MAML2 and DIABLO

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		MAML2	DIABLO
Gene Name		mastermind-like 2 (Drosophila)	diablo, IAP-binding mitochondrial protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Golgi Apparatus Nuclear Speck	Mitochondrion Mitochondrial Intermembrane Space Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex
	Molecular Function	Transcription Coactivator Activity	Protein Binding
	Biological Process	Transcription Initiation From RNA Polymerase II Promoter Notch Signaling Pathway Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Positive Regulation Of Apoptotic Process Neuron Apoptotic Process Intrinsic Apoptotic Signaling Pathway
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH NOTCH2 intracellular domain regulates transcription Notch-HLH transcription pathway Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH2 Generic Transcription Pathway Pre-NOTCH Transcription and Translation Signaling by NOTCH1 Pre-NOTCH Expression and Processing Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer	Release of apoptotic factors from the mitochondria Apoptotic factor-mediated response SMAC binds to IAPs Programmed Cell Death SMAC-mediated dissociation of IAP:caspase complexes SMAC-mediated apoptotic response Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS		Corneal astigmatism ( 23322567) Height ( 23456168) Response to treatment for acute lymphoblastic leukemia ( 19176441) Ulcerative colitis ( 23128233) Waist-to-hip circumference ratio (interaction) ( 23192594)
Protein-Protein Interactions		6 interactors: CREBBP DIABLO NOTCH1 NOTCH2 NOTCH3 NOTCH4	20 interactors: AREL1 ARL6IP1 ARNT BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 CASP9 EEF1A1 HTRA2 LTBR MAML2 NGFRAP1 NR4A1 SLC25A47 UBE2K UFM1 XIAP ZNF746
Entrez ID		84441	56616
HPRD ID		09608	05560
Ensembl ID			ENSG00000184047
Uniprot IDs		Q8IZL2	K7X1S0 Q502X2 Q9NR28
PDB IDs			1FEW 1G3F 1G73 1TW6 1XB0 1XB1 3D9U 3UIH 3UIJ
Enriched GO Terms of Interacting Partners?		Notch Receptor Processing Notch Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Negative Regulation Of Cell Differentiation Cell Fate Commitment Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription Of Notch Receptor Target Interleukin-4 Secretion Notch Signaling Involved In Heart Development Pulmonary Valve Morphogenesis Interleukin-4 Production Blood Vessel Development Vasculature Development Stem Cell Maintenance Cell Surface Receptor Signaling Pathway Embryonic Limb Morphogenesis Regulation Of Cell Differentiation Limb Morphogenesis Regulation Of Endothelial Cell Differentiation Limb Development Glomerulus Vasculature Development Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Stem Cell Development Cardiovascular System Development Cardiac Atrium Morphogenesis Inflammatory Response To Antigenic Stimulus Cytokine Secretion Heart Valve Morphogenesis Heart Valve Development Positive Regulation Of BMP Signaling Pathway Stem Cell Differentiation Transcription, DNA-templated Angiogenesis RNA Biosynthetic Process Anatomical Structure Morphogenesis Cell Fate Determination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Embryo Development Regulation Of DNA-templated Transcription In Response To Stress Cardiac Septum Morphogenesis Glomerulus Development Morphogenesis Of An Epithelial Sheet Blood Vessel Morphogenesis Signal Transduction Embryonic Digit Morphogenesis Pattern Specification Process Endothelial Cell Differentiation Protein Metabolic Process Neuron Fate Commitment	Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Regulation Of Proteolysis Regulation Of Cell Death Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Apoptotic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Proteolysis Protein Ubiquitination Negative Regulation Of Protein Processing Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Protein Metabolic Process Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Negative Regulation Of Cell Death Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Cell Death Apoptotic Signaling Pathway Regulation Of Metabolic Process Intrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of Necroptotic Process Positive Regulation Of Signal Transduction Negative Regulation Of Necrotic Cell Death Regulation Of RIG-I Signaling Pathway Regulation Of Necroptotic Process Regulation Of Signaling Intracellular Signal Transduction Protein Metabolic Process Regulation Of Neuron Death
Tagcloud ?		breakpoint call combines comparisons complexity computational discordance frame fusions inversion libraries mate nasopharyngeal npc pair ptk2 ptplb reads rearrangements reconstruction recurrently rsrc1 sanger smash somatic sp3 split structural yap1	angiogen angioprevention argeting attributes b2g2 ccm cdc2 cdc25c cdks conditioned esis gallate grape hallmarks hile howed hpmecs huvecs invasiveness ngioprevention normoxic o2 pc3 phytochemicals procyanidin smac tube vegfr2 warrants
Tagcloud (Difference) ?		breakpoint call combines comparisons complexity computational discordance frame fusions inversion libraries mate nasopharyngeal npc pair ptk2 ptplb reads rearrangements reconstruction recurrently rsrc1 sanger smash somatic sp3 split structural yap1	angiogen angioprevention argeting attributes b2g2 ccm cdc2 cdc25c cdks conditioned esis gallate grape hallmarks hile howed hpmecs huvecs invasiveness ngioprevention normoxic o2 pc3 phytochemicals procyanidin smac tube vegfr2 warrants
Tagcloud (Intersection) ?