ASPG and VPS25

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ASPG	VPS25
Description		asparaginase	vacuolar protein sorting 25 homolog
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	ESCRT II Complex Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Endosome Membrane Membrane Extracellular Exosome
	Molecular Function	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Asparaginase Activity Phosphatidylcholine Lysophospholipase Activity Protein Binding Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Hydrolase Activity	Structural Molecule Activity Protein Binding Protein Homodimerization Activity
	Biological Process	Amino Acid Metabolic Process Lipid Metabolic Process Aspartate Family Amino Acid Metabolic Process Lipid Catabolic Process	Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Transport Macroautophagy Multivesicular Body Assembly Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Multivesicular Body Sorting Pathway Membrane Fission
Pathways		Aspartate and asparagine metabolism	Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events
Drugs		Procaine
Diseases
GWAS		Body mass index ( 26426971) Plasma free amino acid levels (adjusted for one other PFAA) ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Plasma free asparagine levels ( 30659259) Refractive error ( 32231278) Schizophrenia ( 29483656) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite levels ( 33031748)
Interacting Genes		12 interacting genes: CEACAM6 CIMIP1 DMRT3 GSDMD MYOZ3 RTP5 SGK1 SHC3 TEKT3 TMEM115 USP2 VPS25	24 interacting genes: APIP ASPG B9D2 BEND5 BPIFA1 CHMP6 CRLF3 EIF4G3 GPR35 LTB4R2 PICK1 REL RHOXF2 SDCBP2 SEPTIN14 SNCA SNF8 SPG21 SPRY2 SYCE1 TADA2A TRIM27 UBC VPS36
Entrez ID		374569	84313
HPRD ID		19180	14396
Ensembl ID		ENSG00000166183	ENSG00000131475
Uniprot IDs		G3V1Y8 Q86U10	Q9BRG1
PDB IDs			2ZME 3CUQ 3HTU
Enriched GO Terms of Interacting Partners?			Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Organization ESCRT II Complex Multivesicular Body Assembly Late Endosome To Vacuole Transport Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Multivesicular Body Sorting Pathway Lipid Binding Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Endosome Organization Regulation Of Exosomal Secretion Negative Regulation Of Autophagy Endosomal Transport
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