ASPG and GSDMD

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ASPG	GSDMD
Description		asparaginase	gasdermin D
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane Mitochondrial Membrane Specific Granule Lumen Canonical Inflammasome Complex NLRP3 Inflammasome Complex Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Asparaginase Activity Phosphatidylcholine Lysophospholipase Activity Protein Binding Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Hydrolase Activity	Phosphatidylserine Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Lipid Binding Wide Pore Channel Activity Phosphatidylinositol-4-phosphate Binding Phosphatidic Acid Binding Cardiolipin Binding
	Biological Process	Amino Acid Metabolic Process Lipid Metabolic Process Aspartate Family Amino Acid Metabolic Process Lipid Catabolic Process	Plasma Membrane Repair Immune System Process Inflammatory Response Protein Secretion Programmed Cell Death Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Positive Regulation Of Interleukin-18 Production Interleukin-18-mediated Signaling Pathway Defense Response To Bacterium NLRP3 Inflammasome Complex Assembly Innate Immune Response Ceramide Biosynthetic Process Pore Complex Assembly Positive Regulation Of Inflammatory Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Protein Homooligomerization Protein Maturation Transmembrane Transport Pyroptotic Inflammatory Response Interleukin-1-mediated Signaling Pathway Pyroptotic Cell Death
Pathways		Aspartate and asparagine metabolism	Release of apoptotic factors from the mitochondria Interleukin-1 processing Pyroptosis Regulation of TLR by endogenous ligand Neutrophil degranulation Purinergic signaling in leishmaniasis infection CASP4-mediated substrate cleavage CASP5-mediated substrate cleavage
Drugs		Procaine
Diseases
GWAS		Body mass index ( 26426971) Plasma free amino acid levels (adjusted for one other PFAA) ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Plasma free asparagine levels ( 30659259) Refractive error ( 32231278) Schizophrenia ( 29483656) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite levels ( 33031748)	Alanine aminotransferase levels ( 33547301) Monocyte count ( 32888494) Schizophrenia ( 31268507)
Interacting Genes		12 interacting genes: CEACAM6 CIMIP1 DMRT3 GSDMD MYOZ3 RTP5 SGK1 SHC3 TEKT3 TMEM115 USP2 VPS25	9 interacting genes: ASPG CASP1 KCTD6 MEOX2 MFHAS1 PSMA1 ZBTB33 ZNF426 ZNF558
Entrez ID		374569	79792
HPRD ID		19180	11014
Ensembl ID		ENSG00000166183	ENSG00000104518
Uniprot IDs		G3V1Y8 Q86U10	P57764
PDB IDs			5NH1 5WQT 6AO4 6KN0 6N9O 6VFE 7Z1X
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?