DSP and DSC1

Number of citations of the paper that reports this interaction (PubMedID 9606214)
56

Data Source:
HPRD (in vitro)

		DSP	DSC1
Description		desmoplakin	desmocollin 1
Image
GO Annotations	Cellular Component	Cornified Envelope Nucleus Cytoplasm Cytoskeleton Intermediate Filament Plasma Membrane Cell-cell Junction Adherens Junction Fascia Adherens Intercalated Disc Membrane Basolateral Plasma Membrane Desmosome Extracellular Exosome Anchoring Junction Ficolin-1-rich Granule Membrane	Cornified Envelope Plasma Membrane Gap Junction Membrane Cell Junction Desmosome Extracellular Exosome Anchoring Junction Ficolin-1-rich Granule Membrane
	Molecular Function	RNA Binding Protein Kinase C Binding Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Scaffold Protein Binding	Calcium Ion Binding Protein Binding Metal Ion Binding
	Biological Process	Desmosome Organization Ventricular Compact Myocardium Morphogenesis Epidermis Development Peptide Cross-linking Keratinocyte Differentiation Adherens Junction Organization Wound Healing Skin Development Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Epithelial Cell-cell Adhesion Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential Protein Localization To Cell-cell Junction	Desmosome Maintenance Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Hair Follicle Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Establishment Of Skin Barrier Cell-cell Adhesion
Pathways		Apoptotic cleavage of cell adhesion proteins Neutrophil degranulation Keratinization Formation of the cornified envelope RND3 GTPase cycle RND1 GTPase cycle	Neutrophil degranulation Keratinization Formation of the cornified envelope
Drugs		Zinc Artenimol Zinc acetate
Diseases		Striate palmoplantar keratoderma Skin fragility-woolly hair syndrome Arrhythmogenic right ventricular cardiomyopathy (ARVC) Naxos disease and Carvajal syndrome Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic
GWAS		Chronic obstructive pulmonary disease ( 28166215 30804561) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Idiopathic pulmonary fibrosis ( 29066090 31710517) Interstitial lung disease ( 23583980) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Numerical cognitive ability ( 31620175) PR interval ( 32439900) Response to fenofibrate (triglyceride levels) ( 27002377) Resting heart rate ( 27798624)	Multiple sclerosis ( 23412934)
Interacting Genes		36 interacting genes: ARID3A CASP10 CASP2 CASP4 CASP6 CASP7 CASP9 CDC42 CDH5 COL17A1 COPS6 DES DSC1 ENO3 EVPL H19 IVL JUP KRT1 KRT5 KRT6A MTDH PECAM1 PKP1 PKP2 PKP3 PKP4 PRKACA PRKCE PTEN RNF10 TTC3 UCHL5 USP7 VIM WEE2-AS1	10 interacting genes: DSG1 DSG2 DSP JUP NEIL3 PKP1 PKP2 PKP3 UCHL5 WEE2-AS1
Entrez ID		1832	1823
HPRD ID		00513	00511
Ensembl ID		ENSG00000096696	ENSG00000134765
Uniprot IDs		A0AAQ5BH43 B4DKX6 P15924	Q08554 Q9HB00
PDB IDs		1LM5 1LM7 3R6N 5DZZ	5IRY
Enriched GO Terms of Interacting Partners?		Cornified Envelope Desmosome Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Cysteine-type Endopeptidase Activity Cell-cell Junction Organization Desmosome Organization Cell Junction Assembly Intermediate Filament Organization Cysteine-type Peptidase Activity Cell-cell Junction Anchoring Junction Desmosome Assembly Cell Junction Organization Positive Regulation Of Neuron Apoptotic Process Cell-cell Junction Assembly Cytoplasm Peptidase Activity Keratinization Alpha-catenin Binding Adherens Junction Intermediate Filament Cytoskeleton Cadherin Binding Desmosome Maintenance Cytoskeleton Organization Cytosol Peptide Cross-linking Structural Constituent Of Skin Epidermis Supramolecular Fiber Organization Cell-cell Adhesion Cell Adhesion Epidermis Development Cellular Component Assembly Positive Regulation Of Signal Transduction Regulation Of Neuron Apoptotic Process Execution Phase Of Apoptosis Proteolysis Cellular Response To Staurosporine Protein Metabolic Process Protein Processing Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Protein Maturation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Periphery Response To Indole-3-methanol Cell Junction Structural Constituent Of Cytoskeleton Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication	Desmosome Desmosome Organization Cornified Envelope Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Cell-cell Junction Organization Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Desmosome Assembly Regulation Of Ventricular Cardiac Muscle Cell Action Potential Anchoring Junction Cell-cell Junction Cell Junction Organization Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Contraction Cell-cell Adhesion Heterotypic Cell-cell Adhesion Cell-cell Junction Assembly Regulation Of Heart Rate By Cardiac Conduction Intercalated Disc Cardiac Conduction Alpha-catenin Binding Regulation Of Action Potential Homotypic Cell-cell Adhesion Adherens Junction Cell Adhesion Regulation Of Cardiac Muscle Contraction Epithelial Cell-cell Adhesion Cell Junction Assembly Regulation Of Striated Muscle Contraction Regulation Of Heart Rate Intermediate Filament Regulation Of Muscle Contraction Regulation Of Heart Contraction Ficolin-1-rich Granule Membrane Intermediate Filament Binding Regulation Of Muscle System Process Intermediate Filament Bundle Assembly Intermediate Filament Organization Regulation Of Blood Circulation Cell Adhesion Molecule Binding Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cadherin Binding Regulation Of Cell Adhesion Regulation Of Actin Filament-based Process Regulation Of Membrane Potential Positive Regulation Of Protein Localization Positive Regulation Of Cell Adhesion Maternal Process Involved In Female Pregnancy Protein Localization To Plasma Membrane
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