DSP and ARID3A

Number of citations of the paper that reports this interaction (PubMedID 9780002)
0

Data Source:
HPRD (in vivo)

		DSP	ARID3A
Description		desmoplakin	AT-rich interaction domain 3A
Image
GO Annotations	Cellular Component	Cornified Envelope Nucleus Cytoplasm Cytoskeleton Intermediate Filament Plasma Membrane Cell-cell Junction Adherens Junction Fascia Adherens Intercalated Disc Membrane Basolateral Plasma Membrane Desmosome Extracellular Exosome Anchoring Junction Ficolin-1-rich Granule Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Raft
	Molecular Function	RNA Binding Protein Kinase C Binding Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Scaffold Protein Binding	DNA Binding Chromatin Binding Transcription Coregulator Activity Protein Binding Identical Protein Binding
	Biological Process	Desmosome Organization Ventricular Compact Myocardium Morphogenesis Epidermis Development Peptide Cross-linking Keratinocyte Differentiation Adherens Junction Organization Wound Healing Skin Development Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Epithelial Cell-cell Adhesion Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential Protein Localization To Cell-cell Junction	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Apoptotic cleavage of cell adhesion proteins Neutrophil degranulation Keratinization Formation of the cornified envelope RND3 GTPase cycle RND1 GTPase cycle	TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Drugs		Zinc Artenimol Zinc acetate
Diseases		Striate palmoplantar keratoderma Skin fragility-woolly hair syndrome Arrhythmogenic right ventricular cardiomyopathy (ARVC) Naxos disease and Carvajal syndrome Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic
GWAS		Chronic obstructive pulmonary disease ( 28166215 30804561) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Idiopathic pulmonary fibrosis ( 29066090 31710517) Interstitial lung disease ( 23583980) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Numerical cognitive ability ( 31620175) PR interval ( 32439900) Response to fenofibrate (triglyceride levels) ( 27002377) Resting heart rate ( 27798624)	High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Primary biliary cholangitis ( 28425483) Systemic lupus erythematosus ( 28714469) Vertical cup-disc ratio ( 20548946)
Interacting Genes		36 interacting genes: ARID3A CASP10 CASP2 CASP4 CASP6 CASP7 CASP9 CDC42 CDH5 COL17A1 COPS6 DES DSC1 ENO3 EVPL H19 IVL JUP KRT1 KRT5 KRT6A MTDH PECAM1 PKP1 PKP2 PKP3 PKP4 PRKACA PRKCE PTEN RNF10 TTC3 UCHL5 USP7 VIM WEE2-AS1	21 interacting genes: ANKRD11 APP BTK DSP E2F1 E2F2 E2F4 KRT31 MAGEB2 MAGEB4 MORF4L1 MORF4L2 NOTCH2NLA PML REP15 SP100 TIMM8A TP53 TTC32 UBE2E3 XPA
Entrez ID		1832	1820
HPRD ID		00513	10343
Ensembl ID		ENSG00000096696	ENSG00000116017
Uniprot IDs		A0AAQ5BH43 B4DKX6 P15924	Q99856
PDB IDs		1LM5 1LM7 3R6N 5DZZ	2KK0 4LJX
Enriched GO Terms of Interacting Partners?		Cornified Envelope Desmosome Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Cysteine-type Endopeptidase Activity Cell-cell Junction Organization Desmosome Organization Cell Junction Assembly Intermediate Filament Organization Cysteine-type Peptidase Activity Cell-cell Junction Anchoring Junction Desmosome Assembly Cell Junction Organization Positive Regulation Of Neuron Apoptotic Process Cell-cell Junction Assembly Cytoplasm Peptidase Activity Keratinization Alpha-catenin Binding Adherens Junction Intermediate Filament Cytoskeleton Cadherin Binding Desmosome Maintenance Cytoskeleton Organization Cytosol Peptide Cross-linking Structural Constituent Of Skin Epidermis Supramolecular Fiber Organization Cell-cell Adhesion Cell Adhesion Epidermis Development Cellular Component Assembly Positive Regulation Of Signal Transduction Regulation Of Neuron Apoptotic Process Execution Phase Of Apoptosis Proteolysis Cellular Response To Staurosporine Protein Metabolic Process Protein Processing Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Protein Maturation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Periphery Response To Indole-3-methanol Cell Junction Structural Constituent Of Cytoskeleton Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication	Signal Transduction By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Lens Fiber Cell Apoptotic Process Rb-E2F Complex Positive Regulation Of RNA Metabolic Process DNA Damage Response DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of RNA Metabolic Process Signal Transduction In Response To DNA Damage Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Protein Dimerization Activity Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Cis-regulatory Region Sequence-specific DNA Binding Type II Interferon-mediated Signaling Pathway Regulation Of Gene Expression Regulation Of Apoptotic Process Regulation Of Cell Cycle Transcription Regulator Complex Regulation Of Fibroblast Proliferation Regulation Of Programmed Cell Death Regulation Of Macromolecule Biosynthetic Process Nucleus Negative Regulation Of Telomere Maintenance Via Telomerase PML Body Cellular Response To Stress Retinoic Acid Receptor Signaling Pathway Entrainment Of Circadian Clock By Photoperiod Regulation Of Cellular Response To Stress DNA-binding Transcription Activator Activity Positive Regulation Of Macromolecule Metabolic Process Molecular Function Activator Activity Maintenance Of Protein Location In Nucleus Positive Regulation Of Transcription By RNA Polymerase II NuA4 Histone Acetyltransferase Complex Apoptotic Process Response To Light Stimulus RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Photoperiodism Entrainment Of Circadian Clock Negative Regulation Of RNA Biosynthetic Process
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