP C22orf39 CABP5 CACNB3 CAPN3 CAVIN3 CCDC92 CCNK CDK18 CENPI CIRSR COIL CRYBA4 CSNK1G1 CUTC CWF19L2 DCTD DDX6 DEAF1 DMTN DVL3 DZIP1L EAF1 EIF1AD EP400P1 ERCC3 FAM90A1 GDAP2 GFAP GORASP2 HACL2 HSF2 HSPB7 IQUB KDM1A KDM4D KIAA1143 KIFBP KLHDC4 L3MBTL2 LATS1 LNX1 MAGEA11 MBD3 MFAP1 MISP MLH1 MYOZ1 NEK6 NFYC NHLRC2 NME5 PAICS PARD6B PATZ1 PDGFRB PDRG1 PDZD4 PDZD7 PIN1 PKP1 PLA2G6 PLCB1 POM121 RADIL RALGPS1 RBM41 RIPPLY3 RNF128 RPL9 SALL2 SCNM1 SH2D4A SINHCAF SMG9 SPG21 STK26 SUOX TBC1D27P TCEA2 TCEANC TCF19 TFAP2D THRA TOB2 TSPOAP1 TSSC4 TTC21A TTLL10 TUFT1 TXNDC9 VEZF1 WDFY3 YY1 ZBTB24 ZBTB4 ZMAT2 ZNF185 ZNF653 ZNF76 ZNF85	5 interacting genes: AKAP19 APP CEP76 GRB2 RALA
Entrez ID		79959	9649
HPRD ID		12694	11479
Ensembl ID		ENSG00000101624	ENSG00000136828
Uniprot IDs		B4DP81 Q8TAP6	Q5JS13
PDB IDs			3QXL
Enriched GO Terms of Interacting Partners?		Protein Binding Nucleus	Amyloid-beta Complex Growth Cone Lamellipodium Synaptic Membrane Regulation Of Response To Calcium Ion Amylin Binding Ephrin Receptor Binding Positive Regulation Of Toll Signaling Pathway Endocytosis Regulation Of Receptor Internalization Positive Regulation Of Reactive Oxygen Species Metabolic Process Glial Cell Development Receptor Internalization Guanyl-nucleotide Exchange Factor Adaptor Activity Ras Protein Signal Transduction Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Regulation Of Reactive Oxygen Species Metabolic Process Growth Cone Filopodium Regulation Of Receptor-mediated Endocytosis Lipoprotein Particle Import Into Cell Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Grb2-EGFR Complex Edg-2 Lysophosphatidic Acid Receptor Binding Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intracellular Signaling Cassette Positive Regulation Of Supramolecular Fiber Organization Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Receptor-mediated Endocytosis Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Neurotrophin TRKA Receptor Binding Regulation Of Cellular Component Organization
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