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POLE and POLD4
Number of citations of the paper that reports this interaction (PMID
21705323
)
14
Data Source:
BioGRID
(pull down)
POLE
POLD4
Gene Name
polymerase (DNA directed), epsilon, catalytic subunit
polymerase (DNA-directed), delta 4, accessory subunit
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Plasma Membrane
Epsilon DNA Polymerase Complex
Nucleus
Nucleoplasm
Molecular Function
Nucleotide Binding
DNA Binding
Chromatin Binding
DNA-directed DNA Polymerase Activity
Zinc Ion Binding
4 Iron, 4 Sulfur Cluster Binding
DNA-directed DNA Polymerase Activity
Protein Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Telomere Maintenance Via Recombination
Telomere Maintenance
DNA Synthesis Involved In DNA Repair
In Utero Embryonic Development
DNA Replication
DNA Replication Initiation
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Base-excision Repair, Gap-filling
Nucleotide-excision Repair
Nucleotide-excision Repair, DNA Gap Filling
Telomere Maintenance Via Semi-conservative Replication
Mitotic Cell Cycle
Telomere Maintenance Via Recombination
Telomere Maintenance
DNA Replication
DNA Strand Elongation Involved In DNA Replication
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Base-excision Repair
Nucleotide-excision Repair
Nucleotide-excision Repair, DNA Gap Filling
Mismatch Repair
Telomere Maintenance Via Semi-conservative Replication
DNA Biosynthetic Process
Pathways
Nucleotide Excision Repair
Synthesis of DNA
Chromosome Maintenance
Telomere C-strand synthesis initiation
Gap-filling DNA repair synthesis and ligation in TC-NER
Activation of the pre-replicative complex
DNA Replication Pre-Initiation
Repair synthesis for gap-filling by DNA polymerase in TC-NER
Extension of Telomeres
M/G1 Transition
Activation of the pre-replicative complex
S Phase
Telomere C-strand (Lagging Strand) Synthesis
Repair synthesis of patch ~27-30 bases long by DNA polymerase
Cell Cycle, Mitotic
Gap-filling DNA repair synthesis and ligation in GG-NER
DNA replication initiation
Global Genomic NER (GG-NER)
Telomere Maintenance
G1/S Transition
Transcription-coupled NER (TC-NER)
Mitotic G1-G1/S phases
Nucleotide Excision Repair
Gap-filling DNA repair synthesis and ligation in TC-NER
Extension of Telomeres
Repair synthesis for gap-filling by DNA polymerase in TC-NER
Leading Strand Synthesis
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
DNA strand elongation
Mismatch Repair
Polymerase switching
Telomere Maintenance
Removal of DNA patch containing abasic residue
Resolution of Abasic Sites (AP sites)
Removal of the Flap Intermediate from the C-strand
Base Excision Repair
Polymerase switching on the C-strand of the telomere
Synthesis of DNA
Chromosome Maintenance
Lagging Strand Synthesis
Processive synthesis on the C-strand of the telomere
Processive synthesis on the lagging strand
S Phase
Telomere C-strand (Lagging Strand) Synthesis
Repair synthesis of patch ~27-30 bases long by DNA polymerase
Cell Cycle, Mitotic
Gap-filling DNA repair synthesis and ligation in GG-NER
Removal of the Flap Intermediate
Global Genomic NER (GG-NER)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway
Transcription-coupled NER (TC-NER)
Drugs
Diseases
GWAS
Protein-Protein Interactions
12 interactors:
GINS4
MDM2
PCNA
POLA1
POLD4
POLE2
POLE3
POLE4
RAD17
STK19
TOPBP1
XRCC5
7 interactors:
PCNA
POLD1
POLD2
POLD3
POLE
SEC23IP
WRNIP1
Entrez ID
5426
57804
HPRD ID
07177
17873
Ensembl ID
ENSG00000177084
Uniprot IDs
F5H1D6
Q07864
Q6NSD7
Q9HCU8
PDB IDs
Enriched GO Terms of Interacting Partners
?
DNA Metabolic Process
DNA Biosynthetic Process
DNA Replication
Telomere Maintenance Via Semi-conservative Replication
Telomere Maintenance
Nuclear DNA Replication
Telomere Maintenance Via Recombination
Mitotic Recombination
DNA Strand Elongation Involved In DNA Replication
Cellular Response To DNA Damage Stimulus
DNA Strand Elongation
Telomere Maintenance Via Telomere Lengthening
DNA-dependent DNA Replication
DNA Repair
Mitotic Cell Cycle
Nucleotide-excision Repair, DNA Gap Filling
DNA Recombination
Cellular Response To Stress
Chromosome Organization
Leading Strand Elongation
Transcription-coupled Nucleotide-excision Repair
Cell Cycle
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cell Cycle Process
Cellular Aromatic Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Cellular Nitrogen Compound Metabolic Process
Translesion Synthesis
Mitotic Cell Cycle Process
Nucleotide-excision Repair
Nitrogen Compound Metabolic Process
Cellular Metabolic Process
Postreplication Repair
Double-strand Break Repair Via Nonhomologous End Joining
Response To Stress
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
G1/S Transition Of Mitotic Cell Cycle
Biosynthetic Process
DNA Replication Initiation
Histone H3 Acetylation
Peptidyl-lysine Modification
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Cellular Homeostasis
Organelle Organization
Cell Proliferation
Homeostatic Process
Mismatch Repair
Nucleotide-excision Repair, DNA Gap Filling
Telomere Maintenance Via Semi-conservative Replication
Nuclear DNA Replication
Telomere Maintenance Via Recombination
Mitotic Recombination
DNA Biosynthetic Process
Telomere Maintenance Via Telomere Lengthening
Transcription-coupled Nucleotide-excision Repair
Base-excision Repair
DNA Synthesis Involved In DNA Repair
Telomere Maintenance
DNA Replication
Nucleotide-excision Repair
DNA-dependent DNA Replication
DNA Strand Elongation Involved In DNA Replication
DNA Strand Elongation
Mismatch Repair
DNA Repair
DNA Recombination
Cellular Response To DNA Damage Stimulus
DNA Metabolic Process
Cellular Homeostasis
Cellular Response To Stress
Mitotic Cell Cycle
Base-excision Repair, Gap-filling
Chromosome Organization
Cell Cycle Process
Cell Cycle
Homeostatic Process
Organelle Organization
Response To Stress
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Positive Regulation Of Deoxyribonuclease Activity
DNA Replication Proofreading
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Biosynthetic Process
Cellular Nitrogen Compound Metabolic Process
Leading Strand Elongation
Regulation Of DNA Replication
Nitrogen Compound Metabolic Process
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle Phase Transition
Regulation Of DNA-dependent DNA Replication Initiation
Cell Cycle Phase Transition
Cellular Response To Stimulus
Translesion Synthesis
Fatty Acid Homeostasis
Tagcloud
?
absolute
bfgf
bmp
cdnas
disruption
dorsal
embryo
embryogenesis
explants
fate
globin
helix
hematopoietic
inductive
lineages
marginal
mesoderm
myod
organogenesis
participates
patterning
progenitors
requirement
scl
specify
specifying
ventral
xenopus
zone
Tagcloud (Difference)
?
absolute
bfgf
bmp
cdnas
disruption
dorsal
embryo
embryogenesis
explants
fate
globin
helix
hematopoietic
inductive
lineages
marginal
mesoderm
myod
organogenesis
participates
patterning
progenitors
requirement
scl
specify
specifying
ventral
xenopus
zone
Tagcloud (Intersection)
?