DSP and COL17A1

Number of citations of the paper that reports this interaction (PMID 12482924)
29

Data Source:
HPRD (in vitro, two hybrid)

		DSP	COL17A1
Gene Name		desmoplakin	collagen, type XVII, alpha 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cornified Envelope Nucleus Mitochondrion Intermediate Filament Plasma Membrane Fascia Adherens Intercalated Disc Basolateral Plasma Membrane Desmosome Extracellular Vesicular Exosome	Extracellular Region Collagen Trimer Basement Membrane Endoplasmic Reticulum Lumen Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Hemidesmosome
	Molecular Function	Protein Kinase C Binding Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Protein Binding, Bridging Poly(A) RNA Binding Cell Adhesion Molecule Binding Scaffold Protein Binding	Protein Binding
	Biological Process	Desmosome Organization Ventricular Compact Myocardium Morphogenesis Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Epidermis Development Single Organismal Cell-cell Adhesion Peptide Cross-linking Keratinocyte Differentiation Adherens Junction Organization Wound Healing Intermediate Filament Organization Protein Localization To Adherens Junction Ventricular Cardiac Muscle Cell Action Potential Bundle Of His Cell To Purkinje Myocyte Communication Regulation Of Heart Rate By Cardiac Conduction	Cell-matrix Adhesion Epidermis Development Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Hemidesmosome Assembly Cell Junction Assembly
Pathways		Apoptotic cleavage of cell adhesion proteins Apoptotic cleavage of cellular proteins Programmed Cell Death Apoptotic execution phase	Cell junction organization Type I hemidesmosome assembly Collagen formation Collagen degradation Collagen biosynthesis and modifying enzymes Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures
Drugs
Diseases
GWAS		Interstitial lung disease ( 23583980)	Cardiac hypertrophy ( 21348951)
Protein-Protein Interactions		28 interactors: ARID3A CASP10 CASP2 CASP4 CASP6 CASP7 CASP9 CDH5 COL17A1 CSTA DES DSC1 EVPL IVL JUP KRT1 KRT5 KRT6A PECAM1 PKP1 PKP2 PKP3 PKP4 PRKACA PRKCE PSEN1 UCHL5 VIM	12 interactors: ACTN1 ACTN4 CLSTN1 CTNND1 DSP DST ITGA6 ITGB4 KRT18 LAD1 PLEC PPL
Entrez ID		1832	1308
HPRD ID		00513	00223
Ensembl ID		ENSG00000096696	ENSG00000065618
Uniprot IDs		D7RX09 P15924	Q9UMD9
PDB IDs		1LM5 1LM7 3R6N
Enriched GO Terms of Interacting Partners?		Desmosome Assembly Cell Junction Assembly Desmosome Organization Cell Adhesion Execution Phase Of Apoptosis Apoptotic Process Programmed Cell Death Cell Death Death Epithelium Development Tissue Development Developmental Process Anatomical Structure Development Cell-cell Junction Organization Skin Development Cell-cell Junction Assembly Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Intermediate Filament Organization Single Organismal Cell-cell Adhesion Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Proteolysis Organ Development Epidermis Development Multicellular Organismal Development System Development Intermediate Filament Cytoskeleton Organization Intermediate Filament Bundle Assembly Intermediate Filament-based Process Cardiac Conduction Peptide Cross-linking Cellular Component Assembly Bundle Of His Cell To Purkinje Myocyte Communication Regulation Of Heart Contraction Apoptotic Signaling Pathway Regulation Of Tight Junction Assembly Intrinsic Apoptotic Signaling Pathway Regulation Of Endopeptidase Activity Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Regulation Of Peptidase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Hemidesmosome Assembly Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Cell Cycle Process Signaling Neurotrophin Signaling Pathway Cell Communication By Electrical Coupling	Cell Junction Assembly Hemidesmosome Assembly Cell-substrate Junction Assembly Protein Localization To Cell Junction Protein Localization To Tight Junction Cell Adhesion Response To Wounding Extracellular Matrix Organization Extracellular Structure Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cell-cell Junction Organization Skin Development Cellular Component Assembly Nail Development Adherens Junction Organization Integrin-mediated Signaling Pathway Amelogenesis Actin Crosslink Formation Filopodium Assembly Cell-matrix Adhesion Cytoskeleton Organization Cell-substrate Adhesion Wound Healing Tight Junction Assembly Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Actin Filament Bundle Assembly Platelet Degranulation Golgi To Plasma Membrane CFTR Protein Transport Apical Junction Assembly Execution Phase Of Apoptosis Keratinocyte Differentiation Blood Coagulation Hemostasis Ventricular Compact Myocardium Morphogenesis Odontogenesis Of Dentin-containing Tooth Cell-cell Junction Assembly Positive Regulation Of Pinocytosis Single Organismal Cell-cell Adhesion Odontogenesis Positive Regulation Of Sodium:proton Antiporter Activity Protein Localization To Adherens Junction Epidermal Cell Differentiation Digestive Tract Development Regulation Of Body Fluid Levels Digestive System Development Response To Stress Regulation Of Sodium:proton Antiporter Activity Ectodermal Cell Differentiation Peroxisome Proliferator Activated Receptor Signaling Pathway
Tagcloud ?		aspirated cam5 cleaner dsus gcdfp ham56 hmb45 ipx k903 l26 mac387 mcea mcead14 nonneoplastic opd papanicolaou pcea plap processor scant scraped semiquantitatively slides thinprep tlp tlus tpp uchl unstained	aligning alopecia atrophic blistering bullosa codons corrective correlating dystrophy enamel epidermolysis exons faulty harbouring herlitz hypoplasia introns jeb junctional milder mucous nail nh nonsense pitting premtrna repaired vicinity xvii
Tagcloud (Difference) ?		aspirated cam5 cleaner dsus gcdfp ham56 hmb45 ipx k903 l26 mac387 mcea mcead14 nonneoplastic opd papanicolaou pcea plap processor scant scraped semiquantitatively slides thinprep tlp tlus tpp uchl unstained	aligning alopecia atrophic blistering bullosa codons corrective correlating dystrophy enamel epidermolysis exons faulty harbouring herlitz hypoplasia introns jeb junctional milder mucous nail nh nonsense pitting premtrna repaired vicinity xvii
Tagcloud (Intersection) ?