SYVN1 and ATL1

Number of citations of the paper that reports this interaction (PubMedID 32916628)
43

Data Source:
BioGRID (enzymatic study)

		SYVN1	ATL1
Description		synoviolin 1	atlastin GTPase 1
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GO Annotations	Cellular Component	Hrd1p Ubiquitin Ligase Complex Hrd1p Ubiquitin Ligase ERAD-L Complex Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Endomembrane System Membrane Derlin-1 Retrotranslocation Complex Endoplasmic Reticulum Quality Control Compartment	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Axon Cell Projection Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Membrane Endoplasmic Reticulum Subcompartment Golgi Cis Cisterna Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Unfolded Protein Binding Protein-folding Chaperone Binding ATPase Binding Ubiquitin Protein Ligase Activity DNA-binding Transcription Factor Binding Ubiquitin-specific Protease Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Identical Protein Binding GTPase-dependent Fusogenic Activity
	Biological Process	Immature B Cell Differentiation Negative Regulation Of T-helper 1 Type Immune Response Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Retrograde Protein Transport, ER To Cytosol ERAD Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Stabilization Protein K48-linked Ubiquitination Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Endoplasmic Reticulum Mannose Trimming	Endoplasmic Reticulum Organization Axonogenesis Endoplasmic Reticulum Membrane Fusion Protein Homooligomerization Endoplasmic Reticulum Tubular Network Membrane Organization
Pathways		XBP1(S) activates chaperone genes Hedgehog ligand biogenesis Hh mutants are degraded by ERAD ER Quality Control Compartment (ERQC)
Drugs
Diseases			Hereditary spastic paraplegia (SPG)
GWAS		Crohn's disease ( 32581322)	Cognitive performance ( 20125193) Dupuytren's disease ( 28886342) Femur bone mineral density x serum urate levels interaction ( 34046847) Periodontal disease-related phenotype (Socransky) ( 24347629)
Interacting Genes		17 interacting genes: APP ATL1 ATN1 CLU ERN1 GPR37 SLC35F2 TP53 TRIM59 UBE2D2 UBE2D3 UBE2G1 UBE2J1 UBE2U UBE2Z USP15 USP7	1 interacting genes: SYVN1
Entrez ID		84447	51062
HPRD ID		07618	05918
Ensembl ID		ENSG00000162298	ENSG00000198513
Uniprot IDs		Q86TM6	A0A0S2Z5A2 A0A0S2Z5B0 Q53F53 Q8WXF7
PDB IDs		6A3Z 8KES 8KET 8KEV	3Q5D 3Q5E 3QNU 3QOF 4IDN 4IDO 4IDP 4IDQ 6B9D 6B9E 6B9F 6B9G 6XJN 7OL3
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Post-translational Protein Modification Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Modification Process Protein Polyubiquitination Proteolysis Positive Regulation Of Amyloid Fibril Formation Ubiquitin Protein Ligase Binding Apoptotic Process Protein Metabolic Process Programmed Cell Death Cell Death Regulation Of Intrinsic Apoptotic Signaling Pathway Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process Monoubiquitinated Protein Deubiquitination Endoplasmic Reticulum Protein-containing Complex Regulation Of Response To Endoplasmic Reticulum Stress Nucleotide Binding Transferase Activity Protein-folding Chaperone Binding Regulation Of Amyloid Fibril Formation Regulation Of Cellular Response To Stress K48-linked Deubiquitinase Activity Protein K48-linked Ubiquitination Ubiquitin-like Protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Regulation Of Amyloid-beta Clearance Modification-dependent Protein Catabolic Process Response To Stress Negative Regulation Of Signal Transduction Release Of Cytochrome C From Mitochondria ATP Binding Catabolic Process Regulation Of Signal Transduction By P53 Class Mediator Molecular Function Activator Activity Deubiquitinase Activity Low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Signaling Macromolecule Metabolic Process Negative Regulation Of Cell Communication Glial Cell Proliferation Central Nervous System Development Positive Regulation Of Apoptotic Signaling Pathway Microglial Cell Activation Regulation Of Proteolysis	Nucleoplasm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cullin-RING Ubiquitin Ligase Complex Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Cul2-RING Ubiquitin Ligase Complex Microtubule Anchoring At Centrosome Collateral Sprouting Corticospinal Tract Morphogenesis Ciliary Basal Body Centriolar Subdistal Appendage Ciliary Transition Fiber Centriole-centriole Cohesion Microtubule Nucleation By Microtubule Organizing Center Microtubule Minus-end Binding Corpus Callosum Morphogenesis Centrosome-templated Microtubule Nucleation Microtubule Anchoring At Microtubule Organizing Center Dynein Axonemal Particle Regulation Of Protein Stability Outer Dynein Arm Assembly Establishment Of Left/right Asymmetry Protein Stabilization Inner Dynein Arm Assembly Hrd1p Ubiquitin Ligase ERAD-L Complex Retrograde Protein Transport, ER To Cytosol Protein Alpha-1,2-demannosylation Negative Regulation Of T-helper 1 Type Immune Response Endoplasmic Reticulum Mannose Trimming Smooth Endoplasmic Reticulum Immature B Cell Differentiation Ubiquitin-specific Protease Binding Hrd1p Ubiquitin Ligase Complex Derlin-1 Retrotranslocation Complex Protein Deglycosylation Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Axonal Growth Cone Pericentriolar Material Central Nervous System Projection Neuron Axonogenesis Microtubule Anchoring Endoplasmic Reticulum Quality Control Compartment Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Catabolic Process Protein Ubiquitination Microtubule Nucleation Central Nervous System Neuron Axonogenesis Centrosome Localization Protein Folding Chaperone Complex Protein Exit From Endoplasmic Reticulum
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