SYVN1 and SLC35F2

Number of citations of the paper that reports this interaction (PubMedID 37740007)
0

Data Source:
BioGRID (pull down)

		SYVN1	SLC35F2
Description		synoviolin 1	solute carrier family 35 member F2
Image			No pdb structure
GO Annotations	Cellular Component	Hrd1p Ubiquitin Ligase Complex Hrd1p Ubiquitin Ligase ERAD-L Complex Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Endomembrane System Membrane Derlin-1 Retrotranslocation Complex Endoplasmic Reticulum Quality Control Compartment	Cellular_component Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Unfolded Protein Binding Protein-folding Chaperone Binding ATPase Binding Ubiquitin Protein Ligase Activity DNA-binding Transcription Factor Binding Ubiquitin-specific Protease Binding	Molecular_function Transmembrane Transporter Activity
	Biological Process	Immature B Cell Differentiation Negative Regulation Of T-helper 1 Type Immune Response Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Retrograde Protein Transport, ER To Cytosol ERAD Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Stabilization Protein K48-linked Ubiquitination Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Endoplasmic Reticulum Mannose Trimming	Biological_process Transmembrane Transport
Pathways		XBP1(S) activates chaperone genes Hedgehog ligand biogenesis Hh mutants are degraded by ERAD ER Quality Control Compartment (ERQC)
Drugs
Diseases
GWAS		Crohn's disease ( 32581322)	Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885)
Interacting Genes		17 interacting genes: APP ATL1 ATN1 CLU ERN1 GPR37 SLC35F2 TP53 TRIM59 UBE2D2 UBE2D3 UBE2G1 UBE2J1 UBE2U UBE2Z USP15 USP7	1 interacting genes: SYVN1
Entrez ID		84447	54733
HPRD ID		07618	15377
Ensembl ID		ENSG00000162298	ENSG00000110660
Uniprot IDs		Q86TM6	Q8IXU6
PDB IDs		6A3Z 8KES 8KET 8KEV
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Post-translational Protein Modification Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Modification Process Protein Polyubiquitination Proteolysis Positive Regulation Of Amyloid Fibril Formation Ubiquitin Protein Ligase Binding Apoptotic Process Protein Metabolic Process Programmed Cell Death Cell Death Regulation Of Intrinsic Apoptotic Signaling Pathway Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process Monoubiquitinated Protein Deubiquitination Endoplasmic Reticulum Protein-containing Complex Regulation Of Response To Endoplasmic Reticulum Stress Nucleotide Binding Transferase Activity Protein-folding Chaperone Binding Regulation Of Amyloid Fibril Formation Regulation Of Cellular Response To Stress K48-linked Deubiquitinase Activity Protein K48-linked Ubiquitination Ubiquitin-like Protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Regulation Of Amyloid-beta Clearance Modification-dependent Protein Catabolic Process Response To Stress Negative Regulation Of Signal Transduction Release Of Cytochrome C From Mitochondria ATP Binding Catabolic Process Regulation Of Signal Transduction By P53 Class Mediator Molecular Function Activator Activity Deubiquitinase Activity Low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Signaling Macromolecule Metabolic Process Negative Regulation Of Cell Communication Glial Cell Proliferation Central Nervous System Development Positive Regulation Of Apoptotic Signaling Pathway Microglial Cell Activation Regulation Of Proteolysis	Hrd1p Ubiquitin Ligase ERAD-L Complex Retrograde Protein Transport, ER To Cytosol Protein Alpha-1,2-demannosylation Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of T-helper 1 Type Immune Response Endoplasmic Reticulum Mannose Trimming Smooth Endoplasmic Reticulum Immature B Cell Differentiation Ubiquitin-specific Protease Binding Hrd1p Ubiquitin Ligase Complex Derlin-1 Retrotranslocation Complex Protein Deglycosylation Endoplasmic Reticulum Quality Control Compartment Protein Exit From Endoplasmic Reticulum Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Adaptive Immune Response ATPase Binding Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway B Cell Differentiation Protein-folding Chaperone Binding Unfolded Protein Binding Protein K48-linked Ubiquitination Negative Regulation Of Intrinsic Apoptotic Signaling Pathway B Cell Activation DNA-binding Transcription Factor Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Negative Regulation Of Immune Response Regulation Of Adaptive Immune Response Response To Endoplasmic Reticulum Stress Negative Regulation Of Apoptotic Signaling Pathway Protein Stabilization Lymphocyte Differentiation Glycoprotein Metabolic Process Endomembrane System
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