MAML2

Description		mastermind like transcriptional coactivator 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Speck
	Molecular Function	Transcription Coactivator Activity Protein Binding
	Biological Process	Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription NOTCH2 intracellular domain regulates transcription NOTCH2 intracellular domain regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Formation of paraxial mesoderm
Drugs
Diseases
GWAS		Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Corneal astigmatism ( 23322567) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 23456168) Hematocrit ( 32888494) Hemoglobin ( 32888494) Influenza A (H1N1) severity ( 26379185) Keratoconus ( 31855235) Methadone dose in opioid dependence ( 28115739) Non-glioblastoma glioma ( 28346443) Pelvic organ prolapse ( 26545240) Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) ( 25117820) Response to treatment for acute lymphoblastic leukemia ( 19176441) Ulcerative colitis ( 23128233 28067908) Waist-to-hip circumference ratio (alcohol intake interaction) ( 23192594)
Interacting Genes		8 interacting genes: CREBBP CTBP1 DIABLO NEDD4 NOTCH1 NOTCH2 NOTCH3 NOTCH4
Entrez ID		84441
HPRD ID		09608
Ensembl ID		ENSG00000184384
Uniprot IDs		Q8IZL2
PDB IDs
Enriched GO Terms of Interacting Partners?		Notch Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Transcription Coactivator Activity Negative Regulation Of RNA Biosynthetic Process Tube Morphogenesis Positive Regulation Of Smooth Muscle Cell Differentiation Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Tumor Cell Regulation Of Smooth Muscle Cell Differentiation Cell Surface Receptor Signaling Pathway Luteolysis Atrioventricular Node Development Glomerular Capillary Formation Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription Of Notch Receptor Target Signaling Receptor Activity Positive Regulation Of Muscle Cell Differentiation Negative Regulation Of Biosynthetic Process Negative Regulation Of Cell Adhesion Molecule Production Anatomical Structure Morphogenesis Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Macromolecule Metabolic Process Blood Vessel Morphogenesis Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Signal Transduction Endocardial Cushion Development Left/right Axis Specification Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription Enzyme Binding Pulmonary Valve Morphogenesis Positive Regulation Of Ras Protein Signal Transduction Positive Regulation Of RNA Metabolic Process Morphogenesis Of An Epithelial Sheet Neuron Projection Development Regulation Of Muscle Cell Differentiation Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Nephron Tubule Development Regulation Of RNA Biosynthetic Process Notch Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Renal Tubule Development Receptor Complex
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