MAML2 and NOTCH4

Number of citations of the paper that reports this interaction (PMID 12370315)
33

Data Source:
HPRD (in vivo)

		MAML2	NOTCH4
Gene Name		mastermind-like 2 (Drosophila)	notch 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Golgi Apparatus Nuclear Speck	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Surface
	Molecular Function	Transcription Coactivator Activity	Receptor Activity Calcium Ion Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Transcription Initiation From RNA Polymerase II Promoter Notch Signaling Pathway Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter	Patterning Of Blood Vessels Cell Fate Determination Morphogenesis Of A Branching Structure Endothelial Cell Morphogenesis Transcription Initiation From RNA Polymerase II Promoter Notch Signaling Pathway Notch Receptor Processing Positive Regulation Of Transcription Of Notch Receptor Target Embryo Development Gene Expression Hemopoiesis Cell Differentiation Mammary Gland Development Negative Regulation Of Cell Differentiation Negative Regulation Of Endothelial Cell Differentiation Positive Regulation Of Transcription, DNA-templated
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH NOTCH2 intracellular domain regulates transcription Notch-HLH transcription pathway Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH2 Generic Transcription Pathway Pre-NOTCH Transcription and Translation Signaling by NOTCH1 Pre-NOTCH Expression and Processing Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer	Notch-HLH transcription pathway Signaling by NOTCH4 Generic Transcription Pathway Pre-NOTCH Processing in Golgi Pre-NOTCH Transcription and Translation Signaling by NOTCH Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Expression and Processing
Drugs
Diseases
GWAS		Corneal astigmatism ( 23322567) Height ( 23456168) Response to treatment for acute lymphoblastic leukemia ( 19176441) Ulcerative colitis ( 23128233) Waist-to-hip circumference ratio (interaction) ( 23192594)	Age-related macular degeneration ( 22694956) Asthma ( 21804548) Circulating myeloperoxidase levels (serum) ( 23620142) Crohn's disease ( 23266558) Epstein-Barr virus immune response (EBNA-1) ( 23326239) HIV-1 control ( 20041166) Obesity-related traits ( 23251661) Prostate cancer ( 23535732) Schizophrenia ( 19571808 23894747) Systemic lupus erythematosus ( 21408207) Systemic sclerosis ( 21779181)
Protein-Protein Interactions		6 interactors: CREBBP DIABLO NOTCH1 NOTCH2 NOTCH3 NOTCH4	13 interactors: DLL4 EGFL7 FBXW7 MAML1 MAML2 MAML3 PSEN1 PSEN2 RBPJ SMAD2 SMAD3 SMAD4 TCEB1
Entrez ID		84441	4855
HPRD ID		09608	01290
Ensembl ID			ENSG00000204301
Uniprot IDs		Q8IZL2	Q99466
PDB IDs
Enriched GO Terms of Interacting Partners?		Notch Receptor Processing Notch Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Negative Regulation Of Cell Differentiation Cell Fate Commitment Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription Of Notch Receptor Target Interleukin-4 Secretion Notch Signaling Involved In Heart Development Pulmonary Valve Morphogenesis Interleukin-4 Production Blood Vessel Development Vasculature Development Stem Cell Maintenance Cell Surface Receptor Signaling Pathway Embryonic Limb Morphogenesis Regulation Of Cell Differentiation Limb Morphogenesis Regulation Of Endothelial Cell Differentiation Limb Development Glomerulus Vasculature Development Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Stem Cell Development Cardiovascular System Development Cardiac Atrium Morphogenesis Inflammatory Response To Antigenic Stimulus Cytokine Secretion Heart Valve Morphogenesis Heart Valve Development Positive Regulation Of BMP Signaling Pathway Stem Cell Differentiation Transcription, DNA-templated Angiogenesis RNA Biosynthetic Process Anatomical Structure Morphogenesis Cell Fate Determination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Embryo Development Regulation Of DNA-templated Transcription In Response To Stress Cardiac Septum Morphogenesis Glomerulus Development Morphogenesis Of An Epithelial Sheet Blood Vessel Morphogenesis Signal Transduction Embryonic Digit Morphogenesis Pattern Specification Process Endothelial Cell Differentiation Protein Metabolic Process Neuron Fate Commitment	Notch Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Cardiovascular System Development Tube Development Positive Regulation Of Metabolic Process Pattern Specification Process Regulation Of Transcription From RNA Polymerase II Promoter Heart Development Transcription From RNA Polymerase II Promoter Cell Fate Commitment SMAD Protein Complex Assembly Positive Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Surface Receptor Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Tube Morphogenesis Positive Regulation Of Cellular Metabolic Process Somitogenesis Regulation Of ERBB Signaling Pathway Heart Morphogenesis Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Somite Development Anterior/posterior Pattern Specification Notch Receptor Processing Regulation Of Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Epidermal Growth Factor-activated Receptor Activity Pericardium Development Segmentation Blood Vessel Lumenization Organ Morphogenesis Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Dorsal/ventral Pattern Formation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Epithelium Development Embryonic Morphogenesis Regulation Of RNA Metabolic Process Tissue Morphogenesis Anatomical Structure Morphogenesis Negative Regulation Of Cell Proliferation Tissue Development Cell Differentiation Embryo Development Positive Regulation Of BMP Signaling Pathway Epithelial Tube Morphogenesis
Tagcloud ?		breakpoint call combines comparisons complexity computational discordance frame fusions inversion libraries mate nasopharyngeal npc pair ptk2 ptplb reads rearrangements reconstruction recurrently rsrc1 sanger smash somatic sp3 split structural yap1	antileukemic antiproliferative apigenin baicalein cdc2 cdk4 cdk6 chrysin division dysregulated dysregulation flavonoids galangin genistein hl illustrated jurkat k562 luteolin naringenin nb4 potencies ppa proteomic scutellarin suppresses u937 ubiquitously xiap
Tagcloud (Difference) ?		breakpoint call combines comparisons complexity computational discordance frame fusions inversion libraries mate nasopharyngeal npc pair ptk2 ptplb reads rearrangements reconstruction recurrently rsrc1 sanger smash somatic sp3 split structural yap1	antileukemic antiproliferative apigenin baicalein cdc2 cdk4 cdk6 chrysin division dysregulated dysregulation flavonoids galangin genistein hl illustrated jurkat k562 luteolin naringenin nb4 potencies ppa proteomic scutellarin suppresses u937 ubiquitously xiap
Tagcloud (Intersection) ?