POLE and POLD4

Number of citations of the paper that reports this interaction (PubMedID 21705323)
58

Data Source:
BioGRID (pull down)

		POLE	POLD4
Description		DNA polymerase epsilon, catalytic subunit	DNA polymerase delta 4, accessory subunit
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Plasma Membrane Epsilon DNA Polymerase Complex	Nucleus Nucleoplasm Delta DNA Polymerase Complex
	Molecular Function	Nucleotide Binding Nucleic Acid Binding DNA Binding Chromatin Binding DNA-directed DNA Polymerase Activity Protein Binding Zinc Ion Binding Single-stranded DNA 3'-5' DNA Exonuclease Activity Transferase Activity Nucleotidyltransferase Activity Hydrolase Activity DNA Polymerase Activity Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding	DNA-directed DNA Polymerase Activity Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Synthesis Involved In DNA Repair DNA Replication DNA-templated DNA Replication Leading Strand Elongation DNA Repair Base-excision Repair, Gap-filling Nucleotide-excision Repair, DNA Gap Filling DNA Damage Response DNA Replication Proofreading Embryonic Organ Development DNA Biosynthetic Process	DNA Synthesis Involved In DNA Repair Positive Regulation Of Endothelial Cell Proliferation DNA Replication DNA-templated DNA Replication DNA Repair DNA Damage Response
Pathways		Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex	Recognition of DNA damage by PCNA-containing replication complex Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Removal of the Flap Intermediate from the C-strand Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs		Cladribine
Diseases
GWAS		Body mass index ( 26426971) Metabolite levels ( 23823483) Urate levels in overweight individuals ( 25811787)	Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634)
Interacting Genes		13 interacting genes: ABHD16A CFTR CLSPN GINS4 MDM2 PCNA POLA1 POLD4 POLE4 RAD17 TOPBP1 WHR1 XRCC5	9 interacting genes: DTL PCNA POLD1 POLD2 POLD3 POLE RNF8 SEC23IP WRNIP1
Entrez ID		5426	57804
HPRD ID		07177	17873
Ensembl ID		ENSG00000177084	ENSG00000175482
Uniprot IDs		Q07864	Q6NSD7 Q9HCU8
PDB IDs		5VBN 7PFO 7PLO 9B8S 9B8T 9F6D 9F6E 9F6F 9F6I 9F6J 9F6K 9F6L	6HVO 6S1M 6S1N 6S1O 6TNY 6TNZ 9EKB
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process DNA Repair Response To Stress DNA Damage Response Cellular Response To Stress DNA Biosynthetic Process Mitotic DNA Replication Checkpoint Signaling DNA-templated DNA Replication DNA Replication DNA Replication Checkpoint Signaling DNA-directed DNA Polymerase Activity Nucleic Acid Metabolic Process Leading Strand Elongation DNA Synthesis Involved In DNA Repair Macromolecule Metabolic Process Signal Transduction In Response To DNA Damage Male Germ Cell Nucleus Mitotic G2/M Transition Checkpoint Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Mitotic DNA Damage Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Cell Cycle G2/M Phase Transition DNA Strand Elongation Involved In DNA Replication Double-strand Break Repair Protein-containing Complex Chromatin-protein Adaptor Activity DNA Damage Checkpoint Signaling Response To Lipid DNA Strand Elongation Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Localization To Chromosome Regulation Of Cell Cycle G2/M Phase Transition Nucleoplasm Protein Localization To Site Of Double-strand Break DNA Replication Initiation Cellular Response To Gamma Radiation Recycling Endosome Regulation Of Mitotic Cell Cycle Phase Transition Recombinational Repair Response To Hormone Response To Ionizing Radiation Chromosome Organization Protein-containing Complex Binding Protein Localization To Organelle Mitotic G2 DNA Damage Checkpoint Signaling Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Sphingolipid Mediated Signaling Pathway High-density Lipoprotein Particle Receptor Activity	DNA Synthesis Involved In DNA Repair DNA Biosynthetic Process DNA Replication Translesion Synthesis Postreplication Repair DNA Repair DNA-templated DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Metabolic Process DNA Strand Elongation DNA Damage Response Delta DNA Polymerase Complex Nucleotide-excision Repair, DNA Gap Filling Nucleobase-containing Compound Biosynthetic Process Base-excision Repair, Gap-filling Cellular Response To Stress DNA-directed DNA Polymerase Activity Nucleic Acid Metabolic Process DNA Replication Proofreading Macromolecule Biosynthetic Process Chromosome, Telomeric Region Leading Strand Elongation Zeta DNA Polymerase Complex Nucleobase-containing Compound Metabolic Process Response To Stress Error-prone Translesion Synthesis DNA Polymerase Activity Response To Radiation Response To UV Chromatin Binding Mismatch Repair 4 Iron, 4 Sulfur Cluster Binding Macromolecule Metabolic Process PCNA Complex Damaged DNA Binding Replisome Response To Light Stimulus Iron-sulfur Cluster Binding Nucleoplasm Cellular Response To UV PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Nucleotidyltransferase Activity Cellular Response To Light Stimulus Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Regulation Of DNA Replication DNA Synthesis Involved In UV-damage Excision Repair Regulation Of DNA Metabolic Process
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