GINS4 and POLE

Number of citations of the paper that reports this interaction (PMID 21705323)
14

Data Source:
BioGRID (pull down)

		GINS4	POLE
Gene Name		GINS complex subunit 4 (Sld5 homolog)	polymerase (DNA directed), epsilon, catalytic subunit
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm	Nucleus Nucleoplasm Cytoplasm Plasma Membrane Epsilon DNA Polymerase Complex
	Molecular Function	Protein Binding	Nucleotide Binding DNA Binding Chromatin Binding DNA-directed DNA Polymerase Activity Zinc Ion Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Mitotic Cell Cycle Inner Cell Mass Cell Proliferation DNA Strand Elongation Involved In DNA Replication	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Synthesis Involved In DNA Repair In Utero Embryonic Development DNA Replication DNA Replication Initiation DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair, Gap-filling Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication
Pathways		Synthesis of DNA S Phase DNA strand elongation Cell Cycle, Mitotic Unwinding of DNA	Nucleotide Excision Repair Synthesis of DNA Chromosome Maintenance Telomere C-strand synthesis initiation Gap-filling DNA repair synthesis and ligation in TC-NER Activation of the pre-replicative complex DNA Replication Pre-Initiation Repair synthesis for gap-filling by DNA polymerase in TC-NER Extension of Telomeres M/G1 Transition Activation of the pre-replicative complex S Phase Telomere C-strand (Lagging Strand) Synthesis Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER DNA replication initiation Global Genomic NER (GG-NER) Telomere Maintenance G1/S Transition Transcription-coupled NER (TC-NER) Mitotic G1-G1/S phases
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: GINS1 GINS2 GINS3 POLA1 POLD1 POLE	12 interactors: GINS4 MDM2 PCNA POLA1 POLD4 POLE2 POLE3 POLE4 RAD17 STK19 TOPBP1 XRCC5
Entrez ID		84296	5426
HPRD ID		11583	07177
Ensembl ID		ENSG00000147536	ENSG00000177084
Uniprot IDs		Q9BRT9	F5H1D6 Q07864
PDB IDs		2E9X 2EHO 2Q9Q
Enriched GO Terms of Interacting Partners?		DNA Replication DNA-dependent DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation DNA Metabolic Process Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination Telomere Maintenance Via Telomere Lengthening Mitotic Cell Cycle Base-excision Repair, Gap-filling Telomere Maintenance DNA Biosynthetic Process Cell Cycle DNA Synthesis Involved In DNA Repair Nucleotide-excision Repair, DNA Gap Filling Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process DNA Recombination DNA Replication Initiation Transcription-coupled Nucleotide-excision Repair Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Base-excision Repair Nitrogen Compound Metabolic Process Nucleotide-excision Repair DNA Replication Proofreading DNA Repair Cellular Homeostasis Leading Strand Elongation G1/S Transition Of Mitotic Cell Cycle Cellular Response To DNA Damage Stimulus Lagging Strand Elongation Chromosome Organization Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Replication, Synthesis Of RNA Primer Homeostatic Process Fatty Acid Homeostasis Cellular Response To Stress Double-strand Break Repair Via Nonhomologous End Joining Inner Cell Mass Cell Proliferation Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Metabolic Process In Utero Embryonic Development	DNA Metabolic Process DNA Biosynthetic Process DNA Replication Telomere Maintenance Via Semi-conservative Replication Telomere Maintenance Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Strand Elongation Involved In DNA Replication Cellular Response To DNA Damage Stimulus DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening DNA-dependent DNA Replication DNA Repair Mitotic Cell Cycle Nucleotide-excision Repair, DNA Gap Filling DNA Recombination Cellular Response To Stress Chromosome Organization Leading Strand Elongation Transcription-coupled Nucleotide-excision Repair Cell Cycle Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cell Cycle Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Translesion Synthesis Mitotic Cell Cycle Process Nucleotide-excision Repair Nitrogen Compound Metabolic Process Cellular Metabolic Process Postreplication Repair Double-strand Break Repair Via Nonhomologous End Joining Response To Stress Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle G1/S Transition Of Mitotic Cell Cycle Biosynthetic Process DNA Replication Initiation Histone H3 Acetylation Peptidyl-lysine Modification Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cellular Homeostasis Organelle Organization Cell Proliferation Homeostatic Process Mismatch Repair
Tagcloud ?		annotations birc5 cdca2 cdh3 cited1 dhfr esco2 gins1 hells mc1r melana melanocyte melanocytes melk msg ncapg ncapg2 ncaph nusap1 oca2 pax3 pbk rad54l recapitulate revolutionized segregating subclasses tyms unsupervised	absolute bfgf bmp cdnas disruption dorsal embryo embryogenesis explants fate globin helix hematopoietic inductive lineages marginal mesoderm myod organogenesis participates patterning progenitors requirement scl specify specifying ventral xenopus zone
Tagcloud (Difference) ?		annotations birc5 cdca2 cdh3 cited1 dhfr esco2 gins1 hells mc1r melana melanocyte melanocytes melk msg ncapg ncapg2 ncaph nusap1 oca2 pax3 pbk rad54l recapitulate revolutionized segregating subclasses tyms unsupervised	absolute bfgf bmp cdnas disruption dorsal embryo embryogenesis explants fate globin helix hematopoietic inductive lineages marginal mesoderm myod organogenesis participates patterning progenitors requirement scl specify specifying ventral xenopus zone
Tagcloud (Intersection) ?